Evidence map›Paper›PMID 25710532›Full record

ReviewDevelopmental cell2015

Subcellular patterning: axonal domains with specialized structure and function.

Elizabeth A Normand, Matthew N Rasband

Abstract readReview
In one paragraph

Review in Developmental cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Neuronal sub-compartmentalization: a strategy to optimize neuronal function.Biological reviews of the Cambridge Philosophical Society · 2019
    Review
  7. The Axon Initial Segment: An Updated Viewpoint.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018
    Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Activity-dependent regulation of excitable axonal domains.The journal of physiological sciences : JPS · 2016
    Review
  15. Review
  16. Review
  17. Glia in mammalian development and disease.Development (Cambridge, England) · 2015
    Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Elizabeth A NormandDepartment of Neuroscience Baylor College of Medicine, Houston, TX 77030, USA.
Matthew N RasbandDepartment of Neuroscience Baylor College of Medicine, Houston, TX 77030, USA. Electronic address: rasband@bcm.edu.

Funding

Steps towards a paternal gene activation therapy for Angelman syndromeU54HD083092 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI NELSON, DAVID LOREN, NEUL, JEFFREY L · 2014 to 2019
$7.8M
Neuroglial Interactions at the Node of RanvierR01NS044916 · NINDS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI RASBAND, MATTHEW N · 2002 to 2020
$4.2M
Mechanisms of CNS node of Ranvier formation.R01NS069688 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI RASBAND, MATTHEW N · 2010 to 2019
$3.4M
Neuroglial interactions at the node of RanvierR37NS044916 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI RASBAND, MATTHEW N · 2012 to 2018
$2.9M
NICHD NIH HHS U54 HD083092NINDS NIH HHS NS044916NINDS NIH HHS NS069688NINDS NIH HHS R01 NS044916NINDS NIH HHS R01 NS069688NINDS NIH HHS R37 NS044916
6 · The paper itself

Abstract

Myelinated axons are patterned into discrete and often-repeating domains responsible for the efficient and rapid transmission of electrical signals. These domains include nodes of Ranvier and axon initial segments. Disruption of axonal patterning leads to nervous system dysfunction. In this review, we introduce the concept of subcellular patterning as applied to axons and discuss how these patterning events depend on both intrinsic, cytoskeletal mechanisms and extrinsic, myelinating glia-dependent mechanisms.

Indexed as

AnimalsAxonsCytoskeletonHumansMyelin SheathNerve Fibers, MyelinatedNeurogliaNeurons

Identifiers

PMID25710532
PMCPMC4342849

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.