ArticleThe European journal of neuroscience2015
High-frequency stimulation of the medial prefrontal cortex decreases cellular firing in the dorsal raphe.
Article in The European journal of neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- Dopamine and serotonin transients predict depressive symptom relief following deep brain stimulation of human subcallosal cingulate cortex.bioRxiv : the preprint server for biology · 2025Article
- Dopamine Release Dynamics in the Nucleus Accumbens Are Modulated by the Timing of Electrical Stimulation Pulses When Applied to the Medial Forebrain Bundle and Medial Prefrontal Cortex.ACS chemical neuroscience · 2024Article
- Maturation of cortical input to dorsal raphe nucleus increases behavioral persistence in mice.eLife · 2024Article
- Cortical signatures of sleep are altered following effective deep brain stimulation for depression.Translational psychiatry · 2024Article
- Differential Modulation of Dorsal Raphe Serotonergic Activity in Rat Brain by the Infralimbic and Prelimbic Cortices.International journal of molecular sciences · 2023Article
- New and emerging approaches to treat psychiatric disorders.Nature medicine · 2023Review
- Serotonin 5-HTPsychopharmacology · 2022Article
- Activating Interneurons in Local Inhibitory Circuits by High-Frequency Stimulations at the Efferent Fibers of Pyramidal Neurons in Rat Hippocampal CA1 Region.Brain sciences · 2022Article
- Functional Contribution of the Medial Prefrontal Circuitry in Major Depressive Disorder and Stress-Induced Depressive-Like Behaviors.Frontiers in behavioral neuroscience · 2021Review
- Implication of 5-HT7 receptor in prefrontal circuit assembly and detrimental emotional effects of SSRIs during development.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- A Decade of Progress in Deep Brain Stimulation of the Subcallosal Cingulate for the Treatment of Depression.Journal of clinical medicine · 2020Review
- Deep brain stimulation for treatment-resistant depression: an integrative review of preclinical and clinical findings and translational implications.Molecular psychiatry · 2018Review
- Serotonergic modulation of orbitofrontal activity and its relevance for decision making and impulsivity.Human brain mapping · 2017Article
- A Computational Model of Major Depression: the Role of Glutamate Dysfunction on Cingulo-Frontal Network Dynamics.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- Characterization of oscillatory changes in hippocampus and amygdala after deep brain stimulation of the infralimbic prefrontal cortex.Physiological reports · 2016Article
- Astroglial Control of the Antidepressant-Like Effects of Prefrontal Cortex Deep Brain Stimulation.EBioMedicine · 2015Article
- Physical Interactions and Functional Relationships of Neuroligin 2 and Midbrain Serotonin Transporters.Frontiers in synaptic neuroscience · 2015Article
- A narrative review on invasive brain stimulation for treatment-resistant depression.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)Review
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
High-frequency deep brain stimulation (HFS-DBS) of the subcallosal cingulate (SCC) region has been investigated as a treatment for refractory forms of depression with a ~50% remission rate in open label studies. However, the therapeutic mechanisms of DBS are still largely unknown. Using anaesthetized Sprague Dawley rats, we recorded neuronal spiking activity in 102 neurons of the dorsal raphe (DR) before, during and after the induction of a 5-min HFS train in the infralimbic region (IL) of the medial prefrontal cortex (mPFC), the rodent homologue of the human SCC. The majority of DR cells (82%) significantly decreased firing rate during HFS (P < 0.01, 55.7 ± 4.5% of baseline, 35 rats). To assess whether mPFC-HFS mediates inhibition of DR cellular firing by stimulating local GABAergic interneurons, the GABAA antagonist bicuculline (Bic, 100 μm) was injected directly into the DR during HFS. Neurons inhibited by HFS recovered their firing rate during Bic+HFS (P < 0.01, n = 15, seven rats) to levels not different from baseline. Cells that were not affected by HFS did not change firing rate during Bic+HFS (P = 0.968, n = 7, three rats). These results indicate that blocking GABAA reverses HFS-mediated inhibition of DR neurons. As the cells that were not inhibited by HFS were also unaffected by HFS+Bic, they are probably not innervated by local GABA. Taken together, our results suggest that mPFC-HFS may exert a preferential effect on DR neurons with GABAA receptors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.