ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2016
Inflammatory and Glutamatergic Homeostasis Are Involved in Successful Aging.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 26 citations in OpenAlex.
- The impact of growth hormone (GH) on immunosenescence: exploring the role of B and T cells.Pituitary · 2026Article
- Article
- IGF/IGF-1R signal pathway in pain: a promising therapeutic target.International journal of biological sciences · 2023Review
- Friend or Foe? Defining the Role of Glutamate in Aging and Alzheimer's Disease.Frontiers in aging · 2022Review
- Benefits of Living Without Growth Hormone.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- Growth Hormone and Aging: New Findings.The world journal of men's health · 2021Review
- Riluzole attenuates glutamatergic tone and cognitive decline in AβPP/PS1 mice.Journal of neurochemistry · 2021Article
- Age-Related Cognitive Impairment: Role of Reduced Synaptobrevin-2 Levels in Deficits of Memory and Synaptic Plasticity.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Article
- Growth Hormone Deficiency: Health and Longevity.Endocrine reviews · 2019Review
- Growth Hormone and Aging: Updated Review.The world journal of men's health · 2019Review
- Impact of Growth Hormone-Related Mutations on Mammalian Aging.Frontiers in genetics · 2018Review
- Article
- Effects of ibuprofen on cognition and NMDA receptor subunit expression across aging.Neuroscience · 2017Article
- Enhanced Cognition and Hypoglutamatergic Signaling in a Growth Hormone Receptor Knockout Mouse Model of Successful Aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Article
- GH and ageing: Pitfalls and new insights.Best practice & research. Clinical endocrinology & metabolism · 2017Review
- Microglia Priming with Aging and Stress.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Review
- Healthspan and longevity can be extended by suppression of growth hormone signaling.Mammalian genome : official journal of the International Mammalian Genome Society · 2016Review
- The somatotropic axis and aging: Benefits of endocrine defects.Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Whole body studies using long-lived growth hormone receptor gene disrupted or knock out (GHR-KO) mice report global GH resistance, increased insulin sensitivity, reduced insulin-like growth factor 1 (IGF-1), and cognitive retention in old-age, however, little is known about the neurobiological status of these mice. The aim of this study was to determine if glutamatergic and inflammatory markers that are altered in aging and/or age-related diseases and disorders, are preserved in mice that experience increased healthspan. We examined messenger ribonucleic acid (mRNA) expression levels in the brain of 4- to 6-, 8- to 10-, and 20- to 22-month GHR-KO and normal aging control mice. In the hippocampus, glutamate transporter 1 (GLT-1) and anti-inflammatory nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB)-p50 were elevated in 8- to 10-month GHR-KO mice compared with age-matched controls. In the hypothalamus, NFκB-p50, NFκB-p65, IGF-1 receptor (IGF-1R), glutamate/aspartate transporter (GLAST), and 2-amino-3-(5-methyl-3-oxo 2,3-dihydro-1,2 oxazol-4-yl) propanoic acid receptor subunit 1 (GluA1) were elevated in 8- to 10- and/or 20- to 22-month GHR-KO mice when comparing genotypes. Finally, interleukin 1-beta (IL-1β) mRNA was reduced in 4- to 6- and/or 8- to 10-month GHR-KO mice compared with normal littermates in all brain areas examined. These data support the importance of decreased brain inflammation in early adulthood and maintained homeostasis of the glutamatergic and inflammatory systems in extended longevity.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.