Evidence map›Paper›PMID 25711299›Full record

ArticleAIDS and behavior2016

Alcohol-Related Diagnoses and All-Cause Hospitalization Among HIV-Infected and Uninfected Patients: A Longitudinal Analysis of United States Veterans from 1997 to 2011.

Christopher Rentsch, Janet P Tate, Kathleen M Akgün, Stephen Crystal, Karen H Wang, S Ryan Greysen, Emily A Wang, Kendall J Bryant, David A Fiellin, Amy C Justice and 1 more

Erratum issuedAbstract read
In one paragraph

Article in AIDS and behavior, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. Trial
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  4. Article
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  6. Changes in the Prevalence of Non-AIDS Conditions Among Hospitalized Persons With HIV in the United States and Canada, 2008-2018.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Association of the VACS Index With Hospitalization Among People With HIV in the NA-ACCORD.Journal of acquired immune deficiency syndromes (1999) · 2022
    Article
  11. Article
  12. Hospitalization Rates and Outcomes Among Persons Living With Human Immunodeficiency Virus in the Southeastern United States, 1996-2016.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Frailty and Cause-Specific Hospitalization Among Persons Aging With HIV Infection and Injection Drug Use.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Christopher RentschInfectious Diseases, Atlanta VA Medical Center, Decatur, GA, USA. christopher.rentsch@va.gov.
Janet P TateResearch, VA Connecticut Healthcare System, West Haven, CT, USA.
Kathleen M AkgünResearch, VA Connecticut Healthcare System, West Haven, CT, USA.
Stephen CrystalSchool of Social Work, Rutgers University, New Brunswick, NJ, USA.
Karen H WangResearch, VA Connecticut Healthcare System, West Haven, CT, USA.
S Ryan GreysenDivision of Hospital Medicine, University of California, San Francisco, CA, USA.
Emily A WangSchool of Medicine, Yale University, New Haven, CT, USA.
Kendall J BryantNational Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA.
David A FiellinSchool of Medicine, Yale University, New Haven, CT, USA.
Amy C JusticeResearch, VA Connecticut Healthcare System, West Haven, CT, USA.
David RimlandInfectious Diseases, Atlanta VA Medical Center, Decatur, GA, USA.

Funding

Using Coincidence Analysis to Investigate Factors Affecting PrEP Initiation and Continuation in Southern ending the Epidemic CountiesP30MH062294 · NIMH · YALE UNIVERSITY · PI John Edward Pachankis · 2001 to 2026
$48.5M
Alcohol Associated Outcomes Among HIV+/- Aging VeteransU10AA013566 · NIAAA · YALE UNIVERSITY · PI JUSTICE, AMY CAROLINE · 2006 to 2010
$12.7M
Alcohol Associated Outcomes Among HIV+/-Aging VeteransU01AA013566 · NIAAA · YALE UNIVERSITY · PI JUSTICE, AMY CAROLINE · 2002 to 2005
$10.1M
Alcohol and Multisubstance Use in the Veterans Aging Cohort StudyU01AA020790 · NIAAA · YALE UNIVERSITY · PI JUSTICE, AMY CAROLINE · 2011 to 2020
$7.7M
Cardiovascular Disease Mechanisms in HIV Infected and Uninfected VeteransR01HL095136 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FREIBERG, MATTHEW S, JUSTICE, AMY CAROLINE · 2008 to 2012
$5.6M
Sex Disparities in Overall Response to ART Among HIV Infected IndividualsU24AA020794 · NIAAA · YALE UNIVERSITY · PI JUSTICE, AMY CAROLINE · 2011 to 2020
$5.5M
Integrated Stepped Care for Unhealthy Alcohol Use in HIVU01AA020795 · NIAAA · YALE UNIVERSITY · PI FIELLIN, DAVID · 2011 to 2020
$5.2M
Longitudinal Studies of HIV-Associated Lung Infections and ComplicationsR01HL090342 · NHLBI · YALE UNIVERSITY · PI CROTHERS, KRISTINA ANNE · 2007 to 2011
$4.0M
The Operations Research Collaboration for Alcohol Abuse and AIDS: ORCAAAU24AA022007 · NIAAA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BRAITHWAITE, RONALD SCOTT · 2012 to 2016
$3.4M
Translational Research on Alcohol, Immunodeficiency, and Aging In COMpAAASU24AA022001 · NIAAA · YALE UNIVERSITY · PI BRANDT, CYNTHIA A. · 2012 to 2020
$3.2M
Benefits and Harms of Lung Cancer Screening in HIV InfectionR01CA173754 · NCI · UNIVERSITY OF WASHINGTON · PI BRAITHWAITE, RONALD SCOTT, CROTHERS, KRISTINA ANNE · 2013 to 2017
$2.5M
Clinical Prediction of Hepatotoxicity & Comparative Hepatic Safety of MedicationsR01HS018372 · AHRQ · UNIVERSITY OF PENNSYLVANIA · PI LO RE, VINCENT · 2010 to 2014
$2.5M
AHRQ HHS R01 HS018372AHRQ HHS R01-HS018372NCI NIH HHS R01 CA173754NHLBI NIH HHS R01 HL090342NHLBI NIH HHS R01-HL090342NHLBI NIH HHS R01 HL095136NHLBI NIH HHS R01-HL095136NIAAA NIH HHS R01 AA013566NIAAA NIH HHS U01 AA013566NIAAA NIH HHS U01 AA020790NIAAA NIH HHS U01-AA020790NIAAA NIH HHS U01 AA020795NIAAA NIH HHS U01-AA020795NIAAA NIH HHS U01 AA020799NIAAA NIH HHS U01-AA020799NIAAA NIH HHS U10 AA013566NIAAA NIH HHS U13 AA022864NIAAA NIH HHS U24 AA020794NIAAA NIH HHS U24-AA020794NIAAA NIH HHS U24 AA022001NIAAA NIH HHS U24-AA022001NIAAA NIH HHS U24 AA022007NIDA NIH HHS R01 DA035616NIDA NIH HHS R01DA035616NIMH NIH HHS P30 MH062294NIMH NIH HHS P30-MH062294PHS HHS U01-A1069918
6 · The paper itself

Abstract

Individuals with HIV infection are living substantially longer on antiretroviral therapy, but hospitalization rates continue to be relatively high. We do not know how overall or diagnosis-specific hospitalization rates compare between HIV-infected and uninfected individuals or what conditions may drive hospitalization trends. Hospitalization rates among United States Veterans were calculated and stratified by HIV serostatus and principal diagnosis disease category. Because alcohol-related diagnoses (ARD) appeared to have a disproportional effect, we further stratified our calculations by ARD history. A multivariable Cox proportional hazards model was fitted to assess the relative risk of hospitalization controlling for demographic and other comorbidity variables. From 1997 to 2011, 46,428 HIV-infected and 93,997 uninfected patients were followed for 1,497,536 person-years. Overall hospitalization rates decreased among HIV-infected and uninfected patients. However, cardiovascular and renal insufficiency admissions increased for all groups while gastrointestinal and liver, endocrine, neurologic, and non-AIDS cancer admissions increased among those with an alcohol-related diagnosis. After multivariable adjustment, HIV-infected individuals with an ARD had the highest risk of hospitalization (hazard ratio 3.24, 95 % CI 3.00, 3.49) compared to those free of HIV infection and without an ARD. Still, HIV alone also conferred increased risk (HR 2.08, 95 % CI 2.04, 2.13). While decreasing overall, risk of all-cause hospitalization remains higher among HIV-infected than uninfected individuals and is strongly influenced by the presence of an ARD.

Indexed as

AdultAgingAlcohol DrinkingAlcoholismCase-Control StudiesComorbidityFemaleHIV InfectionsHospitalizationHumansLongitudinal StudiesMaleMiddle AgedMultivariate AnalysisPatient AdmissionProportional Hazards ModelsAgingClinical epidemiologyHIVInpatient careSubstance abuse

Identifiers

PMID25711299
PMCPMC4550577

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.