Evidence map›Paper›PMID 25712210›Full record

ArticleThe EMBO journal2015

The BAFFling function of Syk in B-cell homeostasis.

Sebastian Königsberger, Friedemann Kiefer

Open access · bronzeAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in The EMBO journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Sebastian KönigsbergerMammalian Cell Signaling Laboratory, Max Planck Institute for Molecular Biomedicine, Münster, Germany.
Friedemann KieferMammalian Cell Signaling Laboratory, Max Planck Institute for Molecular Biomedicine, Münster, Germany.ORCID http://orcid.org/0000-0002-3002-8237
Max Planck Institute for Molecular Biomedicine · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The TNF receptor family member BAFFR is essential for providing mature B cells with pro-survival signals and has recently been claimed to transduce these, though not exclusively, via a Syk-dependent signaling hub that feeds into ERK/AKT activation. In this issue of The EMBO Journal, Hobeika et al (2015) describe a synergistic prosurvival scenario involving BAFFR and CD19, which remains functional under Syk null conditions and is able to maintain mature B-cell survival. The authors hence propose a BAFFR-/CD19-driven mechanism to act in parallel with homeostatic NF-κB/AKT activation in non-stimulated B cells.

Indexed as

AnimalsAntigens, CD19B-Cell Activation Factor ReceptorB-LymphocytesIntracellular Signaling Peptides and ProteinsProtein-Tyrosine KinasesSignal TransductionSyk KinaseAntigens, CD19B-Cell Activation Factor ReceptorIntracellular Signaling Peptides and ProteinsProtein-Tyrosine KinasesSyk KinaseSyk protein, mouseTnfrsf13c protein, mouse

Identifiers

PMID25712210
PMCPMC4388594
OpenAlexW2107756888

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.