ReviewBioMed research international2015
Biochemical storage lesions occurring in nonirradiated and irradiated red blood cells: a brief review.
Review in BioMed research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 47 citations in OpenAlex.
- Microfluidic Chip Platforms for Red Blood Cell Storage Lesion Quality Control and Precision Transfusion.Research (Washington, D.C.) · 2026Review
- Irradiated red blood cell transfusion is associated with an increased incidence of deep vein thrombosis in trauma patients: a cohort study.BMC anesthesiology · 2025Article
- Quality and stability studies of red blood cell concentrates from umbilical cord blood compared to their adult counterparts.Blood transfusion = Trasfusione del sangue · 2025Article
- Reversible Cerebral Vasoconstriction Syndrome Following Blood Transfusion in a Patient With Chronic Anemia: A Case Report.Clinical case reports · 2024Article
- Effects of red blood cell transfusion on patients undergoing cardiac surgery in Queensland - a retrospective cohort study.Journal of cardiothoracic surgery · 2024Article
- Nanoparticles for active combination radio mitigating agents of zinc coumarate and zinc caffeinate in a rat model.Environmental science and pollution research international · 2022Article
- Combined Administration of Fibrinogen and Factor XIII Concentrate Does Not Improve Dilutional Coagulopathy Superiorly Than Sole Fibrinogen Therapy: Results of an In-Vitro Thrombelastographic Study.Journal of clinical medicine · 2021Article
- Dose-dependent efficacy of antioxidant nanoparticles on red blood cells storage.Journal of education and health promotion · 2021Article
- The Effect of Pre-Storage Irradiation Blood on Quality of Red Blood Cells.International journal of hematology-oncology and stem cell research · 2021Article
- Donor-dependent aging of young and old red blood cell subpopulations: Metabolic and functional heterogeneity.Transfusion · 2020Article
- Double-filtered leukoreduction as a method for risk reduction of transfusion-associated graft-versus-host disease.PloS one · 2020Article
- Biochemical changes in whole blood stored for transfusion at Bungoma County Referral Hospital, Kenya.African journal of laboratory medicine · 2020Article
- Metabolic effects occurring in irradiated and non-irradiated red blood cellular components for clinical transfusion practice: An in vitro comparison.African journal of laboratory medicine · 2018Article
- Nanostructural Changes in the Cell Membrane of Gamma-Irradiated Red Blood Cells.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2017Article
- Rat red blood cell storage lesions in various additive solutions.Clinical hemorheology and microcirculation · 2017Article
- Transfusion as an Inflammation Hit: Knowns and Unknowns.Frontiers in immunology · 2016Review
- Irradiating stored blood and storing irradiated blood: Is it different? - A study of serial changes in biochemical parameters of red blood cell units.Asian journal of transfusion scienceArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Red blood cells undergo a series of biochemical fluctuations during 35-42-day storage period at 1°C to 6°C. The sodium/potassium pump is immobilised causing a decrease in intracellular potassium with an increase in cytoplasmic sodium levels, glucose levels decline, and acidosis occurs as a result of low pH levels. The frailty of stored erythrocytes triggers the formation of haemoglobin-containing microparticles and the release of cell-free haemoglobin which may add to transfusion difficulties. Lipid peroxidation, oxidative stress to band 3 structures, and other morphological and structural molecular changes also occur leading to spheroechinocytes and osmotic fragility. These changes that transpire in the red cells during the storage period are referred to as "storage lesions." It is well documented that gamma irradiation exacerbates storage lesions and the reports of increased potassium levels leading to adverse reactions observed in neonates and infants have been of particular concern. There are, however, remarkably few systematic studies comparing the in vitro storage lesions of irradiated and nonirradiated red cell concentrates and it has been suggested that the impact of storage lesions on leucocyte reduced red blood cell concentrate (RBCC) is incomplete. The review examines storage lesions in red blood cells and their adverse effects in reference to blood transfusion.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.