ArticleThe Journal of infectious diseases2015
Novel Insights Into the Protective Role of Hemoglobin S and C Against Plasmodium falciparum Parasitemia.
Article in The Journal of infectious diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 36 citations in OpenAlex.
- Sickle cell haemoglobin status shapes malaria parasite genotype in asymptomatic infections.Nature microbiology · 2026Article
- More than malaria: ExploringCurrent research in parasitology & vector-borne diseases · 2026Review
- Human genetic variations conferring resistance to malaria.Journal of translational medicine · 2025Review
- Urogenital Schistosomiasis Is Associated with an Increased Risk of Plasmodium falciparum Infection in Burkina Faso.The American journal of tropical medicine and hygiene · 2025Article
- Influence of genetic factors of humans, mosquitoes and parasites, on the evolution of Plasmodium falciparum infections, malaria transmission and genetic control methods: a review of the literature.BMC medical genomics · 2025Review
- Comparative evaluation of plasma biomarkers of Schistosoma haematobium infection in endemic populations from Burkina Faso.PLoS neglected tropical diseases · 2024Article
- Association between hemoglobin variants and laboratory outcomes in patients infected withFuture science OA · 2023Article
- Decreased parasite burden and altered host response in children with sickle cell anemia and severe anemia with malaria.Blood advances · 2021Article
- Therapeutically-rational exchange (T-REX) of Gerbich-negative red blood cells can be evaluated in Papua New Guinea as "a rescue adjunct" for patients with Plasmodium falciparum malaria.Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy · 2021Article
- Adaptive immunity selects against malaria infection blocking mutations.PLoS computational biology · 2020Article
- What will studies of Fulani individuals naturally exposed to malaria teach us about protective immunity to malaria?Scandinavian journal of immunology · 2020Review
- Comparative analysis of asexual and sexual stage Plasmodium falciparum development in different red blood cell types.Malaria journal · 2020Article
- A common polymorphism in the mechanosensitive ion channelProceedings of the National Academy of Sciences of the United States of America · 2020Observational
- Associations between red blood cell variants and malaria among children and adults from three areas of Uganda: a prospective cohort study.Malaria journal · 2020Article
- Bead-based assays to simultaneously detect multiple human inherited blood disorders associated with malaria.Malaria journal · 2019Article
- Cross sectional study on prevalence of sickle cell alleles S and C among patients with mild malaria in Ivory Coast.BMC research notes · 2018Article
- The role of the red blood cell in host defence against falciparum malaria: an expanding repertoire of evolutionary alterations.British journal of haematology · 2017Review
- Hemoglobin variants shape the distribution of malaria parasites in human populations and their transmission potential.Scientific reports · 2017Article
- Major transcriptional changes observed in the Fulani, an ethnic group less susceptible to malaria.eLife · 2017Article
- Sickle cell trait is associated with controlled levels of haem and mild proinflammatory response during acute malaria infection.Clinical and experimental immunology · 2017Article
Corrections and comments
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Authors and funding
15 authors at 6 institutions in 4 countries.
Funding
Abstract
Although hemoglobin S (HbS) and hemoglobin C (HbC) are well known to protect against severe Plasmodium falciparum malaria, conclusive evidence on their role against infection has not yet been obtained. Here we show, in 2 populations from Burkina Faso (2007-2008), that HbS is associated with a 70% reduction of harboring P. falciparum parasitemia at the heterozygous state (odds ratio [OR] for AS vs AA, 0.27; 95% confidence interval [CI], .11-.66; P = .004). There is no evidence of protection for HbC in the heterozygous state (OR for AC vs AA, 1.49; 95% CI, .69-3.21; P = .31), whereas protection even higher than that observed with AS is observed in the homozygous and double heterozygous states (OR for CC + SC vs AA, 0.04; 95% CI, .01-.29; P = .002). The abnormal display of parasite-adhesive molecules on the surface of HbS and HbC infected erythrocytes, disrupting the pathogenic process of sequestration, might displace the parasite from the deep to the peripheral circulation, promoting its elimination at the spleen level.
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Registered trials
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