ArticleInfluenza and other respiratory viruses2015
Results of a pilot study using self-collected mid-turbinate nasal swabs for detection of influenza virus infection among pregnant women.
Article in Influenza and other respiratory viruses, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Comparison of Respiratory Specimen Collection Methods for Detection of Influenza Virus Infection by Reverse Transcription-PCR: a Literature Review.Journal of clinical microbiology · 2019Pooled it
- Study of Healthcare Personnel with Influenza and other Respiratory Viruses in Israel (SHIRI): study protocol.BMC infectious diseases · 2018Trial
- Diagnostic Performance of Self-Collected Respiratory Swabs for SARS-CoV-2 and Influenza Virus in Community-Dwelling Older Adults.Influenza and other respiratory viruses · 2026Article
- Incidence of laboratory-confirmed influenza and RSV and associated presenteeism and absenteeism among healthcare personnel, Israel, influenza seasons 2016 to 2019.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2024Article
- Duration of Enterovirus D68 RNA Shedding in the Upper Respiratory Tract and Transmission among Household Contacts, Colorado, USA.Emerging infectious diseases · 2023Article
- Requirements and Study Designs for U.S. Regulatory Approval of Influenza Home Tests.Journal of clinical microbiology · 2022Review
- Anatomical Site, Viral Ribonucleic Acid Abundance, and Time of Sampling Correlate With Molecular Detection of Severe Acute Respiratory Syndrome Coronavirus 2 During Infection.Open forum infectious diseases · 2022Article
- Diagnostic Accuracy of an At-Home, Rapid Self-test for Influenza: Prospective Comparative Accuracy Study.JMIR public health and surveillance · 2022Article
- Performance of Unobserved Self-Collected Nasal Swabs for Detection of SARS-CoV-2 by RT-PCR Utilizing a Remote Specimen Collection Strategy.Open forum infectious diseases · 2021Article
- Home collection of nasal swabs for detection of influenza in the Household Influenza Vaccine Evaluation Study.Influenza and other respiratory viruses · 2021Article
- False negative rate of COVID-19 PCR testing: a discordant testing analysis.Virology journal · 2021Article
- Article
- Factors associated with recruitment, surveillance participation, and retention in an observational study of pregnant women and influenza.BMC pregnancy and childbirth · 2019Observational
- The Pregnancy and Influenza Multinational Epidemiologic (PRIME) study: a prospective cohort study of the impact of influenza during pregnancy among women in middle-income countries.Reproductive health · 2018Article
- Pilot study of participant-collected nasal swabs for acute respiratory infections in a low-income, urban population.Clinical epidemiology · 2016Article
- Self-Collected Nasal Swabs for Respiratory Virus Surveillance.Open forum infectious diseases · 2015Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundWe evaluated the feasibility of asking pregnant women to self-collect and ship respiratory specimens.
methodsIn a preliminary laboratory study, we compared the RT-PCR cycle threshold (CT) values of influenza A and B viruses incubated at 4 storage temperatures (from 4 to 35°C) for 6 time periods (8, 24, 48, 72, and 168 hours and 30 days), resulting in 24 conditions that were compared to an aliquot tested after standard freezing (-20°C) (baseline condition). In a subsequent pilot study, during January-February, 2014, we delivered respiratory specimen collection kits to 53 pregnant women with a medically attended acute respiratory illness using three delivery methods.
resultsCT values were stable after storage at temperatures <27°C for up to 72 hours for influenza A viruses and 48 hours for influenza B viruses. Of 53 women who received kits during the pilot, 89% collected and shipped nasal swabs as requested. However, 30% (14/47) of the women took over 2 days to collect and ship their specimen. The human control gene, ribonuclease P (RNase P), was detected in 100% of nasal swab specimens. However, the mean CT values for RNase P (26.5, 95% confidence interval [CI] = 26.0-27.1) and for the 8 influenza A virus positives in our pilot (32.2, 95% CI = 28.9-35.5) were significantly higher than the CTs observed in our 2010-2012 study using staff-collected nasal pharyngeal swabs (P-values < 0.01). DISCUSSION: Self-collection of respiratory specimens is a promising research method, but further research is needed to quantify the sensitivity and specificity of the approach.
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