Evidence map›Paper›PMID 25714186›Full record

ArticleBJU international2016

Relationship between illness uncertainty, anxiety, fear of progression and quality of life in men with favourable-risk prostate cancer undergoing active surveillance.

Patricia A Parker, John W Davis, David M Latini, George Baum, Xuemei Wang, John F Ward, Deborah Kuban, Steven J Frank, Andrew K Lee, Christopher J Logothetis and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BJU international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Correlates of illness uncertainty in cancer survivors and family caregivers: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Pooled it
  2. Fear of cancer recurrence and PSA anxiety in patients with prostate cancer: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Patricia A ParkerThe University of Texas MD Anderson Cancer Center, Houston, TX, USA.
John W DavisThe University of Texas MD Anderson Cancer Center, Houston, TX, USA.
David M LatiniBaylor College of Medicine and Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX, USA.
George BaumThe University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Xuemei WangThe University of Texas MD Anderson Cancer Center, Houston, TX, USA.
John F WardThe University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Deborah KubanThe University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Steven J FrankThe University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Andrew K LeeThe University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Christopher J LogothetisThe University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Jeri KimThe University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8M
NCI NIH HHS P30 CA016672NCI NIH HHS P30CA 16672
6 · The paper itself

Abstract

objectivesTo evaluate prospectively the associations between illness uncertainty, anxiety, fear of progression and general and disease-specific quality of life (QoL) in men with favourable-risk prostate cancer undergoing active surveillance (AS). PATIENTS AND

methodsAfter meeting stringent enrollment criteria for an AS cohort study at a single tertiary care cancer centre, 180 men with favourable-risk prostate cancer completed questionnaires at the time of enrollment and every 6 months for up to 30 months. Questionnaires assessed illness uncertainty, anxiety, prostate-specific QoL (using the Expanded Prostate Cancer Index Composite [EPIC] scale) and general QoL (using the 12-time short-form health survey [SF-12]) and fear of progression. We used linear mixed-model analyses and multilevel mediation analyses.

resultsSexual scores on the EPIC scale significantly declined over time (P < 0.05). Illness uncertainty was a significant predictor of all EPIC summary scores, SF-12 physical component summary (PCS) scores, mental component summary (MCS) scores and fear of progression scores (all P < 0.05), after controlling for demographic and clinicopathological factors. Anxiety predicted all EPIC summary, MCS and fear of progression scores (all P < 0.05) but not PCS scores (P = 0.08). Scores on PCS, MCS, EPIC summary scales (except sexual scale), and fear of progression did not change significantly over the study period (all P > 0.10).

conclusionOver the 2.5-year follow-up, QoL remained stable; only sexual function scores significantly declined. Illness uncertainty and anxiety were significant predictors of general and prostate-specific QoL and fear of progression. Interventions to reduce uncertainty and anxiety may enhance QoL for men with prostate cancer on AS.

Indexed as

Watchful WaitingAdultAgedAged, 80 and overAnxiety DisordersDisease ProgressionFearHumansMaleMiddle AgedProspective StudiesProstatic NeoplasmsQuality of LifeRisk FactorsUncertaintyactive surveillanceanxietyfearprostate cancerquality of lifewatchful waiting

Identifiers

PMID25714186
PMCPMC4547910

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.