ArticlePloS one2015
The spacing principle for unlearning abnormal neuronal synchrony.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Mean-Field Approximations With Adaptive Coupling for Networks With Spike-Timing-Dependent Plasticity.Neural computation · 2023Article
- Dynamics of phase oscillator networks with synaptic weight and structural plasticity.Scientific reports · 2022Article
- Shuffling Improves the Acute and Carryover Effect of Subthalamic Coordinated Reset Deep Brain Stimulation.Frontiers in neurology · 2022Article
- Collective Activity Bursting in a Population of Excitable Units Adaptively Coupled to a Pool of Resources.Frontiers in network physiology · 2022Article
- Long-Term Desynchronization by Coordinated Reset Stimulation in a Neural Network Model With Synaptic and Structural Plasticity.Frontiers in physiology · 2021Article
- Treatment Tone Spacing and Acute Effects of Acoustic Coordinated Reset Stimulation in Tinnitus Patients.Frontiers in network physiology · 2021Article
- Clinical Efficacy and Dosing of Vibrotactile Coordinated Reset Stimulation in Motor and Non-motor Symptoms of Parkinson's Disease: A Study Protocol.Frontiers in neurology · 2021Article
- Acoustic coordinated reset therapy for tinnitus with perceptually relevant frequency spacing and levels.Scientific reports · 2019Article
- Complex partial synchronization patterns in networks of delay-coupled neurons.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2019Article
- Frequency cluster formation and slow oscillations in neural populations with plasticity.PloS one · 2019Article
- How stimulation frequency and intensity impact on the long-lasting effects of coordinated reset stimulation.PLoS computational biology · 2018Article
- Making Memories: Why Time Matters.Frontiers in human neuroscience · 2018Review
- Short-Term Dosage Regimen for Stimulation-Induced Long-Lasting Desynchronization.Frontiers in physiology · 2018Article
- Periodic flashing coordinated reset stimulation paradigm reduces sensitivity to ON and OFF period durations.PloS one · 2018Article
- Closed-loop deep brain stimulation by pulsatile delayed feedback with increased gap between pulse phases.Scientific reports · 2017Article
- EEG-Neurofeedback as a Tool to Modulate Cognition and Behavior: A Review Tutorial.Frontiers in human neuroscience · 2017Article
- Article
- Anti-kindling Induced by Two-Stage Coordinated Reset Stimulation with Weak Onset Intensity.Frontiers in computational neuroscience · 2016Article
- Maladaptive neural synchrony in tinnitus: origin and restoration.Frontiers in neurology · 2015Review
- Augmented brain function by coordinated reset stimulation with slowly varying sequences.Frontiers in systems neuroscience · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Desynchronizing stimulation techniques were developed to specifically counteract abnormal neuronal synchronization relevant to several neurological and psychiatric disorders. The goal of our approach is to achieve an anti-kindling, where the affected neural networks unlearn abnormal synaptic connectivity and, hence, abnormal neuronal synchrony, by means of desynchronizing stimulation, in particular, Coordinated Reset (CR) stimulation. As known from neuroscience, psychology and education, learning effects can be enhanced by means of the spacing principle, i.e. by delivering repeated stimuli spaced by pauses as opposed to delivering a massed stimulus (in a single long stimulation session). To illustrate that the spacing principle may boost the anti-kindling effect of CR neuromodulation, in this computational study we carry this approach to extremes. To this end, we deliver spaced CR neuromodulation at particularly weak intensities which render permanently delivered CR neuromodulation ineffective. Intriguingly, spaced CR neuromodulation at these particularly weak intensities effectively induces an anti-kindling. In fact, the spacing principle enables the neuronal population to successively hop from one attractor to another one, finally approaching attractors characterized by down-regulated synaptic connectivity and synchrony. Our computational results might open up novel opportunities to effectively induce sustained desynchronization at particularly weak stimulation intensities, thereby avoiding side effects, e.g., in the case of deep brain stimulation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.