Evidence map›Paper›PMID 25713318›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2015

Estradiol improves right ventricular function in rats with severe angioproliferative pulmonary hypertension: effects of endogenous and exogenous sex hormones.

Andrea L Frump, Kara N Goss, Alexandra Vayl, Marjorie Albrecht, Amanda Fisher, Roziya Tursunova, John Fierst, Jordan Whitson, Anthony R Cucci, M Beth Brown and 1 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 108 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
108citing papers in PubMed, 1 pooled it
11.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

108 citing papers in PubMed, 1 synthesis or guideline pooled it, 158 citations in OpenAlex.

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48 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Andrea L FrumpDivision of Pulmonary, Allergy, Critical Care, Occupational and Sleep Medicine; Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana;
Kara N GossDivision of Pulmonary, Allergy, Critical Care, Occupational and Sleep Medicine; Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana;
Alexandra VaylDivision of Pulmonary, Allergy, Critical Care, Occupational and Sleep Medicine; Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana;
Marjorie AlbrechtDivision of Pulmonary, Allergy, Critical Care, Occupational and Sleep Medicine; Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana;
Amanda FisherDepartment of Anesthesiology, Indiana University School of Medicine, Indianapolis, Indiana;
Roziya TursunovaDivision of Pulmonary, Allergy, Critical Care, Occupational and Sleep Medicine; Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana;
John FierstDivision of Pulmonary, Allergy, Critical Care, Occupational and Sleep Medicine; Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana;
Jordan WhitsonDivision of Pulmonary, Allergy, Critical Care, Occupational and Sleep Medicine; Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana;
Anthony R CucciDivision of Pulmonary, Allergy, Critical Care, Occupational and Sleep Medicine; Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana;
M Beth BrownDepartment of Physical Therapy, Indiana University School of Health and Rehabilitation Sciences;
Tim LahmDivision of Pulmonary, Allergy, Critical Care, Occupational and Sleep Medicine; Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana; Center for Immunobiology, Indiana University School of Medicine, Indianapolis, Indiana; and Richard L. Roudebush VA Medical Center, Indianapolis, Indiana tlahm@iu.edu.
Indiana University – Purdue University Indianapolis · USIndiana University School of MedicineIndiana University · US

Funding

IU Training Program in Molecular Physiology and Clinical Mechanisms of Lung DiseaseT32HL091816 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI Erick Forno, Roberto F. Machado · 2009 to 2026
$4.3M
Hypoxia-mediated protective estrogen receptor signaling in pulmonary hypertensionI01BX002042 · VA · VA EASTERN COLORADO HEALTH CARE SYSTEM · PI Tim Lahm · 2014 to 2026
–
BLRD VA I01 BX002042NHLBI NIH HHS 5T32HL091816-05NHLBI NIH HHS T32 HL091816
6 · The paper itself

Abstract

Estrogens are disease modifiers in PAH. Even though female patients exhibit better right ventricular (RV) function than men, estrogen effects on RV function (a major determinant of survival in PAH) are incompletely characterized. We sought to determine whether sex differences exist in RV function in the SuHx model of PAH, whether hormone depletion in females worsens RV function, and whether E2 repletion improves RV adaptation. Furthermore, we studied the contribution of ERs in mediating E2's RV effects. SuHx-induced pulmonary hypertension (SuHx-PH) was induced in male and female Sprague-Dawley rats as well as OVX females with or without concomitant E2 repletion (75 μg·kg(-1)·day(-1)). Female SuHx rats exhibited superior CI than SuHx males. OVX worsened SuHx-induced decreases in CI and SuHx-induced increases in RVH and inflammation (MCP-1 and IL-6). E2 repletion in OVX rats attenuated SuHx-induced increases in RV systolic pressure (RVSP), RVH, and pulmonary artery remodeling and improved CI and exercise capacity (V̇o2max). Furthermore, E2 repletion ameliorated SuHx-induced alterations in RV glutathione activation, proapoptotic signaling, cytoplasmic glycolysis, and proinflammatory cytokine expression. Expression of ERα in RV was decreased in SuHx-OVX but was restored upon E2 repletion. RV ERα expression was inversely correlated with RVSP and RVH and positively correlated with CO and apelin RNA levels. RV-protective E2 effects observed in females were recapitulated in male SuHx rats treated with E2 or with pharmacological ERα or ERβ agonists. Our data suggest significant RV-protective ER-mediated effects of E2 in a model of severe PH.

Indexed as

AnimalsApelinApoptosisBlood PressureBody WeightCytokinesEstradiolEstrogen Receptor alphaEstrogen Receptor betaFemaleHypertension, PulmonaryHypertrophy, Right VentricularInflammationIntercellular Signaling Peptides and ProteinsMaleOvariectomyApelinApln protein, ratCytokinesEstradiolEstrogen Receptor alphaEstrogen Receptor betaIntercellular Signaling Peptides and Proteinsapoptosisestrogen receptorexercise capacityright ventricular failuresex differences

Identifiers

PMID25713318
PMCPMC4421786
OpenAlexW2038311789

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.