ArticleTropical parasitology
Management of granulomatous amebic encephalitis: Laboratory diagnosis and treatment.
Article in Tropical parasitology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 51 citations in OpenAlex.
- Granulomatous amoebic encephalitis: pathogenesis, diagnostic advances, therapeutic challenges, and emerging treatment strategies.Medical microbiology and immunology · 2026Review
- Leveraging microphysiological systems to expedite understanding of host-parasite interactions.PLoS pathogens · 2025Review
- Fatal amoebic meningoencephalitis caused byFrontiers in veterinary science · 2025Article
- Protists and protistology in the Anthropocene: challenges for a climate and ecological crisis.BMC biology · 2024Review
- Review
- First report on the long-term viability ofJournal of water and health · 2024Article
- Modelling amoebic brain infection caused by Balamuthia mandrillaris using a human cerebral organoid.PLoS neglected tropical diseases · 2024Article
- Azole-based compounds as potential anti-RSC medicinal chemistry · 2024Article
- Occurrence of Free-Living Amoebae in Non-Human Primate Gut.Tropical medicine and infectious disease · 2024Article
- Amoebicidal effect of synthetic indoles againstAntimicrobial agents and chemotherapy · 2024Article
- Self-assembled micelles loaded with itraconazole as anti-Acanthamoeba nano-formulation.Archives of microbiology · 2024Article
- Non-granulomatous meningoencephalitis withSurgical neurology international · 2024Article
- Biological characteristics and pathogenicity ofFrontiers in microbiology · 2023Review
- Genotyping and Molecular Identification of Acanthamoeba Genotype T4 and Naegleria fowleri from Cerebrospinal Fluid Samples of Patients in Turkey: Is it the Pathogens of Unknown Causes of Death?Acta parasitologica · 2022Article
- Granulomatous Diseases of the Central Nervous System.Current neurology and neuroscience reports · 2022Review
- Various brain-eating amoebae: the protozoa, the pathogenesis, and the disease.Frontiers of medicine · 2021Review
- Article
- Immunopathogenicity ofInternational journal of molecular sciences · 2021Review
- A rare case ofMedical mycology case reports · 2020Article
- Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Granulomatous amebic encephalitis is a life-threatening central nervous system (CNS) infection caused by the free-living amoebae Acanthamoeba spp., Balamuthia mandrillaris and Sappinia pedata. The disease has a subacute to chronic onset affecting commonly the immunocompromised population with high mortality rate. The diagnosis of this disease entity requires high suspicion with appropriate sample collection and testing by the laboratory experts. Radiological investigations are nonspecific and commonly confused with CNS tuberculosis, neurocysticercosis, disseminated encephalomyelitis, viral encephalitis etc., delaying the accurate diagnosis of these cases. Early diagnosis plays a crucial role in the survival of these cases since appropriate management can be initiated. No single drug is effective; hence multiple antibiotics targeting various proteins or receptors are required for successful treatment. A combination of surgical and medical interventions involving multiple specialty experts is required to prevent death and morbidity in survivors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.