ArticlePhysiological reports2015
Impact of ischemic preconditioning on functional sympatholysis during handgrip exercise in humans.
Article in Physiological reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Ischemic preconditioning and exercise performance: shedding light through smallest worthwhile change.European journal of applied physiology · 2019Pooled it
- The Effects of Ischemic Preconditioning on Human Exercise Performance.Sports medicine (Auckland, N.Z.) · 2016Pooled it
- Leg fidgeting alleviates reduced oxygen extraction in the gastrocnemius muscle caused by prolonged sitting: a randomized crossover trial.European journal of applied physiology · 2025Trial
- Blood flow restriction in the presence or absence of muscle contractions does not preserve vasculature structure and function following 14-days of limb immobilization.European journal of applied physiology · 2021Trial
- Cardiac autonomic recovery following traditional and augmented remote ischemic preconditioning.European journal of applied physiology · 2021Trial
- Muscle oxygenation profiles between active and inactive muscles with nitrate supplementation under hypoxic exercise.Physiological reports · 2017Trial
- Ischemic preconditioning reduces hemodynamic response during metaboreflex activation.American journal of physiology. Regulatory, integrative and comparative physiology · 2016Trial
- Ischemic preconditioning combined with inter-set palm cooling enhances performance in strength-trained men during high-intensity resistance training: A randomized crossover trial.Biology of sport · 2026Article
- Acute effects of ischemic preconditioning and isometric exercise on blood pressure in prehypertensive males.Journal of exercise science and fitness · 2025Article
- Influence of local and remote ischemic preconditioning on 3-min all-out exercise performance: A randomized controlled crossover study.Journal of exercise science and fitness · 2025Article
- Potential Short- and Long-Term Physiological Effects of Ischemic Preconditioning as an Ergogenic Aid: Revisiting Foundational Mechanisms and Applications.Sports medicine (Auckland, N.Z.) · 2025Review
- The effects of blood flow restriction combined with endurance training on athletes' aerobic capacity, lower limb muscle strength, anaerobic power and sports performance: a meta-analysis.BMC sports science, medicine & rehabilitation · 2025Article
- Article
- The Acute Effects of Ischemic Preconditioning on Short-Duration Cycling: A Randomized Crossover Study.International journal of exercise science · 2023Article
- Ischaemic preconditioning blunts exercise-induced mitochondrial dysfunction, speeds oxygen uptake kinetics but does not alter severe-intensity exercise capacity.Experimental physiology · 2022Article
- Effects of isometric leg training on ambulatory blood pressure and morning blood pressure surge in young normotensive men and women.Scientific reports · 2022Article
- Potential physiological responses contributing to the ergogenic effects of acute ischemic preconditioning during exercise: A narrative review.Frontiers in physiology · 2022Review
- Effects of arm cranking exercise on muscle oxygenation between active and inactive muscles in people with spinal cord injury.The journal of spinal cord medicine · 2021Observational
- The Effects of Ischemia During Rest Intervals on Bar Velocity in the Bench Press Exercise With Different External Loads.Frontiers in physiology · 2021Article
- The effect of IPC on central and peripheral fatiguing mechanisms in humans following maximal single limb isokinetic exercise.Physiological reports · 2019Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Repeated bouts of ischemia followed by reperfusion, known as ischemic preconditioning (IPC), is found to improve exercise performance. As redistribution of blood from the inactive areas to active skeletal muscles during exercise (i.e., functional sympatholysis) is important for exercise performance, we examined the hypothesis that IPC improves functional sympatholysis in healthy, young humans. In a randomized study, 15 healthy young men performed a 10-min resting period, dynamic handgrip exercise at 10% maximal voluntary contraction (MVC), and 25% MVC. This protocol was preceded by IPC (IPC; 4 × 5-min 220-mmHg unilateral occlusion) or a sham intervention (CON; 4 × 5-min 20-mmHg unilateral occlusion). Near-infrared spectroscopy was used to assess changes in oxygenated hemoglobin and myoglobin in skeletal muscle (HbO2 + MbO2) in response to sympathetic activation (via cold pressor test (CPT)) at baseline and during handgrip exercise (at 10% and 25%). In resting conditions, HbO2 + MbO2 significantly decreased during CPT (-11.0 ± 1.0%), which was significantly larger during the IPC-trial (-13.8 ± 1.2%, P = 0.006). During handgrip exercise at 10% MVC, changes in HbO2 + MbO2 in response to the CPT were blunted after IPC (-8.8 ± 1.5%) and CON (-8.3 ± 0.4%, P = 0.593). During handgrip exercise at 25% MVC, HbO2 + MbO2 in response to the CPT increased (2.0 ± 0.4%), whereas this response was significantly larger when preceded by IPC (4.2 ± 0.6%, P = 0.027). Collectively, these results indicate that IPC-induced different vascular changes at rest and during moderate exercise in response to sympathetic activation. This suggests that, in healthy volunteers, exposure to IPC may alter tissue oxygenation during sympathetic stimulation at rest and during exercise.
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