ArticleIranian journal of reproductive medicine2014
Immunohistochemical detection of the 1,25-dihydroxy vitamin D receptor in the human vagina.
Article in Iranian journal of reproductive medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.
- Vitamin D and VDR in Gynecological Cancers-A Systematic Review.International journal of molecular sciences · 2017Pooled it
- Vaginal vitamin D for Genitourinary syndrome of menopause: a cohort study and literature review.Future science OA · 2026Article
- Non-linear association between serum vitamin D and bacterial vaginosis in U.S. women: analysis from NHANES 2001-2004.Frontiers in nutrition · 2025Article
- Effect of Vitamin D on the Proliferation and Barrier of Atrophic Vaginal Epithelial Cells.Molecules (Basel, Switzerland) · 2023Article
- Vitamin D Status Impacts Genital Mucosal Immunity and Markers of HIV-1 Susceptibility in Women.Nutrients · 2020Article
- Effect of Vitamin D on the Vaginal Health of Menopausal Women: A Systematic Review.Journal of menopausal medicine · 2019Review
- Vitamin D Proliferates Vaginal Epithelium through RhoA Expression in Postmenopausal Atrophic Vagina tissue.Molecules and cells · 2017Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundVitamin D plays a critical role in the regulation of growth and differentiation of squamous epithelium. The pleiotropic effects of 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], include proliferative, pro-apoptotic, and pro-differentiation effects on numerous cell types. Although 1,25-dihydroxyvitamin D3 is involved in the regulation and differentiation of epithelium, there is no data in the aspect of the distribution of 1,25-(OH)2D3 receptor (VDR), estrogen receptor-β (ER-β) and ezrin, and how it changes according to the menstrual phases and serum vitamin D level in the human vagina.
objectiveTo detect of the 1,25-dihydroxyvitamin D3 receptor (VDR), estrogen receptor-β (ER-β), and ezrin in human vagina. MATERIALS AND
methodsThis cross-sectional study enrolled 15 premenopausal women who had hysterectomies. Vaginal tissues were obtained from vaginal vaults of hysterectomized uterus and processed for immunohistochemical analysis. We recorded the localization, distribution, and expression of VDR, ER-β, and ezrin in the vaginal epithelium.
resultsVDR was detected in all layers of vaginal epithelium regardless of the menstrual cycle stage and serum 25-hydroxyvitamin D levels.
conclusionIn this study, we have characterized the presence and distribution of VDR, ER-β, and ezrin in human vaginal epithelium, including menstrual cycle-related and vitamin D-related expression. However, the VDR-related mechanisms underlying vaginal epithelial proliferation and differentiation remain to be elucidated.
Indexed as
Identifiers
25709637PMC4330660W2261581307What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.