ArticleFrontiers in neurology2015
Noise Trauma Induced Neural Plasticity Throughout the Auditory System of Mongolian Gerbils: Differences between Tinnitus Developing and Non-Developing Animals.
Article in Frontiers in neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 41 citations in OpenAlex.
- Elucidating the neuromeric organization of the Mongolian gerbil brain.Brain structure & function · 2025Article
- Transcriptional profile changes caused by noise-induced tinnitus in the cochlear nucleus and inferior colliculus of the rat.Annals of medicine · 2024Article
- Tinnitus is associated with increased extracellular matrix density in the auditory cortex of Mongolian gerbils.BMC neuroscience · 2024Article
- Cortical evoked activity is modulated by the sleep state in a ferret model of tinnitus. A cross-case study.PloS one · 2024Article
- Differential cortical activation patterns: pioneering sub-classification of tinnitus with and without hyperacusis by combining audiometry, gamma oscillations, and hemodynamics.Frontiers in neuroscience · 2023Article
- Preventive Effects of Ginkgo-Extract EGb 761Nutrients · 2022Article
- Behavioral and Immunohistochemical Evidence for Suppressive Effects of Goshajinkigan on Salicylate-Induced Tinnitus in Rats.Brain sciences · 2022Article
- Intrinsic Noise Improves Speech Recognition in a Computational Model of the Auditory Pathway.Frontiers in neuroscience · 2022Article
- Circadian Sensitivity of Noise Trauma-Induced Hearing Loss and Tinnitus in Mongolian Gerbils.Frontiers in neuroscience · 2022Article
- Cortical oscillatory dysrhythmias in visual snow syndrome: a magnetoencephalography study.Brain communications · 2022Article
- Article
- Salicylate-Induced Changes in Hearing Thresholds in Mongolian Gerbils Are Correlated With Tinnitus Frequency but Not With Tinnitus Strength.Frontiers in behavioral neuroscience · 2021Article
- The Neural Bases of Tinnitus: Lessons from Deafness and Cochlear Implants.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Review
- Acute and Long-Term Circuit-Level Effects in the Auditory Cortex After Sound Trauma.Frontiers in neuroscience · 2020Article
- Objective Estimation of Sensory Thresholds Based on Neurophysiological Parameters.Frontiers in neuroscience · 2019Article
- Cochlear Synaptopathy Changes Sound-Evoked Activity Without Changing Spontaneous Discharge in the Mouse Inferior Colliculus.Frontiers in systems neuroscience · 2018Article
- Cross-Modal Stochastic Resonance as a Universal Principle to Enhance Sensory Processing.Frontiers in neuroscience · 2018Article
- A New Statistical Approach for the Evaluation of Gap-prepulse Inhibition of the Acoustic Startle Reflex (GPIAS) for Tinnitus Assessment.Frontiers in behavioral neuroscience · 2017Article
- Maladaptive plasticity in tinnitus--triggers, mechanisms and treatment.Nature reviews. Neurology · 2016Review
- Stochastic Resonance Controlled Upregulation of Internal Noise after Hearing Loss as a Putative Cause of Tinnitus-Related Neuronal Hyperactivity.Frontiers in neuroscience · 2016Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, we describe differences between neural plasticity in auditory cortex (AC) of animals that developed subjective tinnitus (group T) after noise-induced hearing loss (NIHL) compared to those that did not [group non-tinnitus (NT)]. To this end, our analysis focuses on the input activity of cortical neurons based on the temporal and spectral analysis of local field potential (LFP) recordings and an in-depth analysis of auditory brainstem responses (ABR) in the same animals. In response to NIHL in NT animals we find a significant general reduction in overall cortical activity and spectral power as well as changes in all ABR wave amplitudes as a function of loudness. In contrast, T-animals show no significant change in overall cortical activity as assessed by root mean square analysis of LFP amplitudes, but a specific increase in LFP spectral power and in the amplitude of ABR wave V reflecting activity in the inferior colliculus (IC). Based on these results, we put forward a refined model of tinnitus prevention after NIHL that acts via a top-down global (i.e., frequency-unspecific) inhibition reducing overall neuronal activity in AC and IC, thereby counteracting NIHL-induced bottom-up frequency-specific neuroplasticity suggested in current models of tinnitus development.
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