Evidence map›Paper›PMID 25712970›Full record

ArticleThe Journal of infectious diseases2015

Severe Acute Respiratory Illness Deaths in Sub-Saharan Africa and the Role of Influenza: A Case Series From 8 Countries.

Meredith L McMorrow, Emile Okitolonda Wemakoy, Joelle Kabamba Tshilobo, Gideon O Emukule, Joshua A Mott, Henry Njuguna, Lilian Waiboci, Jean-Michel Heraud, Soatianana Rajatonirina, Norosoa H Razanajatovo and 19 more

Abstract read
In one paragraph

Article in The Journal of infectious diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

29 authors.

Meredith L McMorrowInfluenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention US Public Health Service, Rockville, Maryland.
Emile Okitolonda WemakoyKinshasa School of Public Health.
Joelle Kabamba TshiloboCenters for Disease Control and Prevention-Democratic Republic of the Congo, Kinshasa.
Gideon O EmukuleCenters for Disease Control and Prevention-Kenya, Nairobi.
Joshua A MottInfluenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention US Public Health Service, Rockville, Maryland Centers for Disease Control and Prevention-Kenya, Nairobi.
Henry NjugunaCenters for Disease Control and Prevention-Kenya, Nairobi.
Lilian WaibociCenters for Disease Control and Prevention-Kenya, Nairobi.
Jean-Michel HeraudNational Influenza Center, Institut Pasteur de Madagascar, Antananarivo.
Soatianana RajatonirinaNational Influenza Center, Institut Pasteur de Madagascar, Antananarivo.
Norosoa H RazanajatovoNational Influenza Center, Institut Pasteur de Madagascar, Antananarivo.
Moses ChilombeMalawi-Liverpool-Wellcome Trust Clinical Research Programme, University of Malawi College of Medicine, Blantyre.
Dean EverettMalawi-Liverpool-Wellcome Trust Clinical Research Programme, University of Malawi College of Medicine, Blantyre.
Robert S HeydermanMalawi-Liverpool-Wellcome Trust Clinical Research Programme, University of Malawi College of Medicine, Blantyre.
Amal BarakatInstitut National d 'Hygiene, Rabat, Morocco.
Thierry NyatanyiDivision of Epidemic Infectious Diseases, Rwanda Biomedical Center.
Joseph RukelibugaCenters for Disease Control and Prevention-Rwanda, Kigali.
Adam L CohenInfluenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention US Public Health Service, Rockville, Maryland Centers for Disease Control and Prevention-South Africa.
Cheryl CohenCentre for Respiratory Diseases and Meningitis School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Stefano TempiaInfluenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention Centers for Disease Control and Prevention-South Africa.
Juno ThomasOutbreak Response Unit, National Institute for Communicable Diseases.
Marietjie VenterCenters for Disease Control and Prevention-South Africa Zoonoses Research Unit, Department of Medical Virology, University of Pretoria Centre for Respiratory Diseases and Meningitis.
Elibariki MwakapejeSchool of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa Ministry of Health and Social Welfare-Tanzania.
Marcelina MponelaMinistry of Health and Social Welfare-Tanzania Centers for Disease Control and Prevention-Tanzania, Dar es Salaam.
Julius LutwamaCenters for Disease Control and Prevention-Tanzania, Dar es Salaam Uganda Virus Research Institute, Entebbe.
Jazmin DuqueInfluenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention Battelle, Atlanta, Georgia.
Kathryn LafondInfluenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention.
Ndahwouh Talla NzussouoInfluenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention.
Thelma WilliamsInfluenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention.
Marc-Alain WiddowsonInfluenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention.

Funding

Intramural CDC HHS CC999999Wellcome Trust
6 · The paper itself

Abstract

backgroundData on causes of death due to respiratory illness in Africa are limited.

methodsFrom January to April 2013, 28 African countries were invited to participate in a review of severe acute respiratory illness (SARI)-associated deaths identified from influenza surveillance during 2009-2012.

resultsTwenty-three countries (82%) responded, 11 (48%) collect mortality data, and 8 provided data. Data were collected from 37 714 SARI cases, and 3091 (8.2%; range by country, 5.1%-25.9%) tested positive for influenza virus. There were 1073 deaths (2.8%; range by country, 0.1%-5.3%) reported, among which influenza virus was detected in 57 (5.3%). Case-fatality proportion (CFP) was higher among countries with systematic death reporting than among those with sporadic reporting. The influenza-associated CFP was 1.8% (57 of 3091), compared with 2.9% (1016 of 34 623) for influenza virus-negative cases (P < .001). Among 834 deaths (77.7%) tested for other respiratory pathogens, rhinovirus (107 [12.8%]), adenovirus (64 [6.0%]), respiratory syncytial virus (60 [5.6%]), and Streptococcus pneumoniae (57 [5.3%]) were most commonly identified. Among 1073 deaths, 402 (37.5%) involved people aged 0-4 years, 462 (43.1%) involved people aged 5-49 years, and 209 (19.5%) involved people aged ≥50 years.

conclusionsFew African countries systematically collect data on outcomes of people hospitalized with respiratory illness. Stronger surveillance for deaths due to respiratory illness may identify risk groups for targeted vaccine use and other prevention strategies.

Indexed as

AdolescentAdultAfrica South of the SaharaAgedAge DistributionBacterial InfectionsChildChild, PreschoolHumansInfantInfant, NewbornInfluenza, HumanMiddle AgedPopulation SurveillanceRespiratory Tract InfectionsYoung AdultAfrica South of the Saharainfluenza, humanmortality

Identifiers

PMID25712970
PMCPMC4826902

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.