Evidence map›Paper›PMID 25710027›Full record

Trial reportBioMed research international2015

Effects of surgical and dietary weight loss therapy for obesity on gut microbiota composition and nutrient absorption.

Antje Damms-Machado, Suparna Mitra, Asja E Schollenberger, Klaus Michael Kramer, Tobias Meile, Alfred Königsrainer, Daniel H Huson, Stephan C Bischoff

3 registry-linked trialsOpen access · hybridAbstract readClinical TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BioMed research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 150 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
150citing papers in PubMed, 6 pooled it
17.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01344525 narecruitingnot on this map

Pilot Project on Interdisciplinary Therapy of Obesity and Its Consequences on Body Weight, Quality of Life and Gastrointestinal Parameters

TypeinterventionalSponsorUniversity of HohenheimRan2009 to 2029Enrolled480ConditionsObesity, Weight LossArmsLaparoscopic gastric sleeve, Gastric Banding, Multidisciplinary lifstyle intervention, Roux-en-Y Bypass
NCT04200521 unknown statusnot on this mapstarted 2019, after this paper: background citation

The Effect of Bariatric Procedures on Gut Microbiota, Gut Peptide and Metabolism in Obese Individuals in United Arab Emirates and Lebanon

Typeobservational_patient_registrySponsorZayed UniversityRan2019 to 2020Enrolled160ConditionsBariatric Surgery, Microbiota, Obesity, Dysbiosis
NCT05459675 naunknown statusnot on this mapstarted 2022, after this paper: background citation

Effects of Very Low-calorie Diet Versus Bariatric Surgery on Body Composition and Gut Microbiota Pattern in Obese Patients

TypeinterventionalSponsorMahidol UniversityRan2022 to 2023Enrolled54ConditionsObesityArmsVery low-calorie diet, Bariatric surgery
3 · Its place in the literature

Who cites it

150 citing papers in PubMed, 6 syntheses or guidelines pooled it, 291 citations in OpenAlex.

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  15. Timing of food intake impacts daily rhythms of human salivary microbiota: a randomized, crossover study.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2018
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90 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Antje Damms-MachadoDepartment of Nutritional Medicine, University of Hohenheim, Fruwirthstraße 12, 70599 Stuttgart, Germany.
Suparna MitraSingapore Centre on Environmental Life Sciences Engineering, Nanyang Technological University, Singapore 637551.ORCID 0000-0002-9378-1496
Asja E SchollenbergerDepartment of Nutritional Medicine, University of Hohenheim, Fruwirthstraße 12, 70599 Stuttgart, Germany ; Department of General, Visceral and Transplant Surgery, University of Tübingen, 72076 Tübingen, Germany.
Klaus Michael KramerDepartment of General and Visceral Surgery, Chirurgische Klinik München-Bogenhausen, 81679 Munich, Germany.
Tobias MeileDepartment of General, Visceral and Transplant Surgery, University of Tübingen, 72076 Tübingen, Germany.
Alfred KönigsrainerDepartment of General, Visceral and Transplant Surgery, University of Tübingen, 72076 Tübingen, Germany.
Daniel H HusonSingapore Centre on Environmental Life Sciences Engineering, Nanyang Technological University, Singapore 637551 ; Center for Bioinformatics, University of Tübingen, 72076 Tübingen, Germany.
Stephan C BischoffDepartment of Nutritional Medicine, University of Hohenheim, Fruwirthstraße 12, 70599 Stuttgart, Germany.
University of Hohenheim · DENanyang Technological University · SGUniversity of Tübingen · DEMünchen Klinik Bogenhausen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Evidence suggests a correlation between the gut microbiota composition and weight loss caused by caloric restriction. Laparoscopic sleeve gastrectomy (LSG), a surgical intervention for obesity, is classified as predominantly restrictive procedure. In this study we investigated functional weight loss mechanisms with regard to gut microbial changes and energy harvest induced by LSG and a very low calorie diet in ten obese subjects (n = 5 per group) demonstrating identical weight loss during a follow-up period of six months. For gut microbiome analysis next generation sequencing was performed and faeces were analyzed for targeted metabolomics. The energy-reabsorbing potential of the gut microbiota decreased following LSG, indicated by the Bacteroidetes/Firmicutes ratio, but increased during diet. Changes in butyrate-producing bacterial species were responsible for the Firmicutes changes in both groups. No alteration of faecal butyrate was observed, but the microbial capacity for butyrate fermentation decreased following LSG and increased following dietetic intervention. LSG resulted in enhanced faecal excretion of nonesterified fatty acids and bile acids. LSG, but not dietetic restriction, improved the obesity-associated gut microbiota composition towards a lean microbiome phenotype. Moreover, LSG increased malabsorption due to loss in energy-rich faecal substrates and impairment of bile acid circulation. This trial is registered with ClinicalTrials.gov NCT01344525.

Indexed as

Caloric RestrictionGastrectomyIntestinal AbsorptionBacteriaCombined Modality TherapyFemaleGastrointestinal MicrobiomeGermanyHumansMiddle AgedObesityTreatment Outcome

Identifiers

PMID25710027
PMCPMC4330959
OpenAlexW2048380404

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.