ArticlePloS one2015
Positive influence of being overweight/obese on long term survival in patients hospitalised due to acute heart failure.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 22 citations in OpenAlex.
- Association between body mass index and clinical outcomes in patients with acute myocardial infarction and reduced systolic function: Analysis of PARADISE-MI trial data.European journal of heart failure · 2025Trial
- Cardiogenic Shock: Outcome Patterns Across the Body Mass Spectrum and Renal Vulnerability.Cardiology · 2026Article
- Obesity Paradox: Fact or Fiction?Current obesity reports · 2023Review
- The Relationship Between Body Mass Index and In-hospital Survival in Patients Admitted With Acute Heart Failure.Frontiers in cardiovascular medicine · 2022Article
- The Impact of Obesity on Renal Trauma Outcome: An Analysis of the National Trauma Data Bank from 2013 to 2016.World journal of surgery · 2021Article
- Obesity paradox and heart failure.Eating and weight disorders : EWD · 2021Review
- The Obesity Paradox in the Trauma Patient: Normal May not Be Better.World journal of surgery · 2020Article
- Long-Term Weight Gain Associated With High Omentin Levels at Hospital Discharge Improves Prognosis of Patients Following Acute Heart Failure.Journal of cardiovascular translational research · 2019Observational
- Impact of Body Mass Index on Activities of Daily Living in Inpatients with Acute Heart Failure.The journal of nutrition, health & aging · 2019Article
- Beneficial effects of leptin treatment in a setting of cardiac dysfunction induced by transverse aortic constriction in mouse.The Journal of physiology · 2017Article
- Diagnostic performance of body mass index to identify adiposity in women.European journal of clinical nutrition · 2016Article
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Authors and funding
32 authors at 11 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundObesity is clearly associated with increased morbidity and mortality rates. However, in patients with acute heart failure (AHF), an increased BMI could represent a protective marker. Studies evaluating the "obesity paradox" on a large cohort with long-term follow-up are lacking.
methodsUsing the AHEAD database (a Czech multi-centre database of patients hospitalised due to AHF), 5057 patients were evaluated; patients with a BMI <18.5 kg/m2 were excluded. All-cause mortality was compared between groups with a BMI of 18.5-25 kg/m2 and with BMI >25 kg/m2. Data were adjusted by a propensity score for 11 parameters.
resultsIn the balanced groups, the difference in 30-day mortality was not significant. The long-term mortality of patients with normal weight was higher than for those who were overweight/obese (HR, 1.36; 95% CI, 1.26-1.48; p<0.001)). In the balanced dataset, the pattern was similar (1.22; 1.09-1.39; p<0.001). A similar result was found in the balanced dataset of a subgroup of patients with de novo AHF (1.30; 1.11-1.52; p = 0.001), but only a trend in a balanced dataset of patients with acute decompensated heart failure.
conclusionThese data suggest significantly lower long-term mortality in overweight/obese patients with AHF. The results suggest that at present there is no evidence for weight reduction in overweight/obese patients with heart failure, and emphasize the importance of prevention of cardiac cachexia.
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