ArticlePLoS genetics2015
microRNAs regulate cell-to-cell variability of endogenous target gene expression in developing mouse thymocytes.
Article in PLoS genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- Article
- Cell-to-cell variation in gene expression and the aging process.GeroScience · 2021Review
- Review
- Early microRNA indicators of PPARα pathway activation in the liver.Toxicology reports · 2020Article
- Gene regulatory network stabilized by pervasive weak repressions: microRNA functions revealed by the May-Wigner theory.National science review · 2019Article
- Single-cell mRNA profiling reveals the hierarchical response of miRNA targets to miRNA induction.Molecular systems biology · 2018Article
- MicroRNAs Establish Uniform Traits during the Architecture of Vertebrate Embryos.Developmental cell · 2017Article
- T-ALL and thymocytes: a message of noncoding RNAs.Journal of hematology & oncology · 2017Review
- Differential Sensitivity of Target Genes to Translational Repression by miR-17~92.PLoS genetics · 2017Article
- The Transcription Factor T-Bet Is Regulated by MicroRNA-155 in Murine Anti-Viral CD8Frontiers in immunology · 2017Article
- MicroRNAs as regulatory elements in immune system logic.Nature reviews. Immunology · 2016Review
- microRNAs calibrate T cell responses by regulating mTOR.Oncotarget · 2015Article
- Dietary MicroRNA Database (DMD): An Archive Database and Analytic Tool for Food-Borne microRNAs.PloS one · 2015Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
The development and homeostasis of multicellular organisms relies on gene regulation within individual constituent cells. Gene regulatory circuits that increase the robustness of gene expression frequently incorporate microRNAs as post-transcriptional regulators. Computational approaches, synthetic gene circuits and observations in model organisms predict that the co-regulation of microRNAs and their target mRNAs can reduce cell-to-cell variability in the expression of target genes. However, whether microRNAs directly regulate variability of endogenous gene expression remains to be tested in mammalian cells. Here we use quantitative flow cytometry to show that microRNAs impact on cell-to-cell variability of protein expression in developing mouse thymocytes. We find two distinct mechanisms that control variation in the activation-induced expression of the microRNA target CD69. First, the expression of miR-17 and miR-20a, two members of the miR-17-92 cluster, is co-regulated with the target mRNA Cd69 to form an activation-induced incoherent feed-forward loop. Another microRNA, miR-181a, acts at least in part upstream of the target mRNA Cd69 to modulate cellular responses to activation. The ability of microRNAs to render gene expression more uniform across mammalian cell populations may be important for normal development and for disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.