ArticleApplied and environmental microbiology2015
phoU inactivation in Pseudomonas aeruginosa enhances accumulation of ppGpp and polyphosphate.
Article in Applied and environmental microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 58 citations in OpenAlex.
- Deciphering the genetic background of an industrial 2-ketogluconic acid-producing strain Pseudomonas plecoglossicida JUIM01 using whole-genome sequencing.Biotechnology for biofuels and bioproducts · 2026Article
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- Multiple clades of regulators contribute to bacterial phosphate homeostasis and pathogenesis.bioRxiv : the preprint server for biology · 2025Article
- PhoU interaction with the PhoR PAS domain is required for repression of the pho regulon and Salmonella virulence, but not for polyphosphate accumulation.Journal of microbiology (Seoul, Korea) · 2025Article
- Novilysobacter viscosus sp. Nov. and Novilysobacter longmucuonensis sp. Nov., two Nov.l species capable of producing proteases and RiPPs.BMC microbiology · 2025Article
- Loss of LasR function leads to decreased repression ofJournal of bacteriology · 2025Article
- The adjacent ATP-binding protein-encoding genes of theJournal of bacteriology · 2025Article
- Small DUF1127 proteins regulate bacterial phosphate metabolism through protein-protein interactions with the sensor kinase PhoR.microLife · 2025Article
- Adherence and metal-ion acquisition gene expression increases during infection withInfection and immunity · 2024Article
- Ppx1 putative exopolyphosphatase is essential for polyphosphate accumulation inApplied and environmental microbiology · 2024Article
- Hidden diversity and potential ecological function of phosphorus acquisition genes in widespread terrestrial bacteriophages.Nature communications · 2024Article
- Inhibition of Polyphosphate Degradation inJournal of microbiology and biotechnology · 2024Article
- Recent Advances in Bacterial Persistence Mechanisms.International journal of molecular sciences · 2023Review
- Plasmids manipulate bacterial behaviour through translational regulatory crosstalk.PLoS biology · 2023Article
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- The Global Regulator PhoU Positively Controls Growth and Butenyl-Spinosyn Biosynthesis inFrontiers in microbiology · 2022Article
- Inorganic polyphosphate in host and microbe biology.Trends in microbiology · 2021Review
- Dissecting the molecular diversity and commonality of bovine and human treponemes identifies key survival and adhesion mechanisms.PLoS pathogens · 2021Article
- Genome-Wide Mapping Reveals Complex Regulatory Activities of BfmR inMicroorganisms · 2021Article
- Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inorganic polyphosphate (polyP) is a linear polymer composed of several molecules of orthophosphate (Pi) linked by energy-rich phosphoanhydride bonds. In Pseudomonas aeruginosa, Pi is taken up by the ABC transporter Pst, encoded by an operon consisting of five genes. The first four genes encode proteins involved in the transport of Pi and the last gene of the operon, phoU, codes for a protein which exact function is unknown. We show here that the inactivation of phoU in P. aeruginosa enhanced Pi removal from the medium and polyP accumulation. The phoU mutant also accumulated high levels of the alarmone guanosine tetraphosphate (ppGpp), which in turn increased the buildup of polyP. In addition, phoU inactivation had several pleiotropic effects, such as reduced growth rate and yield and increased sensitivity to antibiotics and stresses. However, biofilm formation was not affected by the phoU mutation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.