ArticleAnalytical chemistry2015
Carbon nanopipette electrodes for dopamine detection in Drosophila.
Article in Analytical chemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 111 citations in OpenAlex.
- Chemically Selective Nanoelectrode Arrays for Real-Time, Parallel Neurotransmitter and Electrical Recording.Small science · 2026Article
- Nanomaterial Modification of Ultramicroelectrodes Using Design-of-Experiments Principles.ACS electrochemistry · 2026Article
- Selective Detection of Acetylcholine against Choline and In Vivo Measurement in the Mouse Brain Using the Micropipet-Supported Liquid/Liquid Interface Electrode.ACS measurement science au · 2025Article
- Scalable Electrophysiology of Millimeter-Scale Animals with Electrode Devices.BME frontiers · 2023Review
- Ion Current Rectification and Long-Range Interference in Conical Silicon Micropores.ACS applied materials & interfaces · 2022Article
- Micro- and nano-devices for electrochemical sensing.Mikrochimica acta · 2022Review
- Carbon microelectrodes with customized shapes for neurotransmitter detection: A review.Analytica chimica acta · 2022Review
- Carbon nanospike coated nanoelectrodes for measurements of neurotransmitters.Faraday discussions · 2022Article
- Construction of a Au@MoSRSC advances · 2021Article
- 3D fuzzy graphene microelectrode array for dopamine sensing at sub-cellular spatial resolution.Biosensors & bioelectronics · 2021Article
- Electroless deposition of gold nanoparticles on carbon nanopipette electrode for electrochemical detection of catecholamines released from PC12 cells.Mikrochimica acta · 2020Article
- 3D-Printed Carbon Nanoelectrodes for In Vivo Neurotransmitter Sensing.Nano letters · 2020Article
- Nanoelectrochemistry in the study of single-cell signaling.Analytical and bioanalytical chemistry · 2020Review
- Needle-type organic electrochemical transistor for spatially resolved detection of dopamine.Mikrochimica acta · 2020Article
- Recent advances in fast-scan cyclic voltammetry.The Analyst · 2020Review
- Recent Advances in Electrochemical and Optical Sensing of Dopamine.Sensors (Basel, Switzerland) · 2020Review
- Nanopipette-assisted single cell metabolic glycan labeling.RSC advances · 2019Article
- Electrochemistry at the Synapse.Annual review of analytical chemistry (Palo Alto, Calif.) · 2019Review
- Cavity Carbon-Nanopipette Electrodes for Dopamine Detection.Analytical chemistry · 2019Article
- Review: New insights into optimizing chemical and 3D surface structures of carbon electrodes for neurotransmitter detection.Analytical methods : advancing methods and applications · 2019Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Small, robust, sensitive electrodes are desired for in vivo neurotransmitter measurements. Carbon nanopipettes have been previously manufactured and used for single-cell drug delivery and electrophysiological measurements. Here, a modified fabrication procedure was developed to produce batches of solid carbon nanopipette electrodes (CNPEs) with ∼250 nm diameter tips, and controllable lengths of exposed carbon, ranging from 5 to 175 μm. The electrochemical properties of CNPEs were characterized with fast-scan cyclic voltammetry (FSCV) for the first time. CNPEs were used to detect the electroactive neurotransmitters dopamine, serotonin, and octopamine. CNPEs were significantly more sensitive for serotonin detection than traditional carbon-fiber microelectrodes (CFMEs). Similar to CFMEs, CNPEs have a linear response for dopamine concentrations ranging from 0.1 to 10 μM and a limit of detection of 25 ± 5 nM. Recordings with CNPEs were stable for over 3 h when the applied triangle waveform was scanned between -0.4 and +1.3 V vs Ag/AgCl/Cl(-) at 400 V/s. CNPEs were used to detect endogenous dopamine release in Drosophila larvae using optogenetics, which verified the utility of CNPEs for in vivo neuroscience studies. CNPEs are advantageous because they are 1 order of magnitude smaller in diameter than typical CFMEs and have a sharp, tunable geometry that facilitates penetration and implantation for localized measurements in distinct regions of small organisms, such as the Drosophila brain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.