Evidence map›Paper›PMID 25709639›Full record

ArticleIranian journal of reproductive medicine2014

Combination effect of Pentoxifylline and L-carnitine on idiopathic oligoasthenoteratozoospermia.

Najme Moslemi Mehni, Ali Asghar Ketabchi, Ebrahim Hosseini

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in Iranian journal of reproductive medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 7 pooled it
0.8field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 7 syntheses or guidelines pooled it, 34 citations in OpenAlex.

  1. Pooled it
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  3. Antioxidants for male subfertility.The Cochrane database of systematic reviews · 2022
    Pooled it
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  7. Antioxidants for male subfertility.The Cochrane database of systematic reviews · 2019
    Pooled it
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  20. Role of Antioxidants in Assisted Reproductive Techniques.The world journal of men's health · 2017
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Najme Moslemi MehniIslamic Azad University, Science and Research Branch, Fars Province, Shiraz, Iran.
Ali Asghar KetabchiPhysiology Research Center, Kerman University of Medical Sciences, Kerman, Iran.
Ebrahim HosseiniIslamic Azad University, Science and Research Branch, Fars Province, Shiraz, Iran.
Kerman University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPentoxifylline (PX) is a methyl xanthine derivative that influences the sperm motion characteristics and L-carnitine (L-C) is an amino acid that is naturally produced in the body. In general, separate administration of PX and L-C has been reported to be effective on preserving sperm motility in vitro, and also when is consumed orally by the Idiopathic oligoasthenoteratozoospermia (IOAT) patients.

objectiveThe aim of this study was to evaluate any possible effect of a combination of L-C and PX on sperm characteristics and improving the type of assisted reproductive techniques (ART) in a group of patients with unexplained oligoasthenoteratozoospermia. MATERIALS AND

methodsTwo hundred twelve infertile men with IOAT in a double-blind, placebo-controlled, randomized clinical trial were allocated for this study. They randomized to four groups. Group I received PX/ and L-C (each one, twice daily), group II, PX and placebo, group III, L-C with the placebo, and group IV, received placebo tablets. Finally, we compared pre and post intervention sperm parameters and ART procedures between groups.

resultsWhile the use of PX and L-C are only improved sperm motility, but their combined uses improved all sperm parameters, especially the sperm count. Also the combination of PX and L-C was effective on improving the ART procedures (p<0.01).

conclusionOur results demonstrate that the combination use of PX and L-C is useful in improving of sperm parameters in IOAT patients and also, improve ART procedures in this group of patients.

Indexed as

IdiopathicL-carnitineMale infertilityOligoasthenoteratozoospermiaPentoxifylline

Identifiers

PMID25709639
PMCPMC4330662
OpenAlexW2307096582

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.