Evidence map›Paper›PMID 25711712›Full record

ArticleJournal of medicinal chemistry2015

Tailored near-infrared contrast agents for image guided surgery.

Costyl N Njiojob, Eric A Owens, Lakshminarayana Narayana, Hoon Hyun, Hak Soo Choi, Maged Henary

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medicinal chemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed.

  1. More Than a Glow: How Cyanine Dyes Shape Tracer Pharmacokinetics.Angewandte Chemie (International ed. in English) · 2026
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  6. Tissue-seeking dyes for in vivo applications.Smart molecules : open access · 2024
    Review
  7. Thermal Truncation of Heptamethine Cyanine Dyes.Journal of the American Chemical Society · 2024
    Article
  8. Review
  9. Article
  10. Unraveling the Chemistry ofACS bio & med chem Au · 2022
    Article
  11. Article
  12. Article
  13. Molecular Tuning of IR-786 for Improved Brown Adipose Tissue Imaging.International journal of molecular sciences · 2022
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Costyl N Njiojob†Department of Chemistry, Center for Diagnostics and Therapeutics and The Center for Biotechnology and Drug Design, Georgia State University, 100 Piedmont Road SE, Atlanta, Georgia 30303, United States.
Eric A Owens†Department of Chemistry, Center for Diagnostics and Therapeutics and The Center for Biotechnology and Drug Design, Georgia State University, 100 Piedmont Road SE, Atlanta, Georgia 30303, United States.
Lakshminarayana Narayana†Department of Chemistry, Center for Diagnostics and Therapeutics and The Center for Biotechnology and Drug Design, Georgia State University, 100 Piedmont Road SE, Atlanta, Georgia 30303, United States.
Hoon Hyun‡Division of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, United States.
Hak Soo Choi‡Division of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, United States.
Maged Henary†Department of Chemistry, Center for Diagnostics and Therapeutics and The Center for Biotechnology and Drug Design, Georgia State University, 100 Piedmont Road SE, Atlanta, Georgia 30303, United States.

Funding

Image-Guided Surgery of Endocrine Glands and Their Tumors using Near-Infrared FluR01EB011523 · NIBIB · BETH ISRAEL DEACONESS MEDICAL CENTER · PI CHOI, HAK SOO · 2010 to 2013
$2.0M
NIBIB NIH HHS R01 EB011523NIBIB NIH HHS R01-EB-011523
6 · The paper itself

Abstract

The success of near-infrared (NIR) fluorescence to be employed for intraoperative imaging relies on the ability to develop a highly stable, NIR fluorescent, nontoxic, biocompatible, and highly excreted compound that retains a reactive functionality for conjugation to a cancer-recognizing peptide. Herein, systematic modifications to previously detailed fluorophore ZW800-1 are explored. Specific modifications, including the isosteric replacement of the O atom of ZW800-1, include nucleophilic amine and sulfur species attached to the heptamethine core. These novel compounds have shown similar satisfactory results in biodistribution and clearance while also expressing increased stability in serum. Most importantly, all of the synthesized and evaluated compounds display a reactive functionality (either a free amino group or carboxylic acid moiety) for further bioconjugation. The results obtained from the newly prepared derivatives demonstrate that the central substitution with the studied linking agents retains the ultralow background in vivo performance of the fluorophores regardless of the total net charge.

Indexed as

Optical ImagingSurgery, Computer-AssistedAnimalsComputer SimulationContrast MediaFluorescent DyesInfrared RaysMaleMiceModels, MolecularNeoplasmsQuaternary Ammonium CompoundsSulfonic AcidsContrast MediaFluorescent DyesQuaternary Ammonium CompoundsSulfonic AcidsZW800-1 compound

Identifiers

PMID25711712
PMCPMC4388048

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.