ArticleJournal of clinical neurophysiology : official publication of the American Electroencephalographic Society2015
Periodic Lateralized Epileptiform Discharges and Afterdischarges: Common Dynamic Mechanisms.
Article in Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- EEG patterns in each phase of hemiplegic migraine: a systematic review and pooled prevalence meta-analysis.The journal of headache and pain · 2025Pooled it
- Periodic discharges in veterinary electroencephalography-A visual review.Frontiers in veterinary science · 2023Review
- Stimulating native seizures with neural resonance: a new approach to localize the seizure onset zone.Brain : a journal of neurology · 2022Article
- Hemodynamic Changes Associated with Lateralized Periodic Discharges: A Near-Infrared Spectroscopy and Continuous EEG Study.Neurocritical care · 2021Article
- Can Spectral Power Be Used as a Candidate Seizure Marker of the Periodic Discharges Pattern?Frontiers in neurology · 2021Article
- The Ictal-Interictal Continuum: To Treat or Not to Treat (and How)?Neurocritical care · 2018Review
- Periodic Lateralized Epileptiform Discharges can Survive Anesthesia and Result in Asymmetric Drug-induced Burst Suppression.Neurology international · 2017Article
- A unified statistical model for the human electrocorticogram.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2016Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
purposeNo neurophysiological hypothesis currently exists addressing how and why periodic lateralized epileptiform discharges (PLEDs) arise in certain types of brain disease. Based on spectral analysis of clinical scalp EEG traces, the authors formulated a general mechanism for the emergence of PLEDs.
methodsThe authors retrospectively analyzed spectra of PLED time series and control EEG segments from the opposite hemisphere in 25 hospitalized neurological patients. The observations led to the development of a phenomenological model for PLED emergence.
resultsSimilar to that observed in our previous work with afterdischarges, an analytic relationship is found between the spectrum of the baseline EEG and the PLED EEG, characterized by "condensation" of the main baseline spectral cluster, with variable inclusion of higher harmonics of the condensate.
conclusionsPeriodic lateralized epileptiform discharges may arise by synchronization of preexisting local field potentials, through a variable combination of enhancement of excitatory neurotransmission and inactivation of inhibitory neurotransmission provoked by the PLED-associated disease process. Higher harmonics in the PLED spectrum may arise by recurrent feedback, possibly from entrained single units. A mechanism is suggested for PLED emergence in certain diseased brain states and the association of PLEDs with EEG seizures. The framework is a spatially extended version of that, which the authors proposed, underlies afterdischarge and analogous to the cooperative behavior seen in a variety of natural multi-oscillator systems.
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