Evidence map›Paper›PMID 25712234›Full record

ArticleJournal of nephrology2015

Liver steatosis and the risk of albuminuria: the multi-ethnic study of atherosclerosis.

Ravi V Shah, Matthew A Allison, Joao A C Lima, Siddique A Abbasi, Morgana Mongraw-Chaffin, Michael Jerosch-Herold, Jingzhong Ding, Matthew J Budoff, Venkatesh L Murthy

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nephrology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Beyond Liver Function:Sultan Qaboos University medical journal · 2025
    Article
  2. Article
  3. Article
  4. Diet and adipose tissue distributions: The Multi-Ethnic Study of Atherosclerosis.Nutrition, metabolism, and cardiovascular diseases : NMCD · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 1 country.

Ravi V ShahDepartment of Cardiology and Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 185 Pilgrim Road, Suite 454-East, Boston, MA, 02215, USA. rshah1@bidmc.harvard.edu.
Matthew A AllisonDepartment of Family and Preventative Medicine, University of California-San Diego, San Diego, CA, USA.
Joao A C LimaCardiology Division, Johns Hopkins Medical Institute, Baltimore, MD, USA.
Siddique A AbbasiDepartment of Cardiology and Medicine, Brown University, Providence, RI, USA.
Morgana Mongraw-ChaffinDepartment of Family and Preventative Medicine, University of California-San Diego, San Diego, CA, USA.
Michael Jerosch-HeroldNon-Invasive Cardiovascular Imaging, Brigham and Women's Hospital, Boston, MA, USA.
Jingzhong DingDepartment of Medicine, Wake Forest Baptist Medical Center, Winston-Salem, NC, USA.
Matthew J BudoffDepartment of Cardiology and Medicine, University of California-Los Angeles, Los Angeles, CA, USA.
Venkatesh L MurthyCardiovascular Medicine Division, Department of Medicine, Nuclear Medicine and Cardiothoracic Imaging Divisions, Department of Radiology, University of Michigan, 1338 Cardiovascular Center, Ann Arbor, MI, USA. vlmurthy@med.umich.edu.
University of California, San Diego · USAtrium Health Wake Forest Baptist · USBrigham and Women's Hospital · USHarvard University · USJohn Brown University · USUniversity of California, Los Angeles · USUniversity of Michigan–Ann Arbor · US

Funding

Noninvasive Cardiovascular Imaging Research Training ProgramT32HL094301 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI Marcelo F DI CARLI · 2010 to 2026
$7.8M
UCSD Integrated Cardiovascular Epidemiology FellowshipT32HL079891 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Matthew A Allison · 2007 to 2026
$6.7M
Abdominal Body Composition, Inflammation and Cardiovascular DiseaaseR01HL088451 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ALLISON, MATTHEW A · 2007 to 2011
$2.5M
Ventricular Size and Valve Calcification Measures by CTR01HL071739 · NHLBI · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI BUDOFF, MATTHEW J · 2003 to 2010
$2.0M
Pericardial fat and subclinical and clinical measures of coronary heart diseaseR01HL085323 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI DING, JINGZHONG · 2006 to 2009
$1.6M
Adjunctive Use of Apyrase to Fibrinolytic TherapyR44HL095169 · NHLBI · APT THERAPEUTICS, INC. · PI CHEN, RIDONG · 2012 to 2013
$1.3M
SUBCLINICAL CARDIOVASCULAR DISEASE STUDYN01HC095166 · HC · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI TRACY, RUSSELL P · 1999 to 2001
$758k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY-FIELD CENTERN01HC095162 · HC · JOHNS HOPKINS UNIVERSITY · PI SZKLO, MOYSES A · 1999 to 2000
$694k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC095161 · HC · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SHEA, STEVEN · 1999 to 2001
$642k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC095165 · HC · WAKE FOREST UNIVERSITY · PI BURKE, GREGORY L · 1999 to 2001
$616k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC095160 · HC · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SAAD, MOHAMMED F · 1999 to 2001
$592k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY-FIELD CENTERN01HC095164 · HC · NORTHWESTERN UNIVERSITY · PI LIU, KIANG JOHN · 1999 to 2001
$511k
NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095169NHLBI NIH HHS N01-HC-95159NHLBI NIH HHS N01-HC-95160NHLBI NIH HHS N01-HC-95161NHLBI NIH HHS N01-HC-95162NHLBI NIH HHS N01-HC-95163NHLBI NIH HHS N01-HC-95164NHLBI NIH HHS N01-HC-95165NHLBI NIH HHS N01-HC-95166NHLBI NIH HHS N01-HC-95167NHLBI NIH HHS N01-HC-95168NHLBI NIH HHS N01-HC-95169NHLBI NIH HHS R01 HL071739NHLBI NIH HHS R01-HL-071739NHLBI NIH HHS R01 HL085323NHLBI NIH HHS R01-HL-085323NHLBI NIH HHS R01 HL088451NHLBI NIH HHS R01-HL088451NHLBI NIH HHS T32 HL079891NHLBI NIH HHS T32 HL094301
6 · The paper itself

Abstract

objectiveTo measure association between hepatic fat and albuminuria (an early marker of renal injury) in individuals without diabetes or hypertension.

methods2,281 individuals in the Multi-Ethnic Study of Atherosclerosis without diabetes or hypertension, renal disease, or excess alcohol consumption underwent computed tomography (CT) for assessment of liver attenuation (marker of hepatic lipid content) and urinalysis (for albuminuria) at initial study visit, with assessment of incident and prevalent albuminuria by logistic regression in follow-up.

resultsAfter adjustment for age, gender, race, smoking, blood pressure, insulin resistance, and body mass index, individuals with less liver fat (higher liver CT attenuation) had a lower probability of having albuminuria at Exam 1 (OR per 10 unit increase in attenuation 0.77, 95 % CI 0.61-0.97, P = 0.02). At median 9.3 years follow-up, albuminuria was identified in 129 individuals were (5.8 %). In fully adjusted models (with age, smoking, body mass index, blood pressure, diabetes and hypertension as time-dependent covariates), lower liver attenuation (greater liver fat) was associated with higher risk of incident albuminuria (OR 0.79, 95 % CI 0.66-0.94, P = 0.008).

conclusionsHepatic attenuation is associated with prevalent and incident albuminuria, an early, potent risk factor for renal risk in a population not clearly at risk for future renal failure.

Indexed as

EthnicityAgedAlbuminuriaAtherosclerosisCreatinineFatty LiverFemaleFollow-Up StudiesHumansIncidenceMaleMiddle AgedNephelometry and TurbidimetryPrevalenceRisk AssessmentRisk FactorsCreatinineAlbuminuriaHepatic steatosisInflammationObesity

Identifiers

PMID25712234
PMCPMC4549235
OpenAlexW1991478814

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.