ArticleNature genetics2015
Big Bang and context-driven collapse.
Article in Nature genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- The end of the genetic paradigm of cancer.PLoS biology · 2025Review
- Application of Advanced Mass Spectrometry-Based Proteomics to Study Hypoxia Driven Cancer Progression.Frontiers in oncology · 2021Review
- Eco-oncology: Applying ecological principles to understand and manage cancer.Ecology and evolution · 2020Review
- When, why and how tumour clonal diversity predicts survival.Evolutionary applications · 2020Article
- Model genotype-phenotype mappings and the algorithmic structure of evolution.Journal of the Royal Society, Interface · 2019Article
- Cancer Ecology and Evolution: Positive interactions and system vulnerability.Current opinion in systems biology · 2019Article
- Modeling genetic heterogeneity of drug response and resistance in cancer.Current opinion in systems biology · 2019Article
- Spatial mutation patterns as markers of early colorectal tumor cell mobility.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Division-independent differentiation mandates proliferative competition among stem cells.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Homeostasis Back and Forth: An Ecoevolutionary Perspective of Cancer.Cold Spring Harbor perspectives in medicine · 2017Review
- Spatial genomic heterogeneity in multiple myeloma revealed by multi-region sequencing.Nature communications · 2017Article
- Stochasticity in the Genotype-Phenotype Map: Implications for the Robustness and Persistence of Bet-Hedging.Genetics · 2016Article
- Similar but different: distinct roles for KRAS and BRAF oncogenes in colorectal cancer development and therapy resistance.Oncotarget · 2015Review
- Cancer Community Ecology.Cancer control : journal of the Moffitt Cancer CenterArticle
Corrections and comments
- Comment on
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heterogeneity is the single most important factor driving cancer progression and treatment failure, yet little is understood about how and when this heterogeneity arises. A new study shows that colorectal cancers acquire their dominant mutations early in development and that subsequent mutations, even if they confer greater fitness, are unlikely to sweep through the tumor.
Indexed as
Identifiers
25711865What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.