ArticlePloS one2015
Association between appendectomy and subsequent colorectal cancer development: an Asian population study.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 4 of them syntheses that pooled it.
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Who cites it
49 citing papers in PubMed, 4 syntheses or guidelines pooled it, 104 citations in OpenAlex.
- Risk of colorectal cancer and adenoma after an appendectomy: results from three large prospective cohort studies and meta-analysis.Cancer causes & control : CCC · 2024Pooled it
- No genetic causality between appendectomy and gastrointestinal cancers: a Mendelian randomization study and meta-analysis in European population.Scientific reports · 2024Pooled it
- Comparison of the efficacy and safety of antibiotic treatment and appendectomy for acute uncomplicated appendicitis: a systematic review and meta-analysis.BMC surgery · 2023Pooled it
- Methods of conservative antibiotic treatment of acute uncomplicated appendicitis: A systematic review.The journal of trauma and acute care surgery · 2019Pooled it
- Causality between appendiceal disease and cancers of the digestive system: A Mendelian randomization study.Medicine · 2026Article
- Submarine medicine as an analog for spaceflight: a review of acute medical care.NPJ microgravity · 2026Review
- Appendectomy and Risk of Nonyphoidal Salmonella Infection in Children.JAMA network open · 2026Article
- Dissecting the potential impact of appendectomy on colorectal cancer through metabolites and inflammatory proteins: a Mendelian randomization study.Archives of medical science : AMS · 2026Article
- Appendectomy and colorectal cancer: a mini review from the perspective of gut microbiota and mucosal immunity.Frontiers in cellular and infection microbiology · 2026Review
- Appendicitis.Nature reviews. Disease primers · 2025Review
- Cholangioscope-Assisted ERAT: The Light at the End of a Blind Tunnel?Digestive diseases and sciences · 2025Article
- Appendectomy and Long-term Colorectal Cancer Incidence, Overall and by Tumor Fusobacterium nucleatum Status.Annals of surgery · 2025Article
- The association between appendectomy and increased invasion of ascending colon cancer: a retrospective study involving 880 patients.World journal of surgical oncology · 2025Article
- Exploring the Immunological Role of the Microbial Composition of the Appendix and the Associated Risks of Appendectomies.Journal of personalized medicine · 2025Review
- Endoscopic retrograde appendicitis therapy for management of chronic fecalith appendicitis.Surgical endoscopy · 2025Article
- Colorectal screening following appendectomy in adult patients: a systematic review.Annals of coloproctology · 2024Review
- The association of appendectomy with prognosis and tumor-associated macrophages in patients with colorectal cancer.iScience · 2024Article
- Prior Appendicectomy and Gut Microbiota Re-Establishment in Adults after Bowel Preparation and Colonoscopy.Biomedicines · 2024Article
- Is appendoscope a new option for the treatment of acute appendicitis?World journal of gastroenterology · 2024Review
- Elevated Colon Cancer Rates Linked to Prior Appendicitis: A Retrospective Cohort Study Based on Data from German General Practices.Journal of clinical medicine · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe appendix may modulate colon microbiota and bowel inflammation. We investigated whether appendectomy alters colorectal cancer risk.
methodsWe identified a cohort of 75,979 patients who underwent appendectomy between 1997 and 1999 based on the insurance claims of Taiwan. A comparison cohort of 303,640 persons without appendectomy was selected randomly, frequency matched by age, sex, comorbidity and entry year was also selected. We monitored subsequent colorectal cancer development in both cohorts.
resultsThe overall colorectal cancer incidence was 14% higher in the appendectomy patients than in the comparison cohort (p <0.05): the highest incidence was observed for rectal cancer, and the lowest incidence was observed for cancer of the cecum-ascending colon for both cohorts. Men were at higher risk than women. Subjects ≥ 60 years had an HR of 12.8 compared to those <60 years. The incidence of colorectal cancer was much higher in 1.5-3.5 years post appendectomy follow-up than for the comparisons (HR of 2.13). Patients who received an incidental appendectomy had an HR of 2.90 when compared to the comparisons.
conclusionsResults of our study suggest that appendectomy in patients with appendicitis is likely associated with the development of colorectal cancer in the post-surgery period.
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