ArticleThe Journal of cell biology2015
Three distinct ribosome assemblies modulated by translation are the building blocks of polysomes.
Article in The Journal of cell biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 46 citations in OpenAlex.
- Circularization and Ribosome Recycling: From Polysome Topology to Translational Control.International journal of molecular sciences · 2026Review
- Piwil2 (Mili) sustains neurogenesis and prevents cellular senescence in the postnatal hippocampus.EMBO reports · 2023Article
- A transformation clustering algorithm and its application in polyribosomes structural profiling.Nucleic acids research · 2022Article
- Localization of a TORC1-eIF4F translation complex during CD8Molecular cell · 2022Article
- Impaired dynamic interaction of axonal endoplasmic reticulum and ribosomes contributes to defective stimulus-response in spinal muscular atrophy.Translational neurodegeneration · 2022Article
- Incoming new IUPAB Councilor 2021-Gabriella Viero.Biophysical reviews · 2021Article
- DHX30 Coordinates Cytoplasmic Translation and Mitochondrial Function Contributing to Cancer Cell Survival.Cancers · 2021Article
- Review
- Stochastic microswimming model of ribosome motion on the polysome.The European physical journal. E, Soft matter · 2021Article
- What determines eukaryotic translation elongation: recent molecular and quantitative analyses of protein synthesis.Open biology · 2020Review
- SMN-primed ribosomes modulate the translation of transcripts related to spinal muscular atrophy.Nature cell biology · 2020Article
- Ribosome-associated vesicles: A dynamic subcompartment of the endoplasmic reticulum in secretory cells.Science advances · 2020Article
- Targeting Translation Activity at the Ribosome Interface with UV-Active Small Molecules.ACS omega · 2019Article
- mRNP architecture in translating and stress conditions reveals an ordered pathway of mRNP compaction.The Journal of cell biology · 2018Article
- Spatial Organization of Single mRNPs at Different Stages of the Gene Expression Pathway.Molecular cell · 2018Article
- Article
- Hydrogen peroxide is a neuronal alarmin that triggers specific RNAs, local translation of Annexin A2, and cytoskeletal remodeling in Schwann cells.RNA (New York, N.Y.) · 2018Article
- The Making and Breaking of Inositol 1,4,5-Trisphosphate Receptor Tetramers.Messenger (Los Angeles, Calif. : Print) · 2018Article
- Identification and dynamic changes of RNAs isolated from RALY-containing ribonucleoprotein complexes.Nucleic acids research · 2017Article
- Peering at Brain Polysomes with Atomic Force Microscopy.Journal of visualized experiments : JoVE · 2016Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
Abstract
Translation is increasingly recognized as a central control layer of gene expression in eukaryotic cells. The overall organization of mRNA and ribosomes within polysomes, as well as the possible role of this organization in translation are poorly understood. Here we show that polysomes are primarily formed by three distinct classes of ribosome assemblies. We observe that these assemblies can be connected by naked RNA regions of the transcript. We show that the relative proportions of the three classes of ribosome assemblies reflect, and probably dictate, the level of translational activity. These results reveal the existence of recurrent supra-ribosomal building blocks forming polysomes and suggest the presence of unexplored translational controls embedded in the polysome structure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.