Evidence map›Paper›PMID 25713607›Full record

ReviewJournal of medicine and life

The regulator of calcineurin (RCAN1) an important factor involved in atherosclerosis and cardiovascular diseases development.

E Torac, L Gaman, V Atanasiu

Open access · greenAbstract readReview
In one paragraph

Review in Journal of medicine and life. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Oxidative stress-mediated neuroinflammation in Alzheimer's disease.Naunyn-Schmiedeberg's archives of pharmacology · 2024
    Review
  5. Review
  6. Article
  7. Downregulation of oxytocin-related genes in periodontitis.Frontiers in molecular neuroscience · 2022
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. What people with Down Syndrome can teach us about cardiopulmonary disease.European respiratory review : an official journal of the European Respiratory Society · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

E ToracBiochemistry Department, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
L GamanBiochemistry Department, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
V AtanasiuBiochemistry Department, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
Carol Davila University of Medicine and Pharmacy · RO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atherosclerosis, one of the main causes of cardiovascular diseases, is a complex process that involves manifold factors. Besides the vascular lipids accumulation, inflammatory factors could be considered as a proatherogenic factor - RCAN1. RCAN1 is a regulator of calcineurin, both of them being calcium dependent proteins. Recent studies have shown that RCAN1 has an important role in heart valve development. In the same time researchers found that, the atherosclerotic plaques have an up-regulated RCAN1 gene expression. In the near future, it is desirable to elucidate the RCAN1 function and classify it as a possible biochemical marker to diagnose infancy atherosclerosis.

Indexed as

Disease ProgressionAtherosclerosisCalcineurinCardiovascular SystemHumansModels, BiologicalMuscle ProteinsCalcineurinMuscle Proteinsatherosclerosiscalcineurincardiovascular diseaseDown SyndromeRCAN1

Identifiers

PMID25713607
PMCPMC4316123
OpenAlexW130135146

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.