ArticleEpidemiology (Cambridge, Mass.)2015
Long-term exposure to air pollution and markers of inflammation, coagulation, and endothelial activation: a repeat-measures analysis in the Multi-Ethnic Study of Atherosclerosis (MESA).
Article in Epidemiology (Cambridge, Mass.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 114 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Impact of Particulate Matters Air Pollution on Accelerated Atherosclerosis: A Montelukast Interventional Study for Atherosclerosis Prevention in Modernizing China
Reducing AIR Pollution Exposure to Lower Blood PRESSURE
Who cites it
114 citing papers in PubMed, 5 syntheses or guidelines pooled it, 249 citations in OpenAlex.
- Associations of exposure to PMBMC public health · 2025Pooled it
- Association between ambient air pollution exposure and pregnancy outcomes in women treated with assisted reproductive technology: an updated systematic review and meta-analysis.BMC public health · 2025Pooled it
- Air pollutants and ovarian reserve: a systematic review of the evidence.Frontiers in public health · 2024Pooled it
- Particulate Matter 2.5 and Hematological Disorders From Dust to Diseases: A Systematic Review of Available Evidence.Frontiers in medicine · 2021Pooled it
- The short- and long-term associations of particulate matter with inflammation and blood coagulation markers: A meta-analysis.Environmental pollution (Barking, Essex : 1987) · 2020Pooled it
- Ambient air pollution and neurotoxicity on brain structure: Evidence from women's health initiative memory study.Annals of neurology · 2015Trial
- Long-term ambient air pollution is not associated with circulating soluble urokinase plasminogen activator receptor.Environmental epidemiology (Philadelphia, Pa.) · 2026Article
- PMEnvironment & health (Washington, D.C.) · 2026Article
- Air pollutants, genetic susceptibility, and the risk of age-related macular degeneration: a large prospective cohort study.European journal of epidemiology · 2026Article
- Long-term air pollution exposure and gait speed decline among older Adults: A longitudinal analysis.Environmental research · 2026Article
- Tracking biochemical indicators of air pollution exposure in acute cardiorespiratory emergencies: a scoping review.Frontiers in public health · 2026Article
- CT findings in biomass smoke-associated interstitial lung disease: A retrospective analysis.Journal of clinical imaging science · 2026Article
- Cross-sectional evaluation of exposure to ozone, nitrogen dioxide, and particulate mass levels on circulating immune markers in women in the California Teachers Study.Scientific reports · 2025Article
- Bidirectional effect modification of greenness exposure and air pollution on ischemic stroke mortality across different temporal scales.BMC public health · 2025Article
- Cross-sectional evaluation of exposure to ozone, nitrogen dioxide, and particulate mass levels on circulating immune markers in women in the California Teachers Study.Research square · 2025Article
- Chemokine-complement cascade in glial-vascular units protects neurons from non-biogenic nanoparticles.Journal of neuroinflammation · 2025Article
- Article
- Diesel exhaust particle extract elicits an oxPAPC-like transcriptomic profile in macrophages across multiple mouse strains.Environmental pollution (Barking, Essex : 1987) · 2024Article
- The effects of fine particulate matter, solid fuel use and greenness on the risks of diabetes in middle-aged and older Chinese.Journal of exposure science & environmental epidemiology · 2024Article
- Indoor and ambient black carbon and fine particulate matter associations with blood biomarkers in COPD patients.The Science of the total environment · 2024Article
54 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundAir pollution is associated with cardiovascular disease, and systemic inflammation may mediate this effect. We assessed associations between long- and short-term concentrations of air pollution and markers of inflammation, coagulation, and endothelial activation.
methodsWe studied participants from the Multi-Ethnic Study of Atherosclerosis from 2000 to 2012 with repeat measures of serum C-reactive protein (CRP), interleukin-6 (IL-6), fibrinogen, D-dimer, soluble E-selectin, and soluble Intercellular Adhesion Molecule-1. Annual average concentrations of ambient fine particulate matter (PM2.5), individual-level ambient PM2.5 (integrating indoor concentrations and time-location data), oxides of nitrogen (NOx), nitrogen dioxide (NO2), and black carbon were evaluated. Short-term concentrations of PM2.5 reflected the day of blood draw, day prior, and averages of prior 2-, 3-, 4-, and 5-day periods. Random-effects models were used for long-term exposures and fixed effects for short-term exposures. The sample size was between 9,000 and 10,000 observations for CRP, IL-6, fibrinogen, and D-dimer; approximately 2,100 for E-selectin; and 3,300 for soluble Intercellular Adhesion Molecule-1.
resultsAfter controlling for confounders, 5 µg/m increase in long-term ambient PM2.5 was associated with 6% higher IL-6 (95% confidence interval = 2%, 9%), and 40 parts per billion increase in long-term NOx was associated with 7% (95% confidence interval = 2%, 13%) higher level of D-dimer. PM2.5 measured at day of blood draw was associated with CRP, fibrinogen, and E-selectin. There were no other positive associations between blood markers and short- or long-term air pollution.
conclusionsThese data are consistent with the hypothesis that long-term exposure to air pollution is related to some markers of inflammation and fibrinolysis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.