Evidence map›Paper›PMID 25711873›Full record

ArticleInfluenza and other respiratory viruses2015

Influenza seasonality in Madagascar: the mysterious African free-runner.

Wladimir Jimenez Alonso, Julia Guillebaud, Cecile Viboud, Norosoa Harline Razanajatovo, Arnaud Orelle, Steven Zhixiang Zhou, Laurence Randrianasolo, Jean-Michel Heraud

Abstract read
In one paragraph

Article in Influenza and other respiratory viruses, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  18. Timing and periodicity of influenza epidemics.Proceedings of the National Academy of Sciences of the United States of America · 2016
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Wladimir Jimenez AlonsoFogarty International Center, National Institutes of Health, Bethesda, MD, USA.
Julia Guillebaud
Cecile Viboud
Norosoa Harline Razanajatovo
Arnaud Orelle
Steven Zhixiang Zhou
Laurence Randrianasolo
Jean-Michel Heraud

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe seasonal drivers of influenza activity remain debated in tropical settings where epidemics are not clearly phased. Antananarivo is a particularly interesting case study because it is in Madagascar, an island situated in the tropics and with quantifiable connectivity levels to other countries.

objectivesWe aimed at disentangling the role of environmental forcing and population fluxes on influenza seasonality in Madagascar.

methodsWe compiled weekly counts of laboratory-confirmed influenza-positive specimens for the period 2002 to 2012 collected in Antananarivo, with data available from sub-Saharan countries and countries contributing most foreign travelers to Madagascar. Daily climate indicators were compiled for the study period.

resultsOverall, influenza activity detected in Antananarivo predated that identified in temperate Northern Hemisphere locations. This activity presented poor temporal matching with viral activity in other countries from the African continent or countries highly connected to Madagascar excepted for A(H1N1)pdm09. Influenza detection in Antananarivo was not associated with travel activity and, although it was positively correlated with all climatic variables studied, such association was weak.

conclusionsThe timing of influenza activity in Antananarivo is irregular, is not driven by climate, and does not align with that of countries in geographic proximity or highly connected to Madagascar. This work opens fresh questions regarding the drivers of influenza seasonality globally particularly in mid-latitude and less-connected regions to tailor vaccine strategies locally.

Indexed as

Influenza A Virus, H1N1 SubtypeInfluenza A Virus, H3N2 SubtypeInfluenza B virusClimateEpidemicsHumansInfluenza, HumanInfluenza VaccinesMadagascarSeasonsSentinel SurveillanceTime FactorsTravelInfluenza VaccinesInfluenzaMadagascarpopulation connectivityseasonalitytime seriesviral migration

Identifiers

PMID25711873
PMCPMC4415694

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.