Evidence map›Paper›PMID 25713706›Full record

ArticleClinical kidney journal2015

Extracellular vesicles in the urine: markers and mediators of tissue damage and regeneration.

Andrea Ranghino, Veronica Dimuccio, Elli Papadimitriou, Benedetta Bussolati

Abstract read
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In one paragraph

Article in Clinical kidney journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed.

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  16. Farewell from theClinical kidney journal · 2022
    Article
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  20. Extracellular Vesicles in Acute Kidney Injury and Clinical Applications.International journal of molecular sciences · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Andrea RanghinoDepartment of Molecular Biotechnology and Health Sciences , University of Torino , Torino , Italy ; Department of Medical Sciences , University of Torino , Torino , Italy.
Veronica DimuccioDepartment of Molecular Biotechnology and Health Sciences , University of Torino , Torino , Italy.
Elli PapadimitriouDepartment of Molecular Biotechnology and Health Sciences , University of Torino , Torino , Italy.
Benedetta BussolatiDepartment of Molecular Biotechnology and Health Sciences , University of Torino , Torino , Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As in several body fluids, urine is a rich reservoir of extracellular vesicles (EVs) directly originating from cells facing the urinary lumen, including differentiated tubular cells, progenitor cells and infiltrating inflammatory cells. Several markers of glomerular and tubular damage, such as WT-1, ATF3 and NGAL, as well as of renal regeneration, such as CD133, have been identified representing an incredible source of information for diagnostic purposes. In addition, urinary extracellular vesicles (uEVs) appear to be involved in the cell-to-cell communication along the nephron, although this aspect needs further elucidation. Finally, uEVs emerge as potential amplifying or limiting factors in renal damage. Vesicles from injured cells may favour fibrosis and disease progression whereas those from cells with regenerative potential appear to promote cell survival. Here, we will discuss the most recent findings of the literature, on the light of the role of EVs in diagnosis and therapy for damage and repair of the renal tissue.

Indexed as

biomarkersexosomeskidney injuryprogenitor cellsurine

Identifiers

PMID25713706
PMCPMC4310438

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.