Trial reportThe Journal of clinical endocrinology and metabolism2015
Preconception low dose aspirin and time to pregnancy: findings from the effects of aspirin in gestation and reproduction randomized trial.
Trial report in The Journal of clinical endocrinology and metabolism, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Aspirin or heparin or both for improving pregnancy outcomes in women with persistent antiphospholipid antibodies and recurrent pregnancy loss.The Cochrane database of systematic reviews · 2020Pooled it
- Antiplatelet agents for preventing pre-eclampsia and its complications.The Cochrane database of systematic reviews · 2019Pooled it
- Use of Machine Learning to Estimate the Per-Protocol Effect of Low-Dose Aspirin on Pregnancy Outcomes: A Secondary Analysis of a Randomized Clinical Trial.JAMA network open · 2022Trial
- The Effect of Preconception-Initiated Low-Dose Aspirin on Human Chorionic Gonadotropin-Detected Pregnancy, Pregnancy Loss, and Live Birth : Per Protocol Analysis of a Randomized Trial.Annals of internal medicine · 2021Trial
- A prospective study of physical activity and fecundability in women with a history of pregnancy loss.Human reproduction (Oxford, England) · 2018Trial
- Association of testosterone and antimüllerian hormone with time to pregnancy and pregnancy loss in fecund women attempting pregnancy.Fertility and sterility · 2018Trial
- C-Reactive protein in relation to fecundability and anovulation among eumenorrheic women.Fertility and sterility · 2018Trial
- Low-Dose Aspirin and Sporadic Anovulation in the EAGeR Randomized Trial.The Journal of clinical endocrinology and metabolism · 2017Trial
- Previous pregnancy loss and gestational cardiovascular health: A prospective cohort of nulliparous women.Frontiers in public health · 2023Article
- Prospectively assessed perceived stress associated with early pregnancy losses among women with history of pregnancy loss.Human reproduction (Oxford, England) · 2022Article
- Feasibility of leveraging menstrual cycle tracking apps for preconception research recruitment.Frontiers in reproductive health · 2022Article
- AIPW: An R Package for Augmented Inverse Probability-Weighted Estimation of Average Causal Effects.American journal of epidemiology · 2021Article
- Platelet activation and placenta-mediated adverse pregnancy outcomes: an ancillary study to the Effects of Aspirin in Gestation and Reproduction trial.American journal of obstetrics and gynecology · 2020Article
- Analgesic use at ovulation and implantation and human fertility.American journal of obstetrics and gynecology · 2020Article
- Family history of autoimmune disease in relation to time-to-pregnancy, pregnancy loss, and live birth rate.Journal of translational autoimmunity · 2020Article
- Preconception Perceived Stress Is Associated with Reproductive Hormone Levels and Longer Time to Pregnancy.Epidemiology (Cambridge, Mass.) · 2019Article
- Preconception Leptin and Fecundability, Pregnancy, and Live Birth Among Women With a History of Pregnancy Loss.Journal of the Endocrine Society · 2019Article
- Cardiovascular disease family history and risk of pregnancy loss.Annals of epidemiology · 2019Observational
- The role of aspirin and inflammation on reproduction: the EAGeR trialCanadian journal of physiology and pharmacology · 2019Review
- Shorter Time to Pregnancy With Increasing Preconception Carotene Concentrations Among Women With 1-2 Previous Pregnancy Losses.American journal of epidemiology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 8 institutions in 2 countries.
Funding
Abstract
objectiveThe objective was to determine the effect of preconception-initiated daily low-dose aspirin (LDA; 81 mg/day) treatment on time to pregnancy in women with a history of pregnancy loss.
designThis was a multicenter, block-randomized, double-blind, placebo-controlled trial. Participants were block-randomized by center and eligibility stratum.
settingThe study was conducted at four U.S.A. medical centers (2007-2012).
participantsParticipants women aged 18-40 years actively attempting pregnancy, stratified by eligibility criteria: the "original" stratum, women with one loss <20 weeks' gestation during the previous year; and the "expanded" stratum, women with one or two previous losses of any gestational age regardless of time since loss.
interventionDaily LDA was compared with matching placebo for up to six menstrual cycles of attempting pregnancy.
main outcome measureTime to hCG detected pregnancy and clinically confirmed pregnancy, analyzed by intention-to-treat, was measured.
resultsOf the 1228 women randomly assigned to LDA (n = 615) or placebo (n = 613), 410 (67%) women receiving LDA achieved pregnancy compared to 382 (63%) receiving placebo, corresponding to a fecundability odds ratio (FOR) of 1.14 (95% CI: 0.97, 1.33). Among women in the original stratum (n = 541), LDA was associated with increased fecundability compared to placebo (FOR: 1.28; 95%CI: 1.02, 1.62).
conclusionsPreconception-initiated LDA treatment resulted in a nonsignificant increase in fecundability of 14% in women with a history of 1-2 pregnancy losses, and a significant increase of 28% in women with a history of only one pregnancy loss of <20 weeks' gestation in the preceding year. Preconception-initiated LDA may increase fecundability in certain women with a recent early pregnancy loss.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.