ArticleCancer prevention research (Philadelphia, Pa.)2015
NOTCH mutations: multiple faces in human malignancies.
Article in Cancer prevention research (Philadelphia, Pa.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 38 citations in OpenAlex.
- Targeting notch signaling pathway in esophageal cancer: from molecular insights to therapies.Oncology reviews · 2026Review
- Using Drosophila to uncover the role of organismal physiology and the tumor microenvironment in cancer.Trends in cancer · 2024Review
- Review
- Bone marrow mesenchymal stem cells promote prostate cancer cell stemness via cell-cell contact to activate the Jagged1/Notch1 pathway.Cell & bioscience · 2021Article
- Clinical Features and Prognostic Significance ofFrontiers in oncology · 2021Article
- NOTCH-1 Gene Mutations Influence Survival in Acute Myeloid Leukemia Patients.Asian Pacific journal of cancer prevention : APJCP · 2020Article
- Pathway perturbations in signaling networks: Linking genotype to phenotype.Seminars in cell & developmental biology · 2020Review
- Bone Marrow Stromal Cells Drive Key Hallmarks of B Cell Malignancies.International journal of molecular sciences · 2020Review
- Cancer genome landscape: a radiologist's guide to cancer genome medicine with imaging correlates.Insights into imaging · 2019Review
- Updates on the Role of Molecular Alterations and NOTCH Signalling in the Development of Neuroendocrine Neoplasms.Journal of clinical medicine · 2019Review
- Cellular plasticity and metastasis in breast cancer: a pre- and post-malignant problem.Journal of cancer metastasis and treatment · 2019Article
- The Role of Notch Signaling and Leptin-Notch Crosstalk in Pancreatic Cancer.Medicines (Basel, Switzerland) · 2018Review
- The NOTCH Pathway in Head and Neck Squamous Cell Carcinoma.Journal of dental research · 2018Review
- Notch1 regulates tongue cancer cells proliferation, apoptosis and invasion.Cell cycle (Georgetown, Tex.) · 2018Article
- Therapies targeting cancer stem cells: Current trends and future challenges.World journal of stem cells · 2015Review
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Authors and funding
1 author at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
NOTCH proteins have been implicated in multiple cellular functions, such as stem cell maintenance and cell fate determination. Initially identified as proto-oncogenes because they promote the development of certain types of leukemia, inactivating mutations of NOTCH were later reported. Together with the potential distinct functions of NOTCH family members, their ligands and associated niches, the precise roles of NOTCH in human cancers, particularly solid tumors, remain unsettled. In oral squamous cell carcinoma (OSCC), mutations of NOTCH1 are found in 10% to 15% tumors from Caucasian patients, mostly inactivating mutations. Recent studies of OSCC from Chinese patients, however, showed mutation rates of NOTCH1 about 50% with a considerable portion of potential activating mutations. These findings add another twist into the already complex picture of NOTCH alterations in human cancers, calling for further investigation to uncover what role exactly these molecules play in cancer initiation and progression to develop strategies targeting NOTCH signaling for cancer prevention and treatment.
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