Evidence map›Paper›PMID 25713803›Full record

ReviewHepatobiliary surgery and nutrition2015

Contribution of bone marrow-derived fibrocytes to liver fibrosis.

Jun Xu, Min Cong, Tae Jun Park, David Scholten, David A Brenner, Tatiana Kisseleva

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Hepatobiliary surgery and nutrition, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 39 citations in OpenAlex.

  1. Circulating Fibrocytes: Cellular Mediators of Tissue Fibrosis.International journal of molecular sciences · 2026
    Review
  2. Article
  3. Review
  4. Mechanisms of prostatic inflammation-mediated male lower urinary tract symptoms.American journal of clinical and experimental urology · 2025
    Review
  5. Review
  6. Targeting Fibrosis: From Molecular Mechanisms to Advanced Therapies.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  7. Review
  8. Cancer-Associated Fibroblasts in Hepatocellular Carcinoma and Cholangiocarcinoma.Cellular and molecular gastroenterology and hepatology · 2023
    Review
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Molecular and cellular mechanisms of liver fibrosis and its regression.Nature reviews. Gastroenterology & hepatology · 2021
    Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jun Xu1 Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA ; 2 Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China ; 3 Department of Internal Medicine, Yonsei University College of Medicine, Seoul 120752, Korea ; 4 Department of Medicine III, University Hospital Aachen, Aachen 52074, Germany ; 5 Department of Surgery, University of California, San Diego, La Jolla, CA 92093, USA.
Min Cong1 Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA ; 2 Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China ; 3 Department of Internal Medicine, Yonsei University College of Medicine, Seoul 120752, Korea ; 4 Department of Medicine III, University Hospital Aachen, Aachen 52074, Germany ; 5 Department of Surgery, University of California, San Diego, La Jolla, CA 92093, USA.
Tae Jun Park1 Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA ; 2 Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China ; 3 Department of Internal Medicine, Yonsei University College of Medicine, Seoul 120752, Korea ; 4 Department of Medicine III, University Hospital Aachen, Aachen 52074, Germany ; 5 Department of Surgery, University of California, San Diego, La Jolla, CA 92093, USA.
David Scholten1 Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA ; 2 Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China ; 3 Department of Internal Medicine, Yonsei University College of Medicine, Seoul 120752, Korea ; 4 Department of Medicine III, University Hospital Aachen, Aachen 52074, Germany ; 5 Department of Surgery, University of California, San Diego, La Jolla, CA 92093, USA.
David A Brenner1 Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA ; 2 Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China ; 3 Department of Internal Medicine, Yonsei University College of Medicine, Seoul 120752, Korea ; 4 Department of Medicine III, University Hospital Aachen, Aachen 52074, Germany ; 5 Department of Surgery, University of California, San Diego, La Jolla, CA 92093, USA.
Tatiana Kisseleva1 Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA ; 2 Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China ; 3 Department of Internal Medicine, Yonsei University College of Medicine, Seoul 120752, Korea ; 4 Department of Medicine III, University Hospital Aachen, Aachen 52074, Germany ; 5 Department of Surgery, University of California, San Diego, La Jolla, CA 92093, USA.
University of California, San Diego · US

Funding

The Southernearch Center for ALPD and CirrhosisP50AA011999 · NIAAA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ANNA S. GUKOVSKAYA · 1999 to 2026
$45.8M
TNF ALPHA AND IMPAIRED WOUND HEALING OF CACHEXIA XIAR01GM041804 · NIGMS · UNIVERSITY OF NORTH CAROLINA CHAPEL HILL · PI BRENNER, DAVID A. · 1989 to 2013
$3.4M
Hepatic Stellate Cell Activation induced by Hepatitis C VirusR01AA015055 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BRENNER, DAVID A · 2003 to 2007
$1.9M
Angiotensin II and NADPH Oxidase in Hepatic FibrosisR01DK072237 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BRENNER, DAVID A. · 2005 to 2009
$1.7M
The Role of Fibrocytes in Liver FibrosisR56DK088837 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KISSELEVA, TATIANA · 2012 to 2012
$194k
NIAAA NIH HHS P50 AA011999NIAAA NIH HHS R01 AA015055NIDDK NIH HHS R01 DK072237NIDDK NIH HHS R56 DK088837NIGMS NIH HHS R01 GM041804
6 · The paper itself

Abstract

Since the discovery of fibrocytes in 1994 by Dr. Bucala and colleagues, these bone marrow (BM)-derived collagen Type I producing CD45(+) cells remain the most fascinating cells of the hematopoietic system. Despite recent reports on the emerging contribution of fibrocytes to fibrosis of parenchymal and non-parenchymal organs and tissues, fibrocytes remain the most understudied pro-fibrogenic cellular population. In the past years fibrocytes were implicated in the pathogenesis of liver, skin, lung, and kidney fibrosis by giving rise to collagen type I producing cells/myofibroblasts. Hence, the role of fibrocytes in fibrosis is not well defined since different studies often contain controversial results on the number of fibrocytes recruited to the site of injury versus the number of fibrocyte-derived myofibroblasts in the same fibrotic organ. Furthermore, many studies were based on the in vitro characterization of fibrocytes formed after outgrowth of BM and/or peripheral blood cultures. Therefore, the fibrocyte function(s) still remain(s) lack of understanding, mostly due to (I) the lack of mouse models that can provide complimentary in vivo real-time and cell fate mapping studies of the dynamic differentiation of fibrocytes and their progeny into collagen type I producing cells (and/or possibly, other cell types of the hematopoietic system); (II) the complexity of hematopoietic cell differentiation pathways in response to various stimuli; (III) the high plasticity of hematopoietic cells. Here we summarize the current understanding of the role of CD45(+) collagen type I(+) BM-derived cells in the pathogenesis of liver injury. Based on data obtained from various organs undergoing fibrogenesis or other type of chronic injury, here we also discuss the most recent evidence supporting the critical role of fibrocytes in the mediation of pro-fibrogenic and/or pro-inflammatory responses.

Indexed as

Fibrocytesmigrationmyofibroblasts

Identifiers

PMID25713803
PMCPMC4318956
OpenAlexW2180267890

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.