ArticleEuropean journal of nuclear medicine and molecular imaging2015
Stress-first protocol for myocardial perfusion SPECT imaging with semiconductor cameras: high diagnostic performances with significant reduction in patient radiation doses.
Article in European journal of nuclear medicine and molecular imaging, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 3 of them syntheses that pooled it.
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Who cites it
40 citing papers in PubMed, 3 syntheses or guidelines pooled it, 81 citations in OpenAlex.
- Prognostic value of myocardial perfusion imaging by cadmium zinc telluride single-photon emission computed tomography in patients with suspected or known coronary artery disease: a systematic review and meta-analysis.European journal of nuclear medicine and molecular imaging · 2023Pooled it
- Diagnostic performance of myocardial perfusion imaging with conventional and CZT single-photon emission computed tomography in detecting coronary artery disease: A meta-analysis.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Pooled it
- Pooled it
- Assessment of Myocardial CZT SPECT Recording in a Forward-Leaning Bikerlike Position.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2019Trial
- Cardiovascular Testing in the United States during the COVID-19 Pandemic: Volume Recovery and Worldwide Comparison.Radiology. Cardiothoracic imaging · 2023Article
- Routine first-line detection of breast cancer therapy-related cardiotoxicity by serial, fast and ultra-low-dose equilibrium radionuclide angiography.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Prognostic value of combined coronary angiography-derived IMR and myocardial perfusion imaging by CZT SPECT in INOCA.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Deep learning prediction of quantitative coronary angiography values using myocardial perfusion images with a CZT camera.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Patient Selection and Clinical Indication for Chronic Total Occlusion Revascularization-A Workflow Focusing on Non-Invasive Cardiac Imaging.Life (Basel, Switzerland) · 2022Review
- Functional stress imaging to predict abnormal coronary fractional flow reserve: the PACIFIC 2 study.European heart journal · 2022Article
- Assessment of the routine reporting of very low-dose exercise-first myocardial perfusion SPECT from a large-scale real-world cohort and correlation with the subsequent reporting of coronary stenosis at angiography.European journal of nuclear medicine and molecular imaging · 2022Article
- Optimal Protocol of Myocardial Perfusion Imaging for Reduction of Radiation Exposure.Annals of nuclear cardiology · 2022Review
- Prognostic value of myocardial perfusion imaging with D-SPECT camera in patients with ischemia and no obstructive coronary artery disease (INOCA).Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- High quality attenuation-corrected myocardial perfusion images may be achieved in patients with morbid obesity using a whole-body CZT camera and a low-dose injection protocol.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Effects of gender and defect reversibility on detection of coronary disease with an upright and supine cadmium-zinc-telluride camera.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Low-dose gated bloodpool SPECT: Is it time to make the shift?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Radiation exposure after myocardial perfusion imaging with Cadmium-Zinc-Telluride camera versus conventional camera.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Prognostically safe stress-only single-photon emission computed tomography myocardial perfusion imaging guided by machine learning: report from REFINE SPECT.European heart journal. Cardiovascular Imaging · 2021Article
- Impact of Valve Plane Alignment on the Repeatability of Left Ventricular Ejection Fraction in ECG-gatedMyocard ial SPECT Using Corridor 4DM.Annals of nuclear cardiology · 2021Article
- Low-dose dynamic myocardial perfusion imaging by CZT-SPECT in the identification of obstructive coronary artery disease.European journal of nuclear medicine and molecular imaging · 2020Article
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeEffective doses of 14 mSv or higher are currently being attained in patients having stress and rest myocardial perfusion imaging (MPI) single photon emission computed tomography (SPECT) performed on the same day with conventional protocols. This study aimed to assess the actual reduction in effective doses as well as diagnostic performances for MPI routinely planned with: (1) high-sensitivity cadmium zinc telluride (CZT) cameras, (2) very low injected activities and (3) a stress-first protocol where the normality of stress images may lead to avoiding rest imaging.
methodsDuring a 1-year period, 2,845 patients had MPI on a CZT camera, a single-day stress-first protocol and low injected activities (120 MBq of (99m)Tc-sestamibi at stress for 75 kg body weight and threefold higher at rest). The ability to detect > 50% coronary stenosis was assessed in a subgroup of 149 patients who also had coronary angiography, while the normalcy rate was assessed in a subgroup of 128 patients with a low pretest likelihood of coronary artery disease (<10%).
resultsOverall, 33% of patients had abnormal MPI of which 34% were women and 34% were obese. The mean effective doses and the percentage of exams involving only stress images were: (1) 3.53 ± 2.10 mSv and 37% in the overall population, (2) 4.83 ± 1.56 mSv and 5% in the subgroup with angiography and (3) 1.96 ± 1.52 mSv and 71 % in the low-probability subgroup. Sensitivity and global accuracy for identifying the 106 patients with coronary stenosis were 88 and 80%, respectively, while the normalcy rate was 97 %.
conclusionWhen planned with a low-dose stress-first protocol on a CZT camera, MPI provides high diagnostic performances and a dramatic reduction in patient radiation doses. This reduction is even greater in low-risk subgroups with high rates of normal stress images, thus allowing the mean radiation dose to be balanced against cardiac risk in targeted populations.
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