Trial reportJournal of dental research2015
Clinical and radiographic assessment of the efficacy of calcium silicate indirect pulp capping: a randomized controlled clinical trial.
Trial report in Journal of dental research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 45 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy of Calcium Silicate Pulp-capping; a Randomized Controlled Clinical Trial
Vital Root-resective Therapy in Furcation-involved Maxillary Molars
Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it, 144 citations in OpenAlex.
- Efficacy of different cavity liners compared to no cavity lining in managing deep caries in vital permanent teeth - a systematic review.Clinical oral investigations · 2025Pooled it
- Calcium silicate liner versus no liner in selective caries removal: a one-year randomized clinical trial.BMC oral health · 2026Trial
- Clinical and radiographic evaluation of Er: YAG laser-assisted direct pulp capping in permanent teeth with carious exposure.Lasers in medical science · 2025Trial
- Tomographic evaluation of direct pulp capping using a novel injectable treated dentin matrix hydrogel: a 2-year randomized controlled clinical trial.Clinical oral investigations · 2021Trial
- Comparison of indirect pulp treatment and iRoot BP Plus pulpotomy in primary teeth with extremely deep caries: a prospective randomized trial.Clinical oral investigations · 2021Trial
- Trial
- Evaluation of the efficacy of calcium silicate vs. glass ionomer cement indirect pulp capping and restoration assessment criteria: a randomised controlled clinical trial-2-year results.Clinical oral investigations · 2019Trial
- Clinical performance of lithium disilicate ceramic occlusal veneers for restoring cracked teeth: A 2- to 4-year prospective cohort study.Clinical oral investigations · 2026Article
- Physicochemical and remineralisation properties of calcium silicate and glass ionomer cements applied in simulated caries-affected dentine.European journal of oral sciences · 2026Article
- Clinical Outcomes of Immediate and Delayed Composite Restorations After Pulp Capping with Biodentine: A Systematic Literature Review.Journal of functional biomaterials · 2026Review
- Indirect Pulp Treatment for Deep Carious Lesions in Mature Permanent Teeth: A Preventive, Minimally Invasive Clinical Approach.Dentistry journal · 2026Article
- Decision-ready evidence for vital pulp therapy: a network meta-analysis of bioactive materials in mature permanent teeth.Frontiers in dental medicine · 2026Review
- Do Restorative Strategies and Delayed Restoration Improve the Bond Strength to Biodentine? In Vitro Study on Adhesive Restorations on a Calcium Silicate-Based Cement.The journal of adhesive dentistry · 2025Article
- Comparative evaluation of four different calcium-based medicaments as an indirect pulp capping agent: AnJournal of conservative dentistry and endodontics · 2025Article
- Indian Association of Conservative Dentistry and Endodontics consensus statement on deep caries management.Journal of conservative dentistry and endodontics · 2025Article
- Vital pulp therapies in permanent teeth: what, when, where, who, why and how?British dental journal · 2025Review
- Endodontic assessment, complexity, diagnosis and treatment planning.British dental journal · 2025Article
- Expert consensus on pulpotomy in the management of mature permanent teeth with pulpitis.International journal of oral science · 2025Review
- A systematic review and meta-analysis evaluating the success of different protective liners after performing selective caries removal.Biomaterial investigations in dentistry · 2025Review
- Clinical and radiographic success of pulpotomy and pulpectomy in primary and permanent teeth: a Systematic Review and Meta-Analysis.Journal of clinical and experimental dentistry · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
The aims of this study were to assess the effectiveness of calcium silicate cement (Biodentine) versus glass ionomer cement (GIC; control group) as indirect pulp capping materials in patients with reversible pulpitis and to compare the effectiveness of cone beam computed tomography (CBCT) versus periapical (PA) radiographs in detecting PA changes at baseline (T0) and at 12 mo (T12) postoperatively. Seventy-two restorations (36 Biodentine, 36 Fuji IX) were placed randomly in 53 patients. CBCT/PA radiographs were taken at T0 and T12. Two calibrated examiners assessed the presence/absence and increase/decrease in the size of existing PA radiolucencies under standardized conditions. The Kappa coefficient evaluated statistically the effectiveness of CBCT versus PA radiographs in detecting PA changes. Chi-square/Mann-Whitney tests were used to evaluate the association between PA changes in CBCT with various clinical measures. Significance was predetermined at α = 0.05. Clinical success rates for Biodentine and Fuji IX GIC were 83.3%. CBCT was significantly more effective in detecting PA radiolucencies compared with radiographs (P = 0.0069). Of the teeth, 65.4% and 90.4% were deemed healthy using CBCT and PA radiographs, respectively, at T12. Healing/healed rates were 17.3%/0%, while new/progressed radiolucency were 30.8%/9.6% with CBCT/PA radiographs, respectively. Seventy-one percent of healed lesions had received Biodentine; 88% of new/progressed lesions received Fuji IX GIC. Teeth presenting with an initial CBCT PA lesion had a failure rate of 63%, whereas teeth with no initial lesion had a failure rate of 16%. Although no statistically significant difference was detected in the clinical efficacy of Biodentine/Fuji IX when used as indirect pulp capping materials in patients with reversible pulpitis, CBCT showed a significant difference in that most healed CBCT lesions had received Biodentine while most that did not heal received Fuji IX. Longer-term follow-up is needed to establish their effect on the healing dynamics of PA tissues (ClinicalTrials.gov NCT02201641).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.