Evidence map›Paper›PMID 25709800›Full record

ArticleInternational journal of preventive medicine2014

Pomegranate Flower Extract does not Prevent Cisplatin-Induced Nephrotoxicity in Female Rats.

Sima Jilanchi, Mehdi Nematbakhsh, Safoora Mazaheri, Ardeshir Talebi, Behzad Zolfaghari, Zahra Pezeshki, Fatemeh Eshraghi-Jazi, Maryam Moeini

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in International journal of preventive medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Review
  3. Cisplatin chemotherapy and renal function.Advances in cancer research · 2021
    Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Sima JilanchiWater and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Mehdi NematbakhshWater and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran ; Department of Physiology, Isfahan MN Institute of Basic and Applied Sciences Research, Isfahan, Iran ; Isfahan MN Institute of Basic and Applied Sciences Research, Isfahan, Iran.
Safoora MazaheriWater and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Ardeshir TalebiWater and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran ; Department of Clinical Pathology, Isfahan University of Medical Sciences, Isfahan, Iran.
Behzad ZolfaghariWater and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran ; Department of Pharmacognosy, Isfahan University of Medical Sciences, Isfahan, Iran.
Zahra PezeshkiWater and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Fatemeh Eshraghi-JaziWater and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Maryam MoeiniWater and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Isfahan University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNephrotoxicity is the major side-effect of cisplatin (CDDP), and it is reported to be gender-related. We evaluated the effects of pomegranate flower extract (PFE) as an antioxidant on CDDP-induced nephrotoxicity in female rats.

methodsTwenty-three adult female rats in four groups treated as following. Groups 1 and 2 received PFE at doses of 25 and 50 (mg/kg/day), respectively, for 9 days, and from day 3 on, they also received cisplatin (CDDP) (2.5 mg/kg) daily. Group 3 was treated as group 1 expects saline instead of PFE, and group 4 received PFE (25 mg/kg/day) alone.

resultsCisplatin alone increased the serum levels of blood urea nitrogen, creatinine, and nitrite; and kidney tissue damage score and kidney weight. However, PFE not only did not ameliorate the induced nephrotoxicity, but also aggravated renal tissue damage.

conclusionsPomegranate extract as an antioxidant did not ameliorate CDDP-induced nephrotoxicity in female rats.

Indexed as

Cisplatinfemale ratsnephrotoxicitypomegranate

Identifiers

PMID25709800
PMCPMC4336995
OpenAlexW2114054808

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.