SynthesisNature communications2015
Genome-wide association study identifies peanut allergy-specific loci and evidence of epigenetic mediation in US children.
Open access · goldAbstract readMeta-Analysis
In one paragraph
Synthesis in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 110 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
110citing papers in PubMed, 2 pooled it
19.4field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
110 citing papers in PubMed, 2 syntheses or guidelines pooled it, 242 citations in OpenAlex.
- Nutrition and Gut Microbiome in the Prevention of Food Allergy.Nutrients · 2025Pooled it
- Genome-Wide Association Study Reveals a Causal Relationship Between Allergic Rhinitis and Hazelnut Allergy.Allergy · 2025Pooled it
- Immunonutritional effects elicited by a novel multicomponent food supplement in children with cow's milk allergy: results from a randomized, placebo-controlled trial.Frontiers in allergy · 2026Trial
- HLA alleles and sustained peanut consumption promote IgG4 responses in subjects protected from peanut allergy.The Journal of clinical investigation · 2022Trial
- Transcriptional changes in peanut-specific CD4+ T cells over the course of oral immunotherapy.Clinical immunology (Orlando, Fla.) · 2020Trial
- Trial
- The Michigan Sibling Immunity Birth Study (M-SIBS): Study design protocol for a unique food allergy birth cohort.The journal of allergy and clinical immunology. Global · 2026Article
- Epigenetic insights into food allergy: The potential role of DNA methylation in diagnosis and management.The World Allergy Organization journal · 2026Review
- Immune-induced TCR-like antibodies regulate specific T cell response in mice.Nature communications · 2026Article
- Rising Tide of Crustacean Allergies in East Asia: a Comprehensive Review of Genetic Insights and Implications for Early Evaluation of Health Risks.Clinical reviews in allergy & immunology · 2026Review
- Gut mucosal immune responses - Implications for celiac disease and food allergy.Seminars in immunology · 2025Review
- HLA variation associated with peanut allergy and anaphylaxis among non-Hispanic Black individuals.The journal of allergy and clinical immunology. Global · 2025Article
- Update on the genetics of allergic diseases.The Journal of allergy and clinical immunology · 2025Review
- Integrating Exposures and Multi-Omics in the Boston Birth Cohort to Elucidate Immune Development across the Life Course: Rationale and Study Design.Precision nutrition · 2025Article
- Differential DNA methylation in infants with IgE- and non-IgE-mediated cow's milk allergy and its association with acquired tolerance.Frontiers in immunology · 2025Article
- Scientific developments in understanding food allergy prevention, diagnosis, and treatment.Frontiers in immunology · 2025Review
- Review
- Early allergen introduction overrides allergy predisposition in offspring of horses withFrontiers in immunology · 2025Article
- A mutation in Themis contributes to anaphylaxis severity following oral peanut challenge in CC027 mice.The Journal of allergy and clinical immunology · 2024Article
- A genetic-epigenetic interplay at 1q21.1 locus underlies CHD1L-mediated vulnerability to primary progressive multiple sclerosis.Nature communications · 2024Article
50 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
32 authors at 10 institutions in 3 countries.
Xiumei HongDepartment of Population, Family and Reproductive Health, Center on the Early Life Origins of Disease, Johns Hopkins University Bloomberg School of Public Health, 615 North Wolfe Street, E4132, Baltimore, Maryland 21205, USA.
Ke HaoDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Christine Ladd-AcostaDepartment of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA.
Kasper D Hansen1] Department of Biostatistics, Johns Hopkins University Bloomberg School of Public Health Baltimore, Baltimore, Maryland 21205, USA [2] McKusick-Nathans Insitute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
Hui-Ju Tsai1] Mary Ann and J. Milburn Smith Child Health Research Program, Department of Pediatrics, Northwestern University Feinberg School of Medicine and Stanley Manne Children's Research Institute, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois 60611, USA [2] Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Zhunan 35053, Taiwan [3] Department of Public Health, China Medical University, Taichung 40402, Taiwan.
Xin Liu1] Mary Ann and J. Milburn Smith Child Health Research Program, Department of Pediatrics, Northwestern University Feinberg School of Medicine and Stanley Manne Children's Research Institute, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois 60611, USA [2] Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.
Xin XuGuangdong Provincial Institute of Nephrology, Southern Medical University, Guangzhou 510515, China.
Timothy A ThorntonDepartment of Biostatistics, University of Washington, Seattle, Washington 98195, USA.
Deanna CarusoDepartment of Population, Family and Reproductive Health, Center on the Early Life Origins of Disease, Johns Hopkins University Bloomberg School of Public Health, 615 North Wolfe Street, E4132, Baltimore, Maryland 21205, USA.
Corinne A Keet1] Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA [2] Division of Pediatric Allergy and Immunology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.
Yifei SunDepartment of Biostatistics, Johns Hopkins University Bloomberg School of Public Health Baltimore, Baltimore, Maryland 21205, USA.
Guoying WangDepartment of Population, Family and Reproductive Health, Center on the Early Life Origins of Disease, Johns Hopkins University Bloomberg School of Public Health, 615 North Wolfe Street, E4132, Baltimore, Maryland 21205, USA.
Wei Luo1] Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA [2] College of Computer Science and Technology, Huaqiao University, Xiamen 361021, China.
Rajesh KumarDivision of Allergy and Immunology, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois 60611, USA.
Ramsay FuleihanDivision of Allergy and Immunology, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois 60611, USA.
Anne Marie SinghDepartment of Pediatrics and Medicine, Ann and Robert H. Lurie Children's Hospital of Chicago, Northwestern Feinberg School of Medicine, Chicago, Illinois 61611, USA.
Jennifer S Kim1] Division of Allergy and Immunology, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois 60611, USA [2] NorthShore University HealthSystem, Evanston, Illinois 60201, USA.
Rachel E Story1] Division of Allergy and Immunology, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois 60611, USA [2] NorthShore University Health Systems, Pritzker School of Medicine, University of Chicago, Chicago, Illinois 60637, USA.
Ruchi S GuptaMary Ann and J. Milburn Smith Child Health Research Program, Department of Pediatrics, Northwestern University Feinberg School of Medicine and Stanley Manne Children's Research Institute, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois 60611, USA.
Peisong GaoDivision of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA.
Zhu ChenDepartment of Population, Family and Reproductive Health, Center on the Early Life Origins of Disease, Johns Hopkins University Bloomberg School of Public Health, 615 North Wolfe Street, E4132, Baltimore, Maryland 21205, USA.
Sheila O WalkerDepartment of Population, Family and Reproductive Health, Center on the Early Life Origins of Disease, Johns Hopkins University Bloomberg School of Public Health, 615 North Wolfe Street, E4132, Baltimore, Maryland 21205, USA.
Tami R BartellMary Ann and J. Milburn Smith Child Health Research Program, Department of Pediatrics, Northwestern University Feinberg School of Medicine and Stanley Manne Children's Research Institute, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois 60611, USA.
Terri H BeatyDepartment of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA.
M Daniele FallinDepartment of Mental Health, Wendy Klag Center for Autism and Developmental Disabilities, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA.
Robert SchleimerDivision of Allergy-Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.
Patrick G HoltTelethon Kids Institute, University of Western Australia; Perth and Queensland Children's Medical Research Institute, University of Queensland, Brisbane, Queensland 4029, Australia.
Kari Christine NadeauDivision of Allergy, Immunology and Rheumatology, Stanford University School of Medicine, Stanford, California 94305, USA.
Robert A WoodDivision of Pediatric Allergy and Immunology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.
Jacqueline A PongracicDivision of Allergy and Immunology, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois 60611, USA.
Daniel E WeeksDepartments of Human Genetics and Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA.
Xiaobin Wang1] Department of Population, Family and Reproductive Health, Center on the Early Life Origins of Disease, Johns Hopkins University Bloomberg School of Public Health, 615 North Wolfe Street, E4132, Baltimore, Maryland 21205, USA [2] Division of General Pediatrics and Adolescent Medicine, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.
Johns Hopkins University · USLurie Children's Hospital · USIcahn School of Medicine at Mount Sinai · USJohns Hopkins Medicine · USNorthwestern University · USSouthern Medical University · CNStanford University · USUniversity of Pittsburgh · USUniversity of Washington · USUniversity of Western Australia · AU
Funding
Statistical Methods for X-Chromosome Genetic DataP01GM099568 · NIGMS · UNIVERSITY OF WASHINGTON · PI THORNTON, TIMOTHY ALVIN · 2012 to 2016
$7.3MResearch Infrastructure for the Hopkins Population CenterR24HD042854 · NICHD · JOHNS HOPKINS UNIVERSITY · PI HAO, LINGXIN · 2003 to 2017
$5.1MGlucocorticosteroid Action In Inflammatory DiseaseR37HL068546 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SCHLEIMER, ROBERT P · 2009 to 2018
$3.5MPost Genome-Wide Association Study of Food AllergyU01AI090727 · NIAID · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI WANG, XIAOBIN · 2010 to 2014
$2.3MSensitization to Cockroach Allergen: Immune Regulation and Genetic DeterminantsR01ES021739 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI GAO, PEISONG · 2013 to 2017
$1.8MGenome-Wide Association Study of Food AllergyR56AI080627 · NIAID · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI WANG, XIAOBIN · 2009 to 2010
$1.3MS. aureus and Regulatory T cells in the Failure of Oral ToleranceK23AI100995 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI SINGH, ANNE MARIE · 2013 to 2017
$689kGenetic and Environmental Determinants of Food AllergyK23AI103187 · NIAID · JOHNS HOPKINS UNIVERSITY · PI KEET, CORINNE · 2012 to 2016
$684kStatistical Methods for Cancer Genetic Association Studies with Hidden PopulationK01CA148958 · NCI · UNIVERSITY OF WASHINGTON · PI THORNTON, TIMOTHY ALVIN · 2010 to 2014
$682kEpigenome Association Study of Food AllergyR21AI088609 · NIAID · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI WANG, XIAOBIN · 2010 to 2011
$409kNCI NIH HHS K01 CA148958NHLBI NIH HHS R37 HL068546NIAID NIH HHS K23 AI100995NIAID NIH HHS K23 AI103187NIAID NIH HHS R21 AI088609NIAID NIH HHS R21AI088609NIAID NIH HHS R56 AI080627NIAID NIH HHS R56AI080627NIAID NIH HHS U01 AI090727NIAID NIH HHS U01AI090727NICHD NIH HHS R24 HD042854NIEHS NIH HHS R01 ES021739NIGMS NIH HHS P01 GM099568
Abstract
Food allergy (FA) affects 2%-10% of US children and is a growing clinical and public health problem. Here we conduct the first genome-wide association study of well-defined FA, including specific subtypes (peanut, milk and egg) in 2,759 US participants (1,315 children and 1,444 parents) from the Chicago Food Allergy Study, and identify peanut allergy (PA)-specific loci in the HLA-DR and -DQ gene region at 6p21.32, tagged by rs7192 (P=5.5 × 10(-8)) and rs9275596 (P=6.8 × 10(-10)), in 2,197 participants of European ancestry. We replicate these associations in an independent sample of European ancestry. These associations are further supported by meta-analyses across the discovery and replication samples. Both single-nucleotide polymorphisms (SNPs) are associated with differential DNA methylation levels at multiple CpG sites (P<5 × 10(-8)), and differential DNA methylation of the HLA-DQB1 and HLA-DRB1 genes partially mediate the identified SNP-PA associations. This study suggests that the HLA-DR and -DQ gene region probably poses significant genetic risk for PA.
Indexed as
Genome-Wide Association StudyAdolescentChildChild, PreschoolDNA MethylationEpigenesis, GeneticFemaleGenetic Predisposition to DiseaseHLA-DQ AntigensHLA-DR AntigensHumansInfantMalePeanut HypersensitivityPhenotypePolymorphism, Single NucleotideHLA-DQ AntigensHLA-DR Antigens
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