Evidence map›Paper›PMID 25713001›Full record

SynthesisNeurology2015

Resting brain activity in disorders of consciousness: a systematic review and meta-analysis.

Yousef Hannawi, Martin A Lindquist, Brian S Caffo, Haris I Sair, Robert D Stevens

Erratum issuedAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 82 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
82citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

82 citing papers in PubMed, 7 syntheses or guidelines pooled it.

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22 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Yousef HannawiFrom the Departments of Anesthesiology and Critical Care Medicine (Y.H., R.D.S.), Neurology (Y.H., R.D.S.), Radiology (H.I.S., R.D.S.), and Neurosurgery (R.D.S.), Johns Hopkins University School of Medicine, Baltimore; and Department of Biostatistics (M.A.L., B.S.C.), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD. yousefhannawi@yahoo.com.
Martin A LindquistFrom the Departments of Anesthesiology and Critical Care Medicine (Y.H., R.D.S.), Neurology (Y.H., R.D.S.), Radiology (H.I.S., R.D.S.), and Neurosurgery (R.D.S.), Johns Hopkins University School of Medicine, Baltimore; and Department of Biostatistics (M.A.L., B.S.C.), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.
Brian S CaffoFrom the Departments of Anesthesiology and Critical Care Medicine (Y.H., R.D.S.), Neurology (Y.H., R.D.S.), Radiology (H.I.S., R.D.S.), and Neurosurgery (R.D.S.), Johns Hopkins University School of Medicine, Baltimore; and Department of Biostatistics (M.A.L., B.S.C.), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.
Haris I SairFrom the Departments of Anesthesiology and Critical Care Medicine (Y.H., R.D.S.), Neurology (Y.H., R.D.S.), Radiology (H.I.S., R.D.S.), and Neurosurgery (R.D.S.), Johns Hopkins University School of Medicine, Baltimore; and Department of Biostatistics (M.A.L., B.S.C.), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.
Robert D StevensFrom the Departments of Anesthesiology and Critical Care Medicine (Y.H., R.D.S.), Neurology (Y.H., R.D.S.), Radiology (H.I.S., R.D.S.), and Neurosurgery (R.D.S.), Johns Hopkins University School of Medicine, Baltimore; and Department of Biostatistics (M.A.L., B.S.C.), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.

Funding

Statistical methods for large n and p problemsR01EB012547 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI CAFFO, BRIAN SCOTT · 2010 to 2016
$2.1M
NIBIB NIH HHS R01 EB012547
6 · The paper itself

Abstract

objectiveTo quantitatively synthesize results from neuroimaging studies that evaluated patterns of resting functional activity in patients with disorders of consciousness (DOC).

methodsWe performed a systematic review and coordinate-based meta-analysis of studies published up to May 2014. Studies were included if they compared resting-state functional neuroimaging data acquired in patients with DOC (coma, minimally conscious state, emergence from minimally conscious state, or vegetative state) with a group of healthy controls. Coordinate-based meta-analysis was performed in studies that included voxel-based comparisons at the whole-brain level and if analysis was accomplished with data-driven approaches.

resultsA total of 36 studies (687 patients, 637 healthy controls) were included in the systematic review. Reported DOC were vegetative state (43.2%), coma (23.4%), minimally conscious state (22.8%), and emergence from minimally conscious state (1.6%); the most common etiologies of DOC were traumatic brain injury (37.7%) and anoxic brain injury (36.9%). Functional neuroimaging was accomplished using fMRI (16 studies), PET (15 studies), SPECT (4 studies), and both PET and SPECT in one study. Meta-analysis in 13 studies (272 patients, 259 healthy controls) revealed consistently reduced activity in patients with DOC in bilateral medial dorsal nucleus of the thalamus, left cingulate, posterior cingulate, precuneus, and middle frontal and medial temporal gyri.

conclusionsIn patients with DOC evaluated in the resting state, functional neuroimaging indicates markedly reduced activity within midline cortical and subcortical sites, anatomical structures that have been linked to the default-mode network. Studies are needed to determine the relation between activation (and coherence) within these structures and the emergence of conscious awareness.

Indexed as

Functional NeuroimagingBrainConsciousness DisordersHumans

Identifiers

PMID25713001
PMCPMC4366089

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.