ArticleEukaryotic cell2015
MrSkn7 controls sporulation, cell wall integrity, autolysis, and virulence in Metarhizium robertsii.
Article in Eukaryotic cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- The chitinolytic enzymes from the entomopathogenic fungusFrontiers in fungal biology · 2026Review
- Skn7 Regulates Response to Oxidative Stress in the Opportunistic Fungi Scedosporium apiospermum.Mycopathologia · 2025Article
- Transcription Factors in Biocontrol Fungi.Journal of fungi (Basel, Switzerland) · 2025Review
- Fungal Stress Responses and the Importance of GPCRs.Journal of fungi (Basel, Switzerland) · 2025Review
- Histone deacetylase HDAC3 regulates ergosterol production for oxidative stress tolerance in the entomopathogenic and endophytic fungusmSystems · 2024Article
- A network of transcription factors in complex with a regulating cell cycle cyclin orchestrates fungal oxidative stress responses.BMC biology · 2024Article
- cAMP Signalling Pathway in Biocontrol Fungi.Current issues in molecular biology · 2022Review
- Host-Pathogen Interactions betweenJournal of fungi (Basel, Switzerland) · 2022Review
- The response regulator Skn7 of Aspergillus fumigatus is essential for the antifungal effect of fludioxonil.Scientific reports · 2021Article
- Identification of a key G-protein coupled receptor in mediating appressorium formation and fungal virulence against insects.Science China. Life sciences · 2021Article
- Roles of Three HSF Domain-Containing Proteins in Mediating Heat-Shock Protein Genes and Sustaining Asexual Cycle, Stress Tolerance, and Virulence inFrontiers in microbiology · 2018Article
- Article
- UvHOG1 is important for hyphal growth and stress responses in the rice false smut fungus Ustilaginoidea virens.Scientific reports · 2016Article
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5 authors.
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Abstract
Two-component signaling pathways generally include sensor histidine kinases and response regulators. We identified an ortholog of the response regulator protein Skn7 in the insect-pathogenic fungus Metarhizium robertsii, which we named MrSkn7. Gene deletion assays and functional characterizations indicated that MrSkn7 functions as a transcription factor. The MrSkn7 null mutant of M. robertsii lost the ability to sporulate and had defects in cell wall biosynthesis but was not sensitive to oxidative and osmotic stresses compared to the wild type. However, the mutant was able to produce spores under salt stress. Insect bioassays using these spores showed that the virulence of the mutant was significantly impaired compared to that of the wild type due to the failures to form the infection structure appressorium and evade host immunity. In particular, deletion of MrSkn7 triggered cell autolysis with typical features such as cell vacuolization, downregulation of repressor genes, and upregulation of autolysis-related genes such as extracellular chitinases and proteases. Promoter binding assays confirmed that MrSkn7 could directly or indirectly control different putative target genes. Taken together, the results of this study help us understand the functional divergence of Skn7 orthologs as well as the mechanisms underlying the development and control of virulence in insect-pathogenic fungi.
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