ArticleClinical journal of the American Society of Nephrology : CJASN2015
Mineral metabolism in European children living with a renal transplant: a European society for paediatric nephrology/european renal association-European dialysis and transplant association registry study.
Article in Clinical journal of the American Society of Nephrology : CJASN, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 24 citations in OpenAlex.
- Diagnosis and management of mineral and bone disorders in paediatric kidney transplant recipients: a position statement from the European Society for Paediatric Nephrology.Pediatric nephrology (Berlin, Germany) · 2026Review
- Persistent hyperparathyroidism after kidney transplantation in children.Renal failure · 2025Article
- Prognostic Significance of Hypophosphatemia in Kidney Transplant Patients: A Systematic Review and Meta-Analysis.Journal of evidence-based medicine · 2025Article
- Hyperparathyroidism Is an Independent Risk Factor for Allograft Dysfunction in Pediatric Kidney Transplantation.Kidney international reports · 2023Article
- Epidemiology of pediatric chronic kidney disease/kidney failure: learning from registries and cohort studies.Pediatric nephrology (Berlin, Germany) · 2022Review
- Body mass index is associated with hyperparathyroidism in pediatric kidney transplant recipients.Pediatric nephrology (Berlin, Germany) · 2021Article
- Assessing bone mineralisation in children with chronic kidney disease: what clinical and research tools are available?Pediatric nephrology (Berlin, Germany) · 2020Review
- C-type natriuretic peptide attenuates renal osteodystrophy through inhibition of FGF-23/MAPK signaling.Experimental & molecular medicine · 2019Article
- Long-Term Outcomes of Kidney Transplantation in Children.Pediatric clinics of North America · 2019Review
- Mineral and Bone Disorders After Kidney Transplantation.Frontiers in medicine · 2018Review
- Article
- Factors associated with cardiovascular target organ damage in children after renal transplantation.Pediatric nephrology (Berlin, Germany) · 2017Article
- Lessons learned from the ESPN/ERA-EDTA Registry.Pediatric nephrology (Berlin, Germany) · 2016Review
- The Kidney-Vascular-Bone Axis in the Chronic Kidney Disease-Mineral Bone Disorder.Transplantation · 2016Review
- Phosphate and FGF-23 homeostasis after kidney transplantation.Nature reviews. Nephrology · 2015Review
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Authors and funding
23 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesData on mineral metabolism in pediatric renal transplant recipients largely arise from small single-center studies. In adult patients, abnormal mineral levels are related to a higher risk of graft failure. This study used data from the European Society for Paediatric Nephrology/European Renal Association-European Dialysis and Transplant Association Registry to study the prevalence and potential determinants of mineral abnormalities, as well as the predictive value of a disturbed mineral level on graft survival in a large cohort of European pediatric renal transplant recipients. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: This study included 1237 children (0-17 years) from 10 European countries, who had serum calcium, phosphorus, and parathyroid hormone measurements from 2000 onward. Abnormalities of mineral metabolism were defined according to European guidelines on prevention and treatment of renal osteodystrophy in children on chronic renal failure.
resultsAbnormal serum phosphorus levels were observed in 25% (14% hypophosphatemia and 11% hyperphosphatemia), altered serum calcium in 30% (19% hypocalcemia, 11% hypercalcemia), and hyperparathyroidism in 41% of the patients. A longer time since transplantation was associated with a lower risk of having mineral levels above target range. Serum phosphorus levels were inversely associated with eGFR, and levels above the recommended targets were associated with a higher risk of graft failure independently of eGFR.
conclusionsAbnormalities in mineral metabolism are common after pediatric renal transplantation in Europe and are associated with graft dysfunction.
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