ReviewFrontiers in pharmacology2015
Early steps in inner ear development: induction and morphogenesis of the otic placode.
Review in Frontiers in pharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 53 citations in OpenAlex.
- Inner Ear Organoids: Recent Progress and Challenges.Stem cell reviews and reports · 2026Review
- Single-cell, clonal and spatial atlases of cranial placodes illuminate their specification and evolution.bioRxiv : the preprint server for biology · 2026Article
- Lipid-mediated reinforcement of FGF/MAPK signaling enables robust otic placode specification.bioRxiv : the preprint server for biology · 2026Article
- Persistent and Dose-Dependent Neural and Metabolic Gene Expression Changes Induced by Transient Citalopram Exposure in Zebrafish Embryos.International journal of molecular sciences · 2025Article
- Article
- Development of the semicircular canals and otolithic organs of the vertebrate inner ear.Current topics in developmental biology · 2025Review
- Differentiation of Spiral Ganglion Neurons from Human Dental Pulp Stem Cells: A Further Step towards Autologous Auditory Nerve Recovery.International journal of molecular sciences · 2024Article
- Shared features in ear and kidney development - implications for oto-renal syndromes.Disease models & mechanisms · 2024Article
- Transcriptome analysis reveals an Atoh1b-dependent gene set downstream of Dlx3b/4b during early inner ear development in zebrafish.Biology open · 2023Article
- New developments in the biology of fibroblast growth factors.WIREs mechanisms of disease · 2022Review
- Directed Differentiation of Human Pluripotent Stem Cells into Inner Ear Organoids.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Embryology, Malformations, and Rare Diseases of the Cochlea.Laryngo- rhino- otologie · 2021Article
- Multimodal Atlas of the Murine Inner Ear: From Embryo to Adult.Frontiers in neurology · 2021Article
- Building inner ears: recent advances and future challenges for in vitro organoid systems.Cell death and differentiation · 2021Review
- Review
- Sculpting the skull through neurosensory epithelial-mesenchymal signaling.Developmental dynamics : an official publication of the American Association of Anatomists · 2019Review
- Hearing crosstalk: the molecular conversation orchestrating inner ear dorsoventral patterning.Wiley interdisciplinary reviews. Developmental biology · 2018Review
- Target sequencing of 307 deafness genes identifies candidate genes implicated in microtia.Oncotarget · 2017Article
- A gene network regulated by FGF signalling during ear development.Scientific reports · 2017Article
- Epithelial Folding Driven by Apical or Basal-Lateral Modulation: Geometric Features, Mechanical Inference, and Boundary Effects.Biophysical journal · 2017Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Various cellular replacement therapies using in vitro generated cells to replace damaged tissue have been proposed as strategies to alleviate hearing loss. All such therapies must involve a complete understanding of the earliest steps in inner ear development; its induction as a thickened plate of cells in the non-neural, surface ectoderm of the embryo, to its internalization as an otocyst embedded in the head mesenchyme of the embryo. Such knowledge informs researchers addressing the feasibility of the proposed strategy and present alternatives if needed. In this review we describe the mechanisms of inner ear induction, concentrating on the factors that steer the fate of ectoderm into precursors of the inner ear. Induction then leads to inner ear morphogenesis and we describe the cellular changes that occur as the inner ear is converted from a superficial placode to an internalized otocyst, and how they are coordinated with a particular emphasis on how the signaling environment surrounding the inner ear influences these processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.