ArticleJournal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases2015
Presence of gout is associated with increased prevalence and severity of knee osteoarthritis among older men: results of a pilot study.
Article in Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- 2024 Update of Chinese Guidelines for Management of Hyperuricemia and Gout Part II: Recommendations for Patients With Common Comorbidities.International journal of rheumatic diseases · 2025Guideline
- Prevalence and Severity of Spinal Osteoarthritis in Gout Patients Versus Non-Gout Controls.Gout, urate, and crystal deposition disease · 2026Article
- The association between the uric acid-to-high-density lipoprotein cholesterol ratio and osteoarthritis risk in U.S. adults: a cross-sectional study based on NHANES 1999-2016.Lipids in health and disease · 2025Article
- The impact of uric acid on musculoskeletal diseases: clinical associations and underlying mechanisms.Frontiers in endocrinology · 2025Review
- Gout and Hyperuricemia: A Narrative Review of Their Comorbidities and Clinical Implications.Journal of clinical medicine · 2024Review
- Associations of Changes in Knee Hyaline Cartilage Composition Measured With Dual-Energy Computed Tomography in Gout, Aging and Osteoarthritis.Cartilage · 2024Article
- ULTRASONOGRAPHIC EVALUATION OF FEMORAL CARTILAGE THICKNESS IN PARTICIPANTS WITH ASYMPTOMATIC HYPERURICEMIA: A CASE-CONTROL STUDY.Acta clinica Croatica · 2023Article
- Increase in NO causes osteoarthritis and chondrocyte apoptosis and chondrocyte ERK plays a protective role in the process.Molecular biology reports · 2021Article
- Which factors predict discordance between a patient and physician on a gout flare?Rheumatology (Oxford, England) · 2021Article
- Increased risk of knee osteoarthritis in patients using oral N-acetylcysteine: a nationwide cohort study.BMC musculoskeletal disorders · 2020Article
- The coexistence of gout in ankylosing spondylitis patients: a case control study.Rheumatology international · 2020Article
- Limited Knee-Joint Range of Motion in Patients With Tophaceous Gout Improved With Medical Treatment: A 18-Months Follow Up.Frontiers in medicine · 2020Article
- Urate and osteoarthritis: Evidence for a reciprocal relationship.Joint bone spine · 2019Review
- The association between asymptomatic hyperuricemia and knee osteoarthritis: data from the third National Health and Nutrition Examination Survey.Osteoarthritis and cartilage · 2019Article
- Article
- Urate-lowering treatment and risk of total joint replacement in patients with gout.Rheumatology (Oxford, England) · 2018Article
- Crystal arthritis: Crystallizing our ideas about gout and osteoarthritis.Nature reviews. Rheumatology · 2017Article
- Gout and risk of knee replacement for severe knee osteoarthritis in the Singapore Chinese Health Study.Osteoarthritis and cartilage · 2017Article
- Serum Urate Levels Predict Joint Space Narrowing in Non-Gout Patients With Medial Knee Osteoarthritis.Arthritis & rheumatology (Hoboken, N.J.) · 2017Article
- Association Between Gout and Aortic Stenosis.The American journal of medicine · 2017Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundGout and osteoarthritis (OA) are the most prevalent arthritides, but their relationship is neither well established nor well understood.
objectivesWe assessed whether a diagnosis of gout or asymptomatic hyperuricemia (AH) is associated with increased prevalence/severity of knee OA.
methodsOne hundred nineteen male patients aged 55 to 85 years were sequentially enrolled from the primary care clinics of an urban Veterans Affairs hospital, assessed and categorized into 3 groups: gout (American College of Rheumatology Classification Criteria), AH (serum urate ≥6.8 mg/dL, no gout), and control (serum urate <6.8 mg/dL, no gout). Twenty-five patients from each group subsequently underwent formal assessment of knee OA presence and severity (American College of Rheumatology Clinical/Radiographic Criteria, Kellgren-Lawrence grade). Musculoskeletal ultrasound was used to detect monosodium urate deposition at the knees and first metatarsophalangeal joints.
resultsThe study showed 68.0% of gout, 52.0% of AH, and 28.0% of age-matched control subjects had knee OA (gout vs control, P = 0.017). Odds ratio for knee OA in gout versus control subjects was 5.46 prior to and 3.80 after adjusting for body mass index. Gout subjects also had higher Kellgren-Lawrence grades than did the control subjects (P = 0.001). Subjects with sonographically detected monosodium urate crystal deposition on cartilage were more likely to have OA than those without (60.0 vs 27.5%, P = 0.037), with crystal deposition at the first metatarsophalangeal joints correlating most closely with OA knee involvement.
conclusionsKnee OA was more prevalent in gout patients versus control subjects and intermediate in AH. Knee OA was more severe in gout patients versus control subjects.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.