ArticlePsychiatric genetics2015
Investigating the role of early childhood abuse and HPA axis genes in suicide attempters with bipolar disorder.
Article in Psychiatric genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Pooled it
- Interactions Between Variation in Candidate Genes and Environmental Factors in the Etiology of Schizophrenia and Bipolar Disorder: a Systematic Review.Molecular neurobiology · 2018Pooled it
- The Interaction BetweenBrain sciences · 2025Article
- Review: Suicide and its relationship to aggression and impulsivity.Cognitive, affective & behavioral neuroscience · 2025Review
- The Influence of Genetic Polymorphisms and Psychosocial Determinants on Suicidal Behaviors: A Case-Control Study ofInternational journal of molecular sciences · 2025Article
- Article
- Gene-Environment Interactions in Psychiatry: Recent Evidence and Clinical Implications.Current psychiatry reports · 2019Review
- Effect of CRHR1 and CRHR2 gene polymorphisms and childhood trauma in suicide attempt.Journal of neural transmission (Vienna, Austria : 1996) · 2019Article
- Influence of CRHR1 Polymorphisms and Childhood Abuse on Suicide Attempts in Affective Disorders: A GxE Approach.Frontiers in psychiatry · 2018Article
- Assessment of Whole-Exome Sequence Data in Attempted Suicide within a Bipolar Disorder Cohort.Molecular neuropsychiatry · 2017Article
- Don't stress about CRF: assessing the translational failures of CRFPsychopharmacology · 2017Review
- Bipolarity and suicidal ideation in children and adolescents: a systematic review with meta-analysis.Annals of general psychiatry · 2017Review
- Article
- Investigating the Relationship Between DNA Methylation, Genetic Variation, and Suicide Attempt in Bipolar Disorder.Archives of suicide research : official journal of the International Academy for Suicide ResearchArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveGenes and the environment both play a major role in the risk for attempted suicide, and environments harboring stressors, such as early childhood abuse, have been linked to suicidal behavior. Such environments also disrupt the hypothalamic-pituitary-adrenal (HPA) axis pathway, which has been hypothesized to play a role in suicidal behavior. We investigated whether the risk for attempted suicide was attributable in part to the interaction between childhood physical and/or sexual abuse and genetic variation in 19 genes (±5 kb) integral to the HPA axis pathway. MATERIALS AND
methodsUsing the Genetic Association Information Network Bipolar Disorder and Translational Genomics Research Institute cohorts, we implemented PLINK's logistic regression-based 'interaction' approach to search for evidence of an interaction between 235 genotyped HPA axis single-nucleotide polymorphisms and early childhood abuse. Our study included 631 bipolar disorder suicide attempters and 657 bipolar disorder nonattempters with information on abuse.
resultsAfter correction for multiple testing, no significant interaction between the 235 HPA axis single-nucleotide polymorphisms and early childhood abuse was found. In our study, the strongest interaction was found with rs2664008 in the corticotropin-releasing hormone receptor 1 (CRHR1) gene, with a nominal interaction P-value of 1.22×10 and an interaction odds ratio of 0.47.
conclusionOur findings suggest that further work and larger sample sizes are required to elucidate the link between early childhood abuse and the HPA axis in suicidal behavior.
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