Evidence map›Paper›PMID 25709809›Full record

ArticleBiomaterials science2015

The effect of photoinitiators on intracellular AKT signaling pathway in tissue engineering application.

Leyuan Xu, Natasha Sheybani, W Andrew Yeudall, Hu Yang

Open access · greenAbstract read
In one paragraph

Article in Biomaterials science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 58 citations in OpenAlex.

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  14. TiOFrontiers in chemistry · 2018
    Article
  15. Article
  16. Injectable scaffolds: Preparation and application in dental and craniofacial regeneration.Materials science & engineering. R, Reports : a review journal · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Leyuan XuDepartment of Biomedical Engineering, Virginia Commonwealth University, Richmond, Virginia 23284.
Natasha SheybaniDepartment of Biomedical Engineering, Virginia Commonwealth University, Richmond, Virginia 23284.
W Andrew YeudallPhilips Institute of Oral and Craniofacial Molecular Biology, Virginia Commonwealth University, Richmond, Virginia 23298 ; Massey Cancer Center; Virginia Commonwealth University, Richmond, Virginia 23298.
Hu YangDepartment of Biomedical Engineering, Virginia Commonwealth University, Richmond, Virginia 23284 ; Massey Cancer Center; Virginia Commonwealth University, Richmond, Virginia 23298.
University of Richmond · US

Funding

Hybrid Nanoparticles for GlaucomaR01EY024072 · NEI · VIRGINIA COMMONWEALTH UNIVERSITY · PI KOMPELLA, UDAY B, YANG, HU · 2014 to 2016
$1.3M
NEI NIH HHS R01 EY024072NEI NIH HHS R01EY024072
6 · The paper itself

Abstract

Free-radical photopolymerization initiated by photoinitiators is an important method to make tissue engineering scaffolds. To advance understanding of photoinitiator cytocompatibility, we examined three photoinitiators including 2,2-dimethoxy-2-phenylacetophenone (DMPA), Irgacure 2959 (I-2959), and eosin Y photoinitiating system (EY) in terms of their effects on viability of HN4 cells and expression levels of intracellular AKT and its phosphorylated form p-AKT. Our results show that the photoinitiators and their UV-exposed counterparts affect intracellular AKT signaling, which can be used in conjunction with cell viability for cytocompatibility assessment of photoinitiators.

Indexed as

AcetophenonesCell SurvivalPhotochemistryPolymerizationProto-Oncogene Proteins c-aktSignal TransductionTissue EngineeringTissue ScaffoldsUltraviolet Rays2,2-dimethoxy-2-phenylacetophenoneAcetophenonesProto-Oncogene Proteins c-akt

Identifiers

PMID25709809
PMCPMC4335638
OpenAlexW2073354219

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.