ArticleJournal of the National Cancer Institute2015
A prospective study of the immune system activation biomarker neopterin and colorectal cancer risk.
Open access · bronzeAbstract read
In one paragraph
Article in Journal of the National Cancer Institute, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 18 citations in OpenAlex.
- Protein Biomarkers of Gastric Preneoplasia and Cancer Lesions in Blood: A Comprehensive Review.Cancers · 2024Review
- Exploratory Evaluation of Neopterin and Chitotriosidase as Potential Circulating Biomarkers for Colorectal Cancer.Biomedicines · 2023Article
- Article
- Association of Chemerin Plasma Concentration With Risk of Colorectal Cancer.JAMA network open · 2019Article
- Plasma miRNA can detect colorectal cancer, but how early?Cancer medicine · 2018Article
- Nephronectin is Correlated with Poor Prognosis in Breast Cancer and Promotes Metastasis via its Integrin-Binding Motifs.Neoplasia (New York, N.Y.) · 2018Article
- A prospective evaluation of serum kynurenine metabolites and risk of pancreatic cancer.PloS one · 2018Article
- Physical activity, mediating factors and risk of colon cancer: insights into adiposity and circulating biomarkers from the EPIC cohort.International journal of epidemiology · 2017Article
- Biomarkers of Inflammation and Immune Function and Risk of Colorectal Cancer.Current colorectal cancer reportsReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
47 authors at 8 institutions in 5 countries.
Krasimira AleksandrovaDepartment of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrueke, Nuthetal, Germany (KA, HB); Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK (SCC, BBdM, MJG, YL, AJC, ER, PV); Division of Health Policy Translation, Institutes of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan (SCC); Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway (HZ, GST); Molecular Epidemiology Group, Max Delbrueck Center for Molecular Medicine, Berlin-Buch, Germany (TP); International Agency for Research on Cancer, Lyon, France (MJe, SYJK, HF, MJo); National Institute for Public Health and the Environment, Bilthoven, the Netherlands (BBdM); Department of Gastroenterology and Hepatology, University Medical Center, Utrecht, the Netherlands (BBdM); Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway (SEV); Division of Epidemiology, Norwegian Institute of Public Health, Bergen, Norway (SEV); Bevital AS, Bergen, Norway (ØM); Section for Pharmacology, Department of Clinical Science, University of Bergen, Bergen, Norway (HZ, PMU); Laboratory of Clinical Biochemistry, Haukeland University Hospital, Bergen, Norway (PMU); Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA (VF); Winship Cancer Institute, Emory University, Atlanta, GA (VF); Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway (EW); Department of Research, Cancer Registry of Norway, Oslo, Norway (EW); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (EW); Samfundet Folkhälsan, Helsinki, Finland (EW); Human Genetics Foundation (HuGeF), Torino, Italy (GS, PV); Inserm, Centre for research in Epidemiology and Population Health, U1018, Nutrition, Hormones and Women's Health team, F-94805, Villeju
Shu-Chun ChuangDepartment of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrueke, Nuthetal, Germany (KA, HB); Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK (SCC, BBdM, MJG, YL, AJC, ER, PV); Division of Health Policy Translation, Institutes of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan (SCC); Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway (HZ, GST); Molecular Epidemiology Group, Max Delbrueck Center for Molecular Medicine, Berlin-Buch, Germany (TP); International Agency for Research on Cancer, Lyon, France (MJe, SYJK, HF, MJo); National Institute for Public Health and the Environment, Bilthoven, the Netherlands (BBdM); Department of Gastroenterology and Hepatology, University Medical Center, Utrecht, the Netherlands (BBdM); Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway (SEV); Division of Epidemiology, Norwegian Institute of Public Health, Bergen, Norway (SEV); Bevital AS, Bergen, Norway (ØM); Section for Pharmacology, Department of Clinical Science, University of Bergen, Bergen, Norway (HZ, PMU); Laboratory of Clinical Biochemistry, Haukeland University Hospital, Bergen, Norway (PMU); Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA (VF); Winship Cancer Institute, Emory University, Atlanta, GA (VF); Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway (EW); Department of Research, Cancer Registry of Norway, Oslo, Norway (EW); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (EW); Samfundet Folkhälsan, Helsinki, Finland (EW); Human Genetics Foundation (HuGeF), Torino, Italy (GS, PV); Inserm, Centre for research in Epidemiology and Population Health, U1018, Nutrition, Hormones and Women's Health team, F-94805, Villeju
Heiner BoeingDepartment of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrueke, Nuthetal, Germany (KA, HB); Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK (SCC, BBdM, MJG, YL, AJC, ER, PV); Division of Health Policy Translation, Institutes of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan (SCC); Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway (HZ, GST); Molecular Epidemiology Group, Max Delbrueck Center for Molecular Medicine, Berlin-Buch, Germany (TP); International Agency for Research on Cancer, Lyon, France (MJe, SYJK, HF, MJo); National Institute for Public Health and the Environment, Bilthoven, the Netherlands (BBdM); Department of Gastroenterology and Hepatology, University Medical Center, Utrecht, the Netherlands (BBdM); Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway (SEV); Division of Epidemiology, Norwegian Institute of Public Health, Bergen, Norway (SEV); Bevital AS, Bergen, Norway (ØM); Section for Pharmacology, Department of Clinical Science, University of Bergen, Bergen, Norway (HZ, PMU); Laboratory of Clinical Biochemistry, Haukeland University Hospital, Bergen, Norway (PMU); Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA (VF); Winship Cancer Institute, Emory University, Atlanta, GA (VF); Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway (EW); Department of Research, Cancer Registry of Norway, Oslo, Norway (EW); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (EW); Samfundet Folkhälsan, Helsinki, Finland (EW); Human Genetics Foundation (HuGeF), Torino, Italy (GS, PV); Inserm, Centre for research in Epidemiology and Population Health, U1018, Nutrition, Hormones and Women's Health team, F-94805, Villeju
Hui ZuoDepartment of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrueke, Nuthetal, Germany (KA, HB); Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK (SCC, BBdM, MJG, YL, AJC, ER, PV); Division of Health Policy Translation, Institutes of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan (SCC); Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway (HZ, GST); Molecular Epidemiology Group, Max Delbrueck Center for Molecular Medicine, Berlin-Buch, Germany (TP); International Agency for Research on Cancer, Lyon, France (MJe, SYJK, HF, MJo); National Institute for Public Health and the Environment, Bilthoven, the Netherlands (BBdM); Department of Gastroenterology and Hepatology, University Medical Center, Utrecht, the Netherlands (BBdM); Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway (SEV); Division of Epidemiology, Norwegian Institute of Public Health, Bergen, Norway (SEV); Bevital AS, Bergen, Norway (ØM); Section for Pharmacology, Department of Clinical Science, University of Bergen, Bergen, Norway (HZ, PMU); Laboratory of Clinical Biochemistry, Haukeland University Hospital, Bergen, Norway (PMU); Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA (VF); Winship Cancer Institute, Emory University, Atlanta, GA (VF); Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway (EW); Department of Research, Cancer Registry of Norway, Oslo, Norway (EW); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (EW); Samfundet Folkhälsan, Helsinki, Finland (EW); Human Genetics Foundation (HuGeF), Torino, Italy (GS, PV); Inserm, Centre for research in Epidemiology and Population Health, U1018, Nutrition, Hormones and Women's Health team, F-94805, Villeju
Grethe S TellDepartment of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrueke, Nuthetal, Germany (KA, HB); Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK (SCC, BBdM, MJG, YL, AJC, ER, PV); Division of Health Policy Translation, Institutes of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan (SCC); Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway (HZ, GST); Molecular Epidemiology Group, Max Delbrueck Center for Molecular Medicine, Berlin-Buch, Germany (TP); International Agency for Research on Cancer, Lyon, France (MJe, SYJK, HF, MJo); National Institute for Public Health and the Environment, Bilthoven, the Netherlands (BBdM); Department of Gastroenterology and Hepatology, University Medical Center, Utrecht, the Netherlands (BBdM); Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway (SEV); Division of Epidemiology, Norwegian Institute of Public Health, Bergen, Norway (SEV); Bevital AS, Bergen, Norway (ØM); Section for Pharmacology, Department of Clinical Science, University of Bergen, Bergen, Norway (HZ, PMU); Laboratory of Clinical Biochemistry, Haukeland University Hospital, Bergen, Norway (PMU); Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA (VF); Winship Cancer Institute, Emory University, Atlanta, GA (VF); Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway (EW); Department of Research, Cancer Registry of Norway, Oslo, Norway (EW); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (EW); Samfundet Folkhälsan, Helsinki, Finland (EW); Human Genetics Foundation (HuGeF), Torino, Italy (GS, PV); Inserm, Centre for research in Epidemiology and Population Health, U1018, Nutrition, Hormones and Women's Health team, F-94805, Villeju
Tobias PischonDepartment of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrueke, Nuthetal, Germany (KA, HB); Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK (SCC, BBdM, MJG, YL, AJC, ER, PV); Division of Health Policy Translation, Institutes of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan (SCC); Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway (HZ, GST); Molecular Epidemiology Group, Max Delbrueck Center for Molecular Medicine, Berlin-Buch, Germany (TP); International Agency for Research on Cancer, Lyon, France (MJe, SYJK, HF, MJo); National Institute for Public Health and the Environment, Bilthoven, the Netherlands (BBdM); Department of Gastroenterology and Hepatology, University Medical Center, Utrecht, the Netherlands (BBdM); Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway (SEV); Division of Epidemiology, Norwegian Institute of Public Health, Bergen, Norway (SEV); Bevital AS, Bergen, Norway (ØM); Section for Pharmacology, Department of Clinical Science, University of Bergen, Bergen, Norway (HZ, PMU); Laboratory of Clinical Biochemistry, Haukeland University Hospital, Bergen, Norway (PMU); Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA (VF); Winship Cancer Institute, Emory University, Atlanta, GA (VF); Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway (EW); Department of Research, Cancer Registry of Norway, Oslo, Norway (EW); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (EW); Samfundet Folkhälsan, Helsinki, Finland (EW); Human Genetics Foundation (HuGeF), Torino, Italy (GS, PV); Inserm, Centre for research in Epidemiology and Population Health, U1018, Nutrition, Hormones and Women's Health team, F-94805, Villeju
Mazda JenabDepartment of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrueke, Nuthetal, Germany (KA, HB); Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK (SCC, BBdM, MJG, YL, AJC, ER, PV); Division of Health Policy Translation, Institutes of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan (SCC); Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway (HZ, GST); Molecular Epidemiology Group, Max Delbrueck Center for Molecular Medicine, Berlin-Buch, Germany (TP); International Agency for Research on Cancer, Lyon, France (MJe, SYJK, HF, MJo); National Institute for Public Health and the Environment, Bilthoven, the Netherlands (BBdM); Department of Gastroenterology and Hepatology, University Medical Center, Utrecht, the Netherlands (BBdM); Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway (SEV); Division of Epidemiology, Norwegian Institute of Public Health, Bergen, Norway (SEV); Bevital AS, Bergen, Norway (ØM); Section for Pharmacology, Department of Clinical Science, University of Bergen, Bergen, Norway (HZ, PMU); Laboratory of Clinical Biochemistry, Haukeland University Hospital, Bergen, Norway (PMU); Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA (VF); Winship Cancer Institute, Emory University, Atlanta, GA (VF); Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway (EW); Department of Research, Cancer Registry of Norway, Oslo, Norway (EW); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (EW); Samfundet Folkhälsan, Helsinki, Finland (EW); Human Genetics Foundation (HuGeF), Torino, Italy (GS, PV); Inserm, Centre for research in Epidemiology and Population Health, U1018, Nutrition, Hormones and Women's Health team, F-94805, Villeju
Bas Bueno-de-MesquitaDepartment of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrueke, Nuthetal, Germany (KA, HB); Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK (SCC, BBdM, MJG, YL, AJC, ER, PV); Division of Health Policy Translation, Institutes of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan (SCC); Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway (HZ, GST); Molecular Epidemiology Group, Max Delbrueck Center for Molecular Medicine, Berlin-Buch, Germany (TP); International Agency for Research on Cancer, Lyon, France (MJe, SYJK, HF, MJo); National Institute for Public Health and the Environment, Bilthoven, the Netherlands (BBdM); Department of Gastroenterology and Hepatology, University Medical Center, Utrecht, the Netherlands (BBdM); Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway (SEV); Division of Epidemiology, Norwegian Institute of Public Health, Bergen, Norway (SEV); Bevital AS, Bergen, Norway (ØM); Section for Pharmacology, Department of Clinical Science, University of Bergen, Bergen, Norway (HZ, PMU); Laboratory of Clinical Biochemistry, Haukeland University Hospital, Bergen, Norway (PMU); Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA (VF); Winship Cancer Institute, Emory University, Atlanta, GA (VF); Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway (EW); Department of Research, Cancer Registry of Norway, Oslo, Norway (EW); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (EW); Samfundet Folkhälsan, Helsinki, Finland (EW); Human Genetics Foundation (HuGeF), Torino, Italy (GS, PV); Inserm, Centre for research in Epidemiology and Population Health, U1018, Nutrition, Hormones and Women's Health team, F-94805, Villeju
Stein Emil VollsetDepartment of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrueke, Nuthetal, Germany (KA, HB); Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK (SCC, BBdM, MJG, YL, AJC, ER, PV); Division of Health Policy Translation, Institutes of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan (SCC); Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway (HZ, GST); Molecular Epidemiology Group, Max Delbrueck Center for Molecular Medicine, Berlin-Buch, Germany (TP); International Agency for Research on Cancer, Lyon, France (MJe, SYJK, HF, MJo); National Institute for Public Health and the Environment, Bilthoven, the Netherlands (BBdM); Department of Gastroenterology and Hepatology, University Medical Center, Utrecht, the Netherlands (BBdM); Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway (SEV); Division of Epidemiology, Norwegian Institute of Public Health, Bergen, Norway (SEV); Bevital AS, Bergen, Norway (ØM); Section for Pharmacology, Department of Clinical Science, University of Bergen, Bergen, Norway (HZ, PMU); Laboratory of Clinical Biochemistry, Haukeland University Hospital, Bergen, Norway (PMU); Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA (VF); Winship Cancer Institute, Emory University, Atlanta, GA (VF); Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway (EW); Department of Research, Cancer Registry of Norway, Oslo, Norway (EW); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (EW); Samfundet Folkhälsan, Helsinki, Finland (EW); Human Genetics Foundation (HuGeF), Torino, Italy (GS, PV); Inserm, Centre for research in Epidemiology and Population Health, U1018, Nutrition, Hormones and Women's Health team, F-94805, Villeju
Øivind MidttunDepartment of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrueke, Nuthetal, Germany (KA, HB); Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK (SCC, BBdM, MJG, YL, AJC, ER, PV); Division of Health Policy Translation, Institutes of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan (SCC); Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway (HZ, GST); Molecular Epidemiology Group, Max Delbrueck Center for Molecular Medicine, Berlin-Buch, Germany (TP); International Agency for Research on Cancer, Lyon, France (MJe, SYJK, HF, MJo); National Institute for Public Health and the Environment, Bilthoven, the Netherlands (BBdM); Department of Gastroenterology and Hepatology, University Medical Center, Utrecht, the Netherlands (BBdM); Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway (SEV); Division of Epidemiology, Norwegian Institute of Public Health, Bergen, Norway (SEV); Bevital AS, Bergen, Norway (ØM); Section for Pharmacology, Department of Clinical Science, University of Bergen, Bergen, Norway (HZ, PMU); Laboratory of Clinical Biochemistry, Haukeland University Hospital, Bergen, Norway (PMU); Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA (VF); Winship Cancer Institute, Emory University, Atlanta, GA (VF); Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway (EW); Department of Research, Cancer Registry of Norway, Oslo, Norway (EW); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (EW); Samfundet Folkhälsan, Helsinki, Finland (EW); Human Genetics Foundation (HuGeF), Torino, Italy (GS, PV); Inserm, Centre for research in Epidemiology and Population Health, U1018, Nutrition, Hormones and Women's Health team, F-94805, Villeju
Per Magne UelandDepartment of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrueke, Nuthetal, Germany (KA, HB); Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK (SCC, BBdM, MJG, YL, AJC, ER, PV); Division of Health Policy Translation, Institutes of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan (SCC); Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway (HZ, GST); Molecular Epidemiology Group, Max Delbrueck Center for Molecular Medicine, Berlin-Buch, Germany (TP); International Agency for Research on Cancer, Lyon, France (MJe, SYJK, HF, MJo); National Institute for Public Health and the Environment, Bilthoven, the Netherlands (BBdM); Department of Gastroenterology and Hepatology, University Medical Center, Utrecht, the Netherlands (BBdM); Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway (SEV); Division of Epidemiology, Norwegian Institute of Public Health, Bergen, Norway (SEV); Bevital AS, Bergen, Norway (ØM); Section for Pharmacology, Department of Clinical Science, University of Bergen, Bergen, Norway (HZ, PMU); Laboratory of Clinical Biochemistry, Haukeland University Hospital, Bergen, Norway (PMU); Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA (VF); Winship Cancer Institute, Emory University, Atlanta, GA (VF); Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway (EW); Department of Research, Cancer Registry of Norway, Oslo, Norway (EW); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (EW); Samfundet Folkhälsan, Helsinki, Finland (EW); Human Genetics Foundation (HuGeF), Torino, Italy (GS, PV); Inserm, Centre for research in Epidemiology and Population Health, U1018, Nutrition, Hormones and Women's Health team, F-94805, Villeju
Veronika FedirkoDepartment of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrueke, Nuthetal, Germany (KA, HB); Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK (SCC, BBdM, MJG, YL, AJC, ER, PV); Division of Health Policy Translation, Institutes of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan (SCC); Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway (HZ, GST); Molecular Epidemiology Group, Max Delbrueck Center for Molecular Medicine, Berlin-Buch, Germany (TP); International Agency for Research on Cancer, Lyon, France (MJe, SYJK, HF, MJo); National Institute for Public Health and the Environment, Bilthoven, the Netherlands (BBdM); Department of Gastroenterology and Hepatology, University Medical Center, Utrecht, the Netherlands (BBdM); Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway (SEV); Division of Epidemiology, Norwegian Institute of Public Health, Bergen, Norway (SEV); Bevital AS, Bergen, Norway (ØM); Section for Pharmacology, Department of Clinical Science, University of Bergen, Bergen, Norway (HZ, PMU); Laboratory of Clinical Biochemistry, Haukeland University Hospital, Bergen, Norway (PMU); Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA (VF); Winship Cancer Institute, Emory University, Atlanta, GA (VF); Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway (EW); Department of Research, Cancer Registry of Norway, Oslo, Norway (EW); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (EW); Samfundet Folkhälsan, Helsinki, Finland (EW); Human Genetics Foundation (HuGeF), Torino, Italy (GS, PV); Inserm, Centre for research in Epidemiology and Population Health, U1018, Nutrition, Hormones and Women's Health team, F-94805, Villeju
Mattias JohanssonDepartment of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrueke, Nuthetal, Germany (KA, HB); Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK (SCC, BBdM, MJG, YL, AJC, ER, PV); Division of Health Policy Translation, Institutes of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan (SCC); Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway (HZ, GST); Molecular Epidemiology Group, Max Delbrueck Center for Molecular Medicine, Berlin-Buch, Germany (TP); International Agency for Research on Cancer, Lyon, France (MJe, SYJK, HF, MJo); National Institute for Public Health and the Environment, Bilthoven, the Netherlands (BBdM); Department of Gastroenterology and Hepatology, University Medical Center, Utrecht, the Netherlands (BBdM); Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway (SEV); Division of Epidemiology, Norwegian Institute of Public Health, Bergen, Norway (SEV); Bevital AS, Bergen, Norway (ØM); Section for Pharmacology, Department of Clinical Science, University of Bergen, Bergen, Norway (HZ, PMU); Laboratory of Clinical Biochemistry, Haukeland University Hospital, Bergen, Norway (PMU); Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA (VF); Winship Cancer Institute, Emory University, Atlanta, GA (VF); Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway (EW); Department of Research, Cancer Registry of Norway, Oslo, Norway (EW); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (EW); Samfundet Folkhälsan, Helsinki, Finland (EW); Human Genetics Foundation (HuGeF), Torino, Italy (GS, PV); Inserm, Centre for research in Epidemiology and Population Health, U1018, Nutrition, Hormones and Women's Health team, F-94805, Villeju
Elisabete WeiderpassDepartment of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrueke, Nuthetal, Germany (KA, HB); Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK (SCC, BBdM, MJG, YL, AJC, ER, PV); Division of Health Policy Translation, Institutes of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan (SCC); Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway (HZ, GST); Molecular Epidemiology Group, Max Delbrueck Center for Molecular Medicine, Berlin-Buch, Germany (TP); International Agency for Research on Cancer, Lyon, France (MJe, SYJK, HF, MJo); National Institute for Public Health and the Environment, Bilthoven, the Netherlands (BBdM); Department of Gastroenterology and Hepatology, University Medical Center, Utrecht, the Netherlands (BBdM); Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway (SEV); Division of Epidemiology, Norwegian Institute of Public Health, Bergen, Norway (SEV); Bevital AS, Bergen, Norway (ØM); Section for Pharmacology, Department of Clinical Science, University of Bergen, Bergen, Norway (HZ, PMU); Laboratory of Clinical Biochemistry, Haukeland University Hospital, Bergen, Norway (PMU); Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA (VF); Winship Cancer Institute, Emory University, Atlanta, GA (VF); Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway (EW); Department of Research, Cancer Registry of Norway, Oslo, Norway (EW); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (EW); Samfundet Folkhälsan, Helsinki, Finland (EW); Human Genetics Foundation (HuGeF), Torino, Italy (GS, PV); Inserm, Centre for research in Epidemiology and Population Health, U1018, Nutrition, Hormones and Women's Health team, F-94805, Villeju
Gianluca SeveriDepartment of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrueke, Nuthetal, Germany (KA, HB); Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK (SCC, BBdM, MJG, YL, AJC, ER, PV); Division of Health Policy Translation, Institutes of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan (SCC); Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway (HZ, GST); Molecular Epidemiology Group, Max Delbrueck Center for Molecular Medicine, Berlin-Buch, Germany (TP); International Agency for Research on Cancer, Lyon, France (MJe, SYJK, HF, MJo); National Institute for Public Health and the Environment, Bilthoven, the Netherlands (BBdM); Department of Gastroenterology and Hepatology, University Medical Center, Utrecht, the Netherlands (BBdM); Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway (SEV); Division of Epidemiology, Norwegian Institute of Public Health, Bergen, Norway (SEV); Bevital AS, Bergen, Norway (ØM); Section for Pharmacology, Department of Clinical Science, University of Bergen, Bergen, Norway (HZ, PMU); Laboratory of Clinical Biochemistry, Haukeland University Hospital, Bergen, Norway (PMU); Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA (VF); Winship Cancer Institute, Emory University, Atlanta, GA (VF); Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway (EW); Department of Research, Cancer Registry of Norway, Oslo, Norway (EW); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (EW); Samfundet Folkhälsan, Helsinki, Finland (EW); Human Genetics Foundation (HuGeF), Torino, Italy (GS, PV); Inserm, Centre for research in Epidemiology and Population Health, U1018, Nutrition, Hormones and Women's Health team, F-94805, Villeju
Antoine RacineDepartment of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrueke, Nuthetal, Germany (KA, HB); Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK (SCC, BBdM, MJG, YL, AJC, ER, PV); Division of Health Policy Translation, Institutes of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan (SCC); Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway (HZ, GST); Molecular Epidemiology Group, Max Delbrueck Center for Molecular Medicine, Berlin-Buch, Germany (TP); International Agency for Research on Cancer, Lyon, France (MJe, SYJK, HF, MJo); National Institute for Public Health and the Environment, Bilthoven, the Netherlands (BBdM); Department of Gastroenterology and Hepatology, University Medical Center, Utrecht, the Netherlands (BBdM); Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway (SEV); Division of Epidemiology, Norwegian Institute of Public Health, Bergen, Norway (SEV); Bevital AS, Bergen, Norway (ØM); Section for Pharmacology, Department of Clinical Science, University of Bergen, Bergen, Norway (HZ, PMU); Laboratory of Clinical Biochemistry, Haukeland University Hospital, Bergen, Norway (PMU); Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA (VF); Winship Cancer Institute, Emory University, Atlanta, GA (VF); Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway (EW); Department of Research, Cancer Registry of Norway, Oslo, Norway (EW); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (EW); Samfundet Folkhälsan, Helsinki, Finland (EW); Human Genetics Foundation (HuGeF), Torino, Italy (GS, PV); Inserm, Centre for research in Epidemiology and Population Health, U1018, Nutrition, Hormones and Women's Health team, F-94805, Villeju
Marie-Christine Boutron-RuaultDepartment of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrueke, Nuthetal, Germany (KA, HB); Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK (SCC, BBdM, MJG, YL, AJC, ER, PV); Division of Health Policy Translation, Institutes of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan (SCC); Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway (HZ, GST); Molecular Epidemiology Group, Max Delbrueck Center for Molecular Medicine, Berlin-Buch, Germany (TP); International Agency for Research on Cancer, Lyon, France (MJe, SYJK, HF, MJo); National Institute for Public Health and the Environment, Bilthoven, the Netherlands (BBdM); Department of Gastroenterology and Hepatology, University Medical Center, Utrecht, the Netherlands (BBdM); Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway (SEV); Division of Epidemiology, Norwegian Institute of Public Health, Bergen, Norway (SEV); Bevital AS, Bergen, Norway (ØM); Section for Pharmacology, Department of Clinical Science, University of Bergen, Bergen, Norway (HZ, PMU); Laboratory of Clinical Biochemistry, Haukeland University Hospital, Bergen, Norway (PMU); Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA (VF); Winship Cancer Institute, Emory University, Atlanta, GA (VF); Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway (EW); Department of Research, Cancer Registry of Norway, Oslo, Norway (EW); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (EW); Samfundet Folkhälsan, Helsinki, Finland (EW); Human Genetics Foundation (HuGeF), Torino, Italy (GS, PV); Inserm, Centre for research in Epidemiology and Population Health, U1018, Nutrition, Hormones and Women's Health team, F-94805, Villeju
Rudolf KaaksDepartment of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrueke, Nuthetal, Germany (KA, HB); Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK (SCC, BBdM, MJG, YL, AJC, ER, PV); Division of Health Policy Translation, Institutes of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan (SCC); Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway (HZ, GST); Molecular Epidemiology Group, Max Delbrueck Center for Molecular Medicine, Berlin-Buch, Germany (TP); International Agency for Research on Cancer, Lyon, France (MJe, SYJK, HF, MJo); National Institute for Public Health and the Environment, Bilthoven, the Netherlands (BBdM); Department of Gastroenterology and Hepatology, University Medical Center, Utrecht, the Netherlands (BBdM); Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway (SEV); Division of Epidemiology, Norwegian Institute of Public Health, Bergen, Norway (SEV); Bevital AS, Bergen, Norway (ØM); Section for Pharmacology, Department of Clinical Science, University of Bergen, Bergen, Norway (HZ, PMU); Laboratory of Clinical Biochemistry, Haukeland University Hospital, Bergen, Norway (PMU); Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA (VF); Winship Cancer Institute, Emory University, Atlanta, GA (VF); Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway (EW); Department of Research, Cancer Registry of Norway, Oslo, Norway (EW); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (EW); Samfundet Folkhälsan, Helsinki, Finland (EW); Human Genetics Foundation (HuGeF), Torino, Italy (GS, PV); Inserm, Centre for research in Epidemiology and Population Health, U1018, Nutrition, Hormones and Women's Health team, F-94805, Villeju
Tilman KühnDepartment of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrueke, Nuthetal, Germany (KA, HB); Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK (SCC, BBdM, MJG, YL, AJC, ER, PV); Division of Health Policy Translation, Institutes of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan (SCC); Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway (HZ, GST); Molecular Epidemiology Group, Max Delbrueck Center for Molecular Medicine, Berlin-Buch, Germany (TP); International Agency for Research on Cancer, Lyon, France (MJe, SYJK, HF, MJo); National Institute for Public Health and the Environment, Bilthoven, the Netherlands (BBdM); Department of Gastroenterology and Hepatology, University Medical Center, Utrecht, the Netherlands (BBdM); Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway (SEV); Division of Epidemiology, Norwegian Institute of Public Health, Bergen, Norway (SEV); Bevital AS, Bergen, Norway (ØM); Section for Pharmacology, Department of Clinical Science, University of Bergen, Bergen, Norway (HZ, PMU); Laboratory of Clinical Biochemistry, Haukeland University Hospital, Bergen, Norway (PMU); Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA (VF); Winship Cancer Institute, Emory University, Atlanta, GA (VF); Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway (EW); Department of Research, Cancer Registry of Norway, Oslo, Norway (EW); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (EW); Samfundet Folkhälsan, Helsinki, Finland (EW); Human Genetics Foundation (HuGeF), Torino, Italy (GS, PV); Inserm, Centre for research in Epidemiology and Population Health, U1018, Nutrition, Hormones and Women's Health team, F-94805, Villeju
Anne TjønnelandDepartment of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrueke, Nuthetal, Germany (KA, HB); Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK (SCC, BBdM, MJG, YL, AJC, ER, PV); Division of Health Policy Translation, Institutes of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan (SCC); Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway (HZ, GST); Molecular Epidemiology Group, Max Delbrueck Center for Molecular Medicine, Berlin-Buch, Germany (TP); International Agency for Research on Cancer, Lyon, France (MJe, SYJK, HF, MJo); National Institute for Public Health and the Environment, Bilthoven, the Netherlands (BBdM); Department of Gastroenterology and Hepatology, University Medical Center, Utrecht, the Netherlands (BBdM); Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway (SEV); Division of Epidemiology, Norwegian Institute of Public Health, Bergen, Norway (SEV); Bevital AS, Bergen, Norway (ØM); Section for Pharmacology, Department of Clinical Science, University of Bergen, Bergen, Norway (HZ, PMU); Laboratory of Clinical Biochemistry, Haukeland University Hospital, Bergen, Norway (PMU); Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA (VF); Winship Cancer Institute, Emory University, Atlanta, GA (VF); Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway (EW); Department of Research, Cancer Registry of Norway, Oslo, Norway (EW); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (EW); Samfundet Folkhälsan, Helsinki, Finland (EW); Human Genetics Foundation (HuGeF), Torino, Italy (GS, PV); Inserm, Centre for research in Epidemiology and Population Health, U1018, Nutrition, Hormones and Women's Health team, F-94805, Villeju
Kim OvervadDepartment of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrueke, Nuthetal, Germany (KA, HB); Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK (SCC, BBdM, MJG, YL, AJC, ER, PV); Division of Health Policy Translation, Institutes of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan (SCC); Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway (HZ, GST); Molecular Epidemiology Group, Max Delbrueck Center for Molecular Medicine, Berlin-Buch, Germany (TP); International Agency for Research on Cancer, Lyon, France (MJe, SYJK, HF, MJo); National Institute for Public Health and the Environment, Bilthoven, the Netherlands (BBdM); Department of Gastroenterology and Hepatology, University Medical Center, Utrecht, the Netherlands (BBdM); Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway (SEV); Division of Epidemiology, Norwegian Institute of Public Health, Bergen, Norway (SEV); Bevital AS, Bergen, Norway (ØM); Section for Pharmacology, Department of Clinical Science, University of Bergen, Bergen, Norway (HZ, PMU); Laboratory of Clinical Biochemistry, Haukeland University Hospital, Bergen, Norway (PMU); Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA (VF); Winship Cancer Institute, Emory University, Atlanta, GA (VF); Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway (EW); Department of Research, Cancer Registry of Norway, Oslo, Norway (EW); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (EW); Samfundet Folkhälsan, Helsinki, Finland (EW); Human Genetics Foundation (HuGeF), Torino, Italy (GS, PV); Inserm, Centre for research in Epidemiology and Population Health, U1018, Nutrition, Hormones and Women's Health team, F-94805, Villeju
J Ramón QuirósDepartment of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrueke, Nuthetal, Germany (KA, HB); Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK (SCC, BBdM, MJG, YL, AJC, ER, PV); Division of Health Policy Translation, Institutes of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan (SCC); Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway (HZ, GST); Molecular Epidemiology Group, Max Delbrueck Center for Molecular Medicine, Berlin-Buch, Germany (TP); International Agency for Research on Cancer, Lyon, France (MJe, SYJK, HF, MJo); National Institute for Public Health and the Environment, Bilthoven, the Netherlands (BBdM); Department of Gastroenterology and Hepatology, University Medical Center, Utrecht, the Netherlands (BBdM); Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway (SEV); Division of Epidemiology, Norwegian Institute of Public Health, Bergen, Norway (SEV); Bevital AS, Bergen, Norway (ØM); Section for Pharmacology, Department of Clinical Science, University of Bergen, Bergen, Norway (HZ, PMU); Laboratory of Clinical Biochemistry, Haukeland University Hospital, Bergen, Norway (PMU); Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA (VF); Winship Cancer Institute, Emory University, Atlanta, GA (VF); Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway (EW); Department of Research, Cancer Registry of Norway, Oslo, Norway (EW); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (EW); Samfundet Folkhälsan, Helsinki, Finland (EW); Human Genetics Foundation (HuGeF), Torino, Italy (GS, PV); Inserm, Centre for research in Epidemiology and Population Health, U1018, Nutrition, Hormones and Women's Health team, F-94805, Villeju
Paula JakszynDepartment of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrueke, Nuthetal, Germany (KA, HB); Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK (SCC, BBdM, MJG, YL, AJC, ER, PV); Division of Health Policy Translation, Institutes of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan (SCC); Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway (HZ, GST); Molecular Epidemiology Group, Max Delbrueck Center for Molecular Medicine, Berlin-Buch, Germany (TP); International Agency for Research on Cancer, Lyon, France (MJe, SYJK, HF, MJo); National Institute for Public Health and the Environment, Bilthoven, the Netherlands (BBdM); Department of Gastroenterology and Hepatology, University Medical Center, Utrecht, the Netherlands (BBdM); Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway (SEV); Division of Epidemiology, Norwegian Institute of Public Health, Bergen, Norway (SEV); Bevital AS, Bergen, Norway (ØM); Section for Pharmacology, Department of Clinical Science, University of Bergen, Bergen, Norway (HZ, PMU); Laboratory of Clinical Biochemistry, Haukeland University Hospital, Bergen, Norway (PMU); Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA (VF); Winship Cancer Institute, Emory University, Atlanta, GA (VF); Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway (EW); Department of Research, Cancer Registry of Norway, Oslo, Norway (EW); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (EW); Samfundet Folkhälsan, Helsinki, Finland (EW); Human Genetics Foundation (HuGeF), Torino, Italy (GS, PV); Inserm, Centre for research in Epidemiology and Population Health, U1018, Nutrition, Hormones and Women's Health team, F-94805, Villeju
María-José SánchezDepartment of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrueke, Nuthetal, Germany (KA, HB); Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK (SCC, BBdM, MJG, YL, AJC, ER, PV); Division of Health Policy Translation, Institutes of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan (SCC); Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway (HZ, GST); Molecular Epidemiology Group, Max Delbrueck Center for Molecular Medicine, Berlin-Buch, Germany (TP); International Agency for Research on Cancer, Lyon, France (MJe, SYJK, HF, MJo); National Institute for Public Health and the Environment, Bilthoven, the Netherlands (BBdM); Department of Gastroenterology and Hepatology, University Medical Center, Utrecht, the Netherlands (BBdM); Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway (SEV); Division of Epidemiology, Norwegian Institute of Public Health, Bergen, Norway (SEV); Bevital AS, Bergen, Norway (ØM); Section for Pharmacology, Department of Clinical Science, University of Bergen, Bergen, Norway (HZ, PMU); Laboratory of Clinical Biochemistry, Haukeland University Hospital, Bergen, Norway (PMU); Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA (VF); Winship Cancer Institute, Emory University, Atlanta, GA (VF); Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway (EW); Department of Research, Cancer Registry of Norway, Oslo, Norway (EW); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (EW); Samfundet Folkhälsan, Helsinki, Finland (EW); Human Genetics Foundation (HuGeF), Torino, Italy (GS, PV); Inserm, Centre for research in Epidemiology and Population Health, U1018, Nutrition, Hormones and Women's Health team, F-94805, Villeju
Miren DorronsoroDepartment of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrueke, Nuthetal, Germany (KA, HB); Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK (SCC, BBdM, MJG, YL, AJC, ER, PV); Division of Health Policy Translation, Institutes of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan (SCC); Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway (HZ, GST); Molecular Epidemiology Group, Max Delbrueck Center for Molecular Medicine, Berlin-Buch, Germany (TP); International Agency for Research on Cancer, Lyon, France (MJe, SYJK, HF, MJo); National Institute for Public Health and the Environment, Bilthoven, the Netherlands (BBdM); Department of Gastroenterology and Hepatology, University Medical Center, Utrecht, the Netherlands (BBdM); Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway (SEV); Division of Epidemiology, Norwegian Institute of Public Health, Bergen, Norway (SEV); Bevital AS, Bergen, Norway (ØM); Section for Pharmacology, Department of Clinical Science, University of Bergen, Bergen, Norway (HZ, PMU); Laboratory of Clinical Biochemistry, Haukeland University Hospital, Bergen, Norway (PMU); Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA (VF); Winship Cancer Institute, Emory University, Atlanta, GA (VF); Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway (EW); Department of Research, Cancer Registry of Norway, Oslo, Norway (EW); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (EW); Samfundet Folkhälsan, Helsinki, Finland (EW); Human Genetics Foundation (HuGeF), Torino, Italy (GS, PV); Inserm, Centre for research in Epidemiology and Population Health, U1018, Nutrition, Hormones and Women's Health team, F-94805, Villeju
Maria-Dolores ChirlaqueDepartment of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrueke, Nuthetal, Germany (KA, HB); Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK (SCC, BBdM, MJG, YL, AJC, ER, PV); Division of Health Policy Translation, Institutes of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan (SCC); Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway (HZ, GST); Molecular Epidemiology Group, Max Delbrueck Center for Molecular Medicine, Berlin-Buch, Germany (TP); International Agency for Research on Cancer, Lyon, France (MJe, SYJK, HF, MJo); National Institute for Public Health and the Environment, Bilthoven, the Netherlands (BBdM); Department of Gastroenterology and Hepatology, University Medical Center, Utrecht, the Netherlands (BBdM); Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway (SEV); Division of Epidemiology, Norwegian Institute of Public Health, Bergen, Norway (SEV); Bevital AS, Bergen, Norway (ØM); Section for Pharmacology, Department of Clinical Science, University of Bergen, Bergen, Norway (HZ, PMU); Laboratory of Clinical Biochemistry, Haukeland University Hospital, Bergen, Norway (PMU); Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA (VF); Winship Cancer Institute, Emory University, Atlanta, GA (VF); Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway (EW); Department of Research, Cancer Registry of Norway, Oslo, Norway (EW); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (EW); Samfundet Folkhälsan, Helsinki, Finland (EW); Human Genetics Foundation (HuGeF), Torino, Italy (GS, PV); Inserm, Centre for research in Epidemiology and Population Health, U1018, Nutrition, Hormones and Women's Health team, F-94805, Villeju
Eva ArdanazDepartment of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrueke, Nuthetal, Germany (KA, HB); Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK (SCC, BBdM, MJG, YL, AJC, ER, PV); Division of Health Policy Translation, Institutes of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan (SCC); Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway (HZ, GST); Molecular Epidemiology Group, Max Delbrueck Center for Molecular Medicine, Berlin-Buch, Germany (TP); International Agency for Research on Cancer, Lyon, France (MJe, SYJK, HF, MJo); National Institute for Public Health and the Environment, Bilthoven, the Netherlands (BBdM); Department of Gastroenterology and Hepatology, University Medical Center, Utrecht, the Netherlands (BBdM); Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway (SEV); Division of Epidemiology, Norwegian Institute of Public Health, Bergen, Norway (SEV); Bevital AS, Bergen, Norway (ØM); Section for Pharmacology, Department of Clinical Science, University of Bergen, Bergen, Norway (HZ, PMU); Laboratory of Clinical Biochemistry, Haukeland University Hospital, Bergen, Norway (PMU); Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA (VF); Winship Cancer Institute, Emory University, Atlanta, GA (VF); Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway (EW); Department of Research, Cancer Registry of Norway, Oslo, Norway (EW); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (EW); Samfundet Folkhälsan, Helsinki, Finland (EW); Human Genetics Foundation (HuGeF), Torino, Italy (GS, PV); Inserm, Centre for research in Epidemiology and Population Health, U1018, Nutrition, Hormones and Women's Health team, F-94805, Villeju
Kay-Tee KhawDepartment of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrueke, Nuthetal, Germany (KA, HB); Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK (SCC, BBdM, MJG, YL, AJC, ER, PV); Division of Health Policy Translation, Institutes of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan (SCC); Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway (HZ, GST); Molecular Epidemiology Group, Max Delbrueck Center for Molecular Medicine, Berlin-Buch, Germany (TP); International Agency for Research on Cancer, Lyon, France (MJe, SYJK, HF, MJo); National Institute for Public Health and the Environment, Bilthoven, the Netherlands (BBdM); Department of Gastroenterology and Hepatology, University Medical Center, Utrecht, the Netherlands (BBdM); Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway (SEV); Division of Epidemiology, Norwegian Institute of Public Health, Bergen, Norway (SEV); Bevital AS, Bergen, Norway (ØM); Section for Pharmacology, Department of Clinical Science, University of Bergen, Bergen, Norway (HZ, PMU); Laboratory of Clinical Biochemistry, Haukeland University Hospital, Bergen, Norway (PMU); Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA (VF); Winship Cancer Institute, Emory University, Atlanta, GA (VF); Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway (EW); Department of Research, Cancer Registry of Norway, Oslo, Norway (EW); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (EW); Samfundet Folkhälsan, Helsinki, Finland (EW); Human Genetics Foundation (HuGeF), Torino, Italy (GS, PV); Inserm, Centre for research in Epidemiology and Population Health, U1018, Nutrition, Hormones and Women's Health team, F-94805, Villeju
Nicholas J WarehamDepartment of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrueke, Nuthetal, Germany (KA, HB); Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK (SCC, BBdM, MJG, YL, AJC, ER, PV); Division of Health Policy Translation, Institutes of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan (SCC); Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway (HZ, GST); Molecular Epidemiology Group, Max Delbrueck Center for Molecular Medicine, Berlin-Buch, Germany (TP); International Agency for Research on Cancer, Lyon, France (MJe, SYJK, HF, MJo); National Institute for Public Health and the Environment, Bilthoven, the Netherlands (BBdM); Department of Gastroenterology and Hepatology, University Medical Center, Utrecht, the Netherlands (BBdM); Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway (SEV); Division of Epidemiology, Norwegian Institute of Public Health, Bergen, Norway (SEV); Bevital AS, Bergen, Norway (ØM); Section for Pharmacology, Department of Clinical Science, University of Bergen, Bergen, Norway (HZ, PMU); Laboratory of Clinical Biochemistry, Haukeland University Hospital, Bergen, Norway (PMU); Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA (VF); Winship Cancer Institute, Emory University, Atlanta, GA (VF); Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway (EW); Department of Research, Cancer Registry of Norway, Oslo, Norway (EW); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (EW); Samfundet Folkhälsan, Helsinki, Finland (EW); Human Genetics Foundation (HuGeF), Torino, Italy (GS, PV); Inserm, Centre for research in Epidemiology and Population Health, U1018, Nutrition, Hormones and Women's Health team, F-94805, Villeju
Ruth C TravisDepartment of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrueke, Nuthetal, Germany (KA, HB); Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK (SCC, BBdM, MJG, YL, AJC, ER, PV); Division of Health Policy Translation, Institutes of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan (SCC); Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway (HZ, GST); Molecular Epidemiology Group, Max Delbrueck Center for Molecular Medicine, Berlin-Buch, Germany (TP); International Agency for Research on Cancer, Lyon, France (MJe, SYJK, HF, MJo); National Institute for Public Health and the Environment, Bilthoven, the Netherlands (BBdM); Department of Gastroenterology and Hepatology, University Medical Center, Utrecht, the Netherlands (BBdM); Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway (SEV); Division of Epidemiology, Norwegian Institute of Public Health, Bergen, Norway (SEV); Bevital AS, Bergen, Norway (ØM); Section for Pharmacology, Department of Clinical Science, University of Bergen, Bergen, Norway (HZ, PMU); Laboratory of Clinical Biochemistry, Haukeland University Hospital, Bergen, Norway (PMU); Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA (VF); Winship Cancer Institute, Emory University, Atlanta, GA (VF); Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway (EW); Department of Research, Cancer Registry of Norway, Oslo, Norway (EW); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (EW); Samfundet Folkhälsan, Helsinki, Finland (EW); Human Genetics Foundation (HuGeF), Torino, Italy (GS, PV); Inserm, Centre for research in Epidemiology and Population Health, U1018, Nutrition, Hormones and Women's Health team, F-94805, Villeju
Antonia TrichopoulouDepartment of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrueke, Nuthetal, Germany (KA, HB); Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK (SCC, BBdM, MJG, YL, AJC, ER, PV); Division of Health Policy Translation, Institutes of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan (SCC); Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway (HZ, GST); Molecular Epidemiology Group, Max Delbrueck Center for Molecular Medicine, Berlin-Buch, Germany (TP); International Agency for Research on Cancer, Lyon, France (MJe, SYJK, HF, MJo); National Institute for Public Health and the Environment, Bilthoven, the Netherlands (BBdM); Department of Gastroenterology and Hepatology, University Medical Center, Utrecht, the Netherlands (BBdM); Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway (SEV); Division of Epidemiology, Norwegian Institute of Public Health, Bergen, Norway (SEV); Bevital AS, Bergen, Norway (ØM); Section for Pharmacology, Department of Clinical Science, University of Bergen, Bergen, Norway (HZ, PMU); Laboratory of Clinical Biochemistry, Haukeland University Hospital, Bergen, Norway (PMU); Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA (VF); Winship Cancer Institute, Emory University, Atlanta, GA (VF); Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway (EW); Department of Research, Cancer Registry of Norway, Oslo, Norway (EW); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (EW); Samfundet Folkhälsan, Helsinki, Finland (EW); Human Genetics Foundation (HuGeF), Torino, Italy (GS, PV); Inserm, Centre for research in Epidemiology and Population Health, U1018, Nutrition, Hormones and Women's Health team, F-94805, Villeju
Pagona LagiouDepartment of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrueke, Nuthetal, Germany (KA, HB); Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK (SCC, BBdM, MJG, YL, AJC, ER, PV); Division of Health Policy Translation, Institutes of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan (SCC); Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway (HZ, GST); Molecular Epidemiology Group, Max Delbrueck Center for Molecular Medicine, Berlin-Buch, Germany (TP); International Agency for Research on Cancer, Lyon, France (MJe, SYJK, HF, MJo); National Institute for Public Health and the Environment, Bilthoven, the Netherlands (BBdM); Department of Gastroenterology and Hepatology, University Medical Center, Utrecht, the Netherlands (BBdM); Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway (SEV); Division of Epidemiology, Norwegian Institute of Public Health, Bergen, Norway (SEV); Bevital AS, Bergen, Norway (ØM); Section for Pharmacology, Department of Clinical Science, University of Bergen, Bergen, Norway (HZ, PMU); Laboratory of Clinical Biochemistry, Haukeland University Hospital, Bergen, Norway (PMU); Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA (VF); Winship Cancer Institute, Emory University, Atlanta, GA (VF); Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway (EW); Department of Research, Cancer Registry of Norway, Oslo, Norway (EW); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (EW); Samfundet Folkhälsan, Helsinki, Finland (EW); Human Genetics Foundation (HuGeF), Torino, Italy (GS, PV); Inserm, Centre for research in Epidemiology and Population Health, U1018, Nutrition, Hormones and Women's Health team, F-94805, Villeju
Dimitrios TrichopoulosDepartment of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrueke, Nuthetal, Germany (KA, HB); Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK (SCC, BBdM, MJG, YL, AJC, ER, PV); Division of Health Policy Translation, Institutes of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan (SCC); Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway (HZ, GST); Molecular Epidemiology Group, Max Delbrueck Center for Molecular Medicine, Berlin-Buch, Germany (TP); International Agency for Research on Cancer, Lyon, France (MJe, SYJK, HF, MJo); National Institute for Public Health and the Environment, Bilthoven, the Netherlands (BBdM); Department of Gastroenterology and Hepatology, University Medical Center, Utrecht, the Netherlands (BBdM); Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway (SEV); Division of Epidemiology, Norwegian Institute of Public Health, Bergen, Norway (SEV); Bevital AS, Bergen, Norway (ØM); Section for Pharmacology, Department of Clinical Science, University of Bergen, Bergen, Norway (HZ, PMU); Laboratory of Clinical Biochemistry, Haukeland University Hospital, Bergen, Norway (PMU); Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA (VF); Winship Cancer Institute, Emory University, Atlanta, GA (VF); Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway (EW); Department of Research, Cancer Registry of Norway, Oslo, Norway (EW); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (EW); Samfundet Folkhälsan, Helsinki, Finland (EW); Human Genetics Foundation (HuGeF), Torino, Italy (GS, PV); Inserm, Centre for research in Epidemiology and Population Health, U1018, Nutrition, Hormones and Women's Health team, F-94805, Villeju
Domenico PalliDepartment of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrueke, Nuthetal, Germany (KA, HB); Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK (SCC, BBdM, MJG, YL, AJC, ER, PV); Division of Health Policy Translation, Institutes of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan (SCC); Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway (HZ, GST); Molecular Epidemiology Group, Max Delbrueck Center for Molecular Medicine, Berlin-Buch, Germany (TP); International Agency for Research on Cancer, Lyon, France (MJe, SYJK, HF, MJo); National Institute for Public Health and the Environment, Bilthoven, the Netherlands (BBdM); Department of Gastroenterology and Hepatology, University Medical Center, Utrecht, the Netherlands (BBdM); Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway (SEV); Division of Epidemiology, Norwegian Institute of Public Health, Bergen, Norway (SEV); Bevital AS, Bergen, Norway (ØM); Section for Pharmacology, Department of Clinical Science, University of Bergen, Bergen, Norway (HZ, PMU); Laboratory of Clinical Biochemistry, Haukeland University Hospital, Bergen, Norway (PMU); Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA (VF); Winship Cancer Institute, Emory University, Atlanta, GA (VF); Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway (EW); Department of Research, Cancer Registry of Norway, Oslo, Norway (EW); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (EW); Samfundet Folkhälsan, Helsinki, Finland (EW); Human Genetics Foundation (HuGeF), Torino, Italy (GS, PV); Inserm, Centre for research in Epidemiology and Population Health, U1018, Nutrition, Hormones and Women's Health team, F-94805, Villeju
Sabina SieriDepartment of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrueke, Nuthetal, Germany (KA, HB); Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK (SCC, BBdM, MJG, YL, AJC, ER, PV); Division of Health Policy Translation, Institutes of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan (SCC); Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway (HZ, GST); Molecular Epidemiology Group, Max Delbrueck Center for Molecular Medicine, Berlin-Buch, Germany (TP); International Agency for Research on Cancer, Lyon, France (MJe, SYJK, HF, MJo); National Institute for Public Health and the Environment, Bilthoven, the Netherlands (BBdM); Department of Gastroenterology and Hepatology, University Medical Center, Utrecht, the Netherlands (BBdM); Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway (SEV); Division of Epidemiology, Norwegian Institute of Public Health, Bergen, Norway (SEV); Bevital AS, Bergen, Norway (ØM); Section for Pharmacology, Department of Clinical Science, University of Bergen, Bergen, Norway (HZ, PMU); Laboratory of Clinical Biochemistry, Haukeland University Hospital, Bergen, Norway (PMU); Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA (VF); Winship Cancer Institute, Emory University, Atlanta, GA (VF); Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway (EW); Department of Research, Cancer Registry of Norway, Oslo, Norway (EW); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (EW); Samfundet Folkhälsan, Helsinki, Finland (EW); Human Genetics Foundation (HuGeF), Torino, Italy (GS, PV); Inserm, Centre for research in Epidemiology and Population Health, U1018, Nutrition, Hormones and Women's Health team, F-94805, Villeju
Rosario TuminoDepartment of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrueke, Nuthetal, Germany (KA, HB); Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK (SCC, BBdM, MJG, YL, AJC, ER, PV); Division of Health Policy Translation, Institutes of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan (SCC); Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway (HZ, GST); Molecular Epidemiology Group, Max Delbrueck Center for Molecular Medicine, Berlin-Buch, Germany (TP); International Agency for Research on Cancer, Lyon, France (MJe, SYJK, HF, MJo); National Institute for Public Health and the Environment, Bilthoven, the Netherlands (BBdM); Department of Gastroenterology and Hepatology, University Medical Center, Utrecht, the Netherlands (BBdM); Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway (SEV); Division of Epidemiology, Norwegian Institute of Public Health, Bergen, Norway (SEV); Bevital AS, Bergen, Norway (ØM); Section for Pharmacology, Department of Clinical Science, University of Bergen, Bergen, Norway (HZ, PMU); Laboratory of Clinical Biochemistry, Haukeland University Hospital, Bergen, Norway (PMU); Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA (VF); Winship Cancer Institute, Emory University, Atlanta, GA (VF); Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway (EW); Department of Research, Cancer Registry of Norway, Oslo, Norway (EW); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (EW); Samfundet Folkhälsan, Helsinki, Finland (EW); Human Genetics Foundation (HuGeF), Torino, Italy (GS, PV); Inserm, Centre for research in Epidemiology and Population Health, U1018, Nutrition, Hormones and Women's Health team, F-94805, Villeju
Salvatore PanicoDepartment of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrueke, Nuthetal, Germany (KA, HB); Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK (SCC, BBdM, MJG, YL, AJC, ER, PV); Division of Health Policy Translation, Institutes of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan (SCC); Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway (HZ, GST); Molecular Epidemiology Group, Max Delbrueck Center for Molecular Medicine, Berlin-Buch, Germany (TP); International Agency for Research on Cancer, Lyon, France (MJe, SYJK, HF, MJo); National Institute for Public Health and the Environment, Bilthoven, the Netherlands (BBdM); Department of Gastroenterology and Hepatology, University Medical Center, Utrecht, the Netherlands (BBdM); Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway (SEV); Division of Epidemiology, Norwegian Institute of Public Health, Bergen, Norway (SEV); Bevital AS, Bergen, Norway (ØM); Section for Pharmacology, Department of Clinical Science, University of Bergen, Bergen, Norway (HZ, PMU); Laboratory of Clinical Biochemistry, Haukeland University Hospital, Bergen, Norway (PMU); Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA (VF); Winship Cancer Institute, Emory University, Atlanta, GA (VF); Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway (EW); Department of Research, Cancer Registry of Norway, Oslo, Norway (EW); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (EW); Samfundet Folkhälsan, Helsinki, Finland (EW); Human Genetics Foundation (HuGeF), Torino, Italy (GS, PV); Inserm, Centre for research in Epidemiology and Population Health, U1018, Nutrition, Hormones and Women's Health team, F-94805, Villeju
Anne M MayDepartment of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrueke, Nuthetal, Germany (KA, HB); Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK (SCC, BBdM, MJG, YL, AJC, ER, PV); Division of Health Policy Translation, Institutes of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan (SCC); Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway (HZ, GST); Molecular Epidemiology Group, Max Delbrueck Center for Molecular Medicine, Berlin-Buch, Germany (TP); International Agency for Research on Cancer, Lyon, France (MJe, SYJK, HF, MJo); National Institute for Public Health and the Environment, Bilthoven, the Netherlands (BBdM); Department of Gastroenterology and Hepatology, University Medical Center, Utrecht, the Netherlands (BBdM); Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway (SEV); Division of Epidemiology, Norwegian Institute of Public Health, Bergen, Norway (SEV); Bevital AS, Bergen, Norway (ØM); Section for Pharmacology, Department of Clinical Science, University of Bergen, Bergen, Norway (HZ, PMU); Laboratory of Clinical Biochemistry, Haukeland University Hospital, Bergen, Norway (PMU); Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA (VF); Winship Cancer Institute, Emory University, Atlanta, GA (VF); Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway (EW); Department of Research, Cancer Registry of Norway, Oslo, Norway (EW); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (EW); Samfundet Folkhälsan, Helsinki, Finland (EW); Human Genetics Foundation (HuGeF), Torino, Italy (GS, PV); Inserm, Centre for research in Epidemiology and Population Health, U1018, Nutrition, Hormones and Women's Health team, F-94805, Villeju
Richard PalmqvistDepartment of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrueke, Nuthetal, Germany (KA, HB); Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK (SCC, BBdM, MJG, YL, AJC, ER, PV); Division of Health Policy Translation, Institutes of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan (SCC); Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway (HZ, GST); Molecular Epidemiology Group, Max Delbrueck Center for Molecular Medicine, Berlin-Buch, Germany (TP); International Agency for Research on Cancer, Lyon, France (MJe, SYJK, HF, MJo); National Institute for Public Health and the Environment, Bilthoven, the Netherlands (BBdM); Department of Gastroenterology and Hepatology, University Medical Center, Utrecht, the Netherlands (BBdM); Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway (SEV); Division of Epidemiology, Norwegian Institute of Public Health, Bergen, Norway (SEV); Bevital AS, Bergen, Norway (ØM); Section for Pharmacology, Department of Clinical Science, University of Bergen, Bergen, Norway (HZ, PMU); Laboratory of Clinical Biochemistry, Haukeland University Hospital, Bergen, Norway (PMU); Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA (VF); Winship Cancer Institute, Emory University, Atlanta, GA (VF); Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway (EW); Department of Research, Cancer Registry of Norway, Oslo, Norway (EW); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (EW); Samfundet Folkhälsan, Helsinki, Finland (EW); Human Genetics Foundation (HuGeF), Torino, Italy (GS, PV); Inserm, Centre for research in Epidemiology and Population Health, U1018, Nutrition, Hormones and Women's Health team, F-94805, Villeju
Ingrid LjuslinderDepartment of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrueke, Nuthetal, Germany (KA, HB); Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK (SCC, BBdM, MJG, YL, AJC, ER, PV); Division of Health Policy Translation, Institutes of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan (SCC); Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway (HZ, GST); Molecular Epidemiology Group, Max Delbrueck Center for Molecular Medicine, Berlin-Buch, Germany (TP); International Agency for Research on Cancer, Lyon, France (MJe, SYJK, HF, MJo); National Institute for Public Health and the Environment, Bilthoven, the Netherlands (BBdM); Department of Gastroenterology and Hepatology, University Medical Center, Utrecht, the Netherlands (BBdM); Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway (SEV); Division of Epidemiology, Norwegian Institute of Public Health, Bergen, Norway (SEV); Bevital AS, Bergen, Norway (ØM); Section for Pharmacology, Department of Clinical Science, University of Bergen, Bergen, Norway (HZ, PMU); Laboratory of Clinical Biochemistry, Haukeland University Hospital, Bergen, Norway (PMU); Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA (VF); Winship Cancer Institute, Emory University, Atlanta, GA (VF); Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway (EW); Department of Research, Cancer Registry of Norway, Oslo, Norway (EW); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (EW); Samfundet Folkhälsan, Helsinki, Finland (EW); Human Genetics Foundation (HuGeF), Torino, Italy (GS, PV); Inserm, Centre for research in Epidemiology and Population Health, U1018, Nutrition, Hormones and Women's Health team, F-94805, Villeju
So Yeon J KongDepartment of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrueke, Nuthetal, Germany (KA, HB); Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK (SCC, BBdM, MJG, YL, AJC, ER, PV); Division of Health Policy Translation, Institutes of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan (SCC); Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway (HZ, GST); Molecular Epidemiology Group, Max Delbrueck Center for Molecular Medicine, Berlin-Buch, Germany (TP); International Agency for Research on Cancer, Lyon, France (MJe, SYJK, HF, MJo); National Institute for Public Health and the Environment, Bilthoven, the Netherlands (BBdM); Department of Gastroenterology and Hepatology, University Medical Center, Utrecht, the Netherlands (BBdM); Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway (SEV); Division of Epidemiology, Norwegian Institute of Public Health, Bergen, Norway (SEV); Bevital AS, Bergen, Norway (ØM); Section for Pharmacology, Department of Clinical Science, University of Bergen, Bergen, Norway (HZ, PMU); Laboratory of Clinical Biochemistry, Haukeland University Hospital, Bergen, Norway (PMU); Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA (VF); Winship Cancer Institute, Emory University, Atlanta, GA (VF); Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway (EW); Department of Research, Cancer Registry of Norway, Oslo, Norway (EW); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (EW); Samfundet Folkhälsan, Helsinki, Finland (EW); Human Genetics Foundation (HuGeF), Torino, Italy (GS, PV); Inserm, Centre for research in Epidemiology and Population Health, U1018, Nutrition, Hormones and Women's Health team, F-94805, Villeju
Heinz FreislingDepartment of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrueke, Nuthetal, Germany (KA, HB); Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK (SCC, BBdM, MJG, YL, AJC, ER, PV); Division of Health Policy Translation, Institutes of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan (SCC); Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway (HZ, GST); Molecular Epidemiology Group, Max Delbrueck Center for Molecular Medicine, Berlin-Buch, Germany (TP); International Agency for Research on Cancer, Lyon, France (MJe, SYJK, HF, MJo); National Institute for Public Health and the Environment, Bilthoven, the Netherlands (BBdM); Department of Gastroenterology and Hepatology, University Medical Center, Utrecht, the Netherlands (BBdM); Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway (SEV); Division of Epidemiology, Norwegian Institute of Public Health, Bergen, Norway (SEV); Bevital AS, Bergen, Norway (ØM); Section for Pharmacology, Department of Clinical Science, University of Bergen, Bergen, Norway (HZ, PMU); Laboratory of Clinical Biochemistry, Haukeland University Hospital, Bergen, Norway (PMU); Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA (VF); Winship Cancer Institute, Emory University, Atlanta, GA (VF); Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway (EW); Department of Research, Cancer Registry of Norway, Oslo, Norway (EW); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (EW); Samfundet Folkhälsan, Helsinki, Finland (EW); Human Genetics Foundation (HuGeF), Torino, Italy (GS, PV); Inserm, Centre for research in Epidemiology and Population Health, U1018, Nutrition, Hormones and Women's Health team, F-94805, Villeju
Marc J GunterDepartment of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrueke, Nuthetal, Germany (KA, HB); Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK (SCC, BBdM, MJG, YL, AJC, ER, PV); Division of Health Policy Translation, Institutes of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan (SCC); Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway (HZ, GST); Molecular Epidemiology Group, Max Delbrueck Center for Molecular Medicine, Berlin-Buch, Germany (TP); International Agency for Research on Cancer, Lyon, France (MJe, SYJK, HF, MJo); National Institute for Public Health and the Environment, Bilthoven, the Netherlands (BBdM); Department of Gastroenterology and Hepatology, University Medical Center, Utrecht, the Netherlands (BBdM); Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway (SEV); Division of Epidemiology, Norwegian Institute of Public Health, Bergen, Norway (SEV); Bevital AS, Bergen, Norway (ØM); Section for Pharmacology, Department of Clinical Science, University of Bergen, Bergen, Norway (HZ, PMU); Laboratory of Clinical Biochemistry, Haukeland University Hospital, Bergen, Norway (PMU); Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA (VF); Winship Cancer Institute, Emory University, Atlanta, GA (VF); Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway (EW); Department of Research, Cancer Registry of Norway, Oslo, Norway (EW); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (EW); Samfundet Folkhälsan, Helsinki, Finland (EW); Human Genetics Foundation (HuGeF), Torino, Italy (GS, PV); Inserm, Centre for research in Epidemiology and Population Health, U1018, Nutrition, Hormones and Women's Health team, F-94805, Villeju
Yunxia LuDepartment of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrueke, Nuthetal, Germany (KA, HB); Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK (SCC, BBdM, MJG, YL, AJC, ER, PV); Division of Health Policy Translation, Institutes of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan (SCC); Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway (HZ, GST); Molecular Epidemiology Group, Max Delbrueck Center for Molecular Medicine, Berlin-Buch, Germany (TP); International Agency for Research on Cancer, Lyon, France (MJe, SYJK, HF, MJo); National Institute for Public Health and the Environment, Bilthoven, the Netherlands (BBdM); Department of Gastroenterology and Hepatology, University Medical Center, Utrecht, the Netherlands (BBdM); Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway (SEV); Division of Epidemiology, Norwegian Institute of Public Health, Bergen, Norway (SEV); Bevital AS, Bergen, Norway (ØM); Section for Pharmacology, Department of Clinical Science, University of Bergen, Bergen, Norway (HZ, PMU); Laboratory of Clinical Biochemistry, Haukeland University Hospital, Bergen, Norway (PMU); Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA (VF); Winship Cancer Institute, Emory University, Atlanta, GA (VF); Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway (EW); Department of Research, Cancer Registry of Norway, Oslo, Norway (EW); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (EW); Samfundet Folkhälsan, Helsinki, Finland (EW); Human Genetics Foundation (HuGeF), Torino, Italy (GS, PV); Inserm, Centre for research in Epidemiology and Population Health, U1018, Nutrition, Hormones and Women's Health team, F-94805, Villeju
Amanda J CrossDepartment of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrueke, Nuthetal, Germany (KA, HB); Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK (SCC, BBdM, MJG, YL, AJC, ER, PV); Division of Health Policy Translation, Institutes of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan (SCC); Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway (HZ, GST); Molecular Epidemiology Group, Max Delbrueck Center for Molecular Medicine, Berlin-Buch, Germany (TP); International Agency for Research on Cancer, Lyon, France (MJe, SYJK, HF, MJo); National Institute for Public Health and the Environment, Bilthoven, the Netherlands (BBdM); Department of Gastroenterology and Hepatology, University Medical Center, Utrecht, the Netherlands (BBdM); Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway (SEV); Division of Epidemiology, Norwegian Institute of Public Health, Bergen, Norway (SEV); Bevital AS, Bergen, Norway (ØM); Section for Pharmacology, Department of Clinical Science, University of Bergen, Bergen, Norway (HZ, PMU); Laboratory of Clinical Biochemistry, Haukeland University Hospital, Bergen, Norway (PMU); Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA (VF); Winship Cancer Institute, Emory University, Atlanta, GA (VF); Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway (EW); Department of Research, Cancer Registry of Norway, Oslo, Norway (EW); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (EW); Samfundet Folkhälsan, Helsinki, Finland (EW); Human Genetics Foundation (HuGeF), Torino, Italy (GS, PV); Inserm, Centre for research in Epidemiology and Population Health, U1018, Nutrition, Hormones and Women's Health team, F-94805, Villeju
Elio RiboliDepartment of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrueke, Nuthetal, Germany (KA, HB); Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK (SCC, BBdM, MJG, YL, AJC, ER, PV); Division of Health Policy Translation, Institutes of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan (SCC); Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway (HZ, GST); Molecular Epidemiology Group, Max Delbrueck Center for Molecular Medicine, Berlin-Buch, Germany (TP); International Agency for Research on Cancer, Lyon, France (MJe, SYJK, HF, MJo); National Institute for Public Health and the Environment, Bilthoven, the Netherlands (BBdM); Department of Gastroenterology and Hepatology, University Medical Center, Utrecht, the Netherlands (BBdM); Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway (SEV); Division of Epidemiology, Norwegian Institute of Public Health, Bergen, Norway (SEV); Bevital AS, Bergen, Norway (ØM); Section for Pharmacology, Department of Clinical Science, University of Bergen, Bergen, Norway (HZ, PMU); Laboratory of Clinical Biochemistry, Haukeland University Hospital, Bergen, Norway (PMU); Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA (VF); Winship Cancer Institute, Emory University, Atlanta, GA (VF); Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway (EW); Department of Research, Cancer Registry of Norway, Oslo, Norway (EW); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (EW); Samfundet Folkhälsan, Helsinki, Finland (EW); Human Genetics Foundation (HuGeF), Torino, Italy (GS, PV); Inserm, Centre for research in Epidemiology and Population Health, U1018, Nutrition, Hormones and Women's Health team, F-94805, Villeju
Paolo VineisDepartment of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrueke, Nuthetal, Germany (KA, HB); Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK (SCC, BBdM, MJG, YL, AJC, ER, PV); Division of Health Policy Translation, Institutes of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan (SCC); Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway (HZ, GST); Molecular Epidemiology Group, Max Delbrueck Center for Molecular Medicine, Berlin-Buch, Germany (TP); International Agency for Research on Cancer, Lyon, France (MJe, SYJK, HF, MJo); National Institute for Public Health and the Environment, Bilthoven, the Netherlands (BBdM); Department of Gastroenterology and Hepatology, University Medical Center, Utrecht, the Netherlands (BBdM); Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway (SEV); Division of Epidemiology, Norwegian Institute of Public Health, Bergen, Norway (SEV); Bevital AS, Bergen, Norway (ØM); Section for Pharmacology, Department of Clinical Science, University of Bergen, Bergen, Norway (HZ, PMU); Laboratory of Clinical Biochemistry, Haukeland University Hospital, Bergen, Norway (PMU); Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA (VF); Winship Cancer Institute, Emory University, Atlanta, GA (VF); Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway (EW); Department of Research, Cancer Registry of Norway, Oslo, Norway (EW); Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (EW); Samfundet Folkhälsan, Helsinki, Finland (EW); Human Genetics Foundation (HuGeF), Torino, Italy (GS, PV); Inserm, Centre for research in Epidemiology and Population Health, U1018, Nutrition, Hormones and Women's Health team, F-94805, Villeju
Haukeland University Hospital · NOUniversity of Bergen · NOGerman Institute of Human Nutrition · DEInserm · FRNational Health Research Institutes · TWCancer Registry of Norway · NONorwegian Institute of Public Health · NOImperial College London · GB
Funding
Lifestyle, insulin, IGF-I and colorectal cancerR01CA102460 · NCI · INTERNATIONAL AGENCY FOR RES ON CANCER · PI KAAKS, RUDOLF J · 2003 to 2005
$408kCancer Research UK 16491Medical Research Council G0401527Medical Research Council G1000143Medical Research Council MC_U106179471Medical Research Council MC_UU_12015/1NCI NIH HHS 1R01CA102460World Health Organization 001
Abstract
backgroundNeopterin may be relevant for colorectal cancer (CRC) development, as a biomarker of cellular immune activity exerting pleiotropic effects on cellular ageing, oxidative stress, and inflammation. So far, the association between prediagnostic neopterin and colon and rectal cancer risk has not been evaluated in human populations.
methodsA nested case-control study was conducted within the European Prospective Investigation into Cancer and Nutrition cohort using data on plasma concentrations of total neopterin (T-N, sum of neopterin and 7,8-dihydroneopterin) in 830 incident CRC case patients (561 colon and 269 rectal) matched within risk sets to 830 control participants. A subsequent replication study used data from the Hordaland Health Study, where 173 CRC case patients have been diagnosed among 6594 healthy participants over 12 years of follow-up.
resultsAfter multivariable adjustment for a priori chosen CRC risk factors, a "U-shaped" association of T-N with CRC was revealed. Compared with the second quintile of the T-N distribution, the relative risks for the first, third, fourth, and fifth quintiles were 2.37 (95% CI = 1.66 to 3.39), 1.24 (95% CI = 0.87 to 1.77), 1.55 (95% CI = 1.08 to 2.22), and 2.31 (95% CI = 1.63 to 3.27), respectively. Replication of these associations within the Hordaland Health Study yielded similar results. No differences have been observed when the associations were explored by colon and rectal cancer site (two-sided P difference = .87) and after excluding case patients diagnosed within the first four follow-up years.
conclusionsThese novel findings provide evidence of the role of both suppressed and activated cell-mediated immunity as reflected by prediagnostic T-N concentrations in the development of CRC.
Indexed as
Immunity, CellularAdultAgedBiomarkers, TumorCase-Control StudiesChromatography, LiquidColonic NeoplasmsColorectal NeoplasmsEuropeFemaleHumansMaleMiddle AgedNeopterinOdds RatioProspective Studies7,8-dihydroneopterinBiomarkers, TumorNeopterin
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.