Evidence map›Paper›PMID 25709496›Full record

ArticleJournal of pain research2015

Reanalysis of morphine consumption from two randomized controlled trials of gabapentin using longitudinal statistical methods.

Shiyuan Zhang, James Paul, Manyat Nantha-Aree, Norman Buckley, Uswa Shahzad, Ji Cheng, Justin DeBeer, Mitchell Winemaker, David Wismer, Dinshaw Punthakee and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of pain research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Trial
  2. Regional and Multimodal Analgesia to Reduce Opioid Use After Total Joint Arthroplasty: A Narrative Review.HSS journal : the musculoskeletal journal of Hospital for Special Surgery · 2019
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Shiyuan ZhangDepartment of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada.
James PaulDepartment of Anesthesia, McMaster University, Hamilton, ON, Canada.
Manyat Nantha-AreeDepartment of Anesthesia, McMaster University, Hamilton, ON, Canada.
Norman BuckleyDepartment of Anesthesia, McMaster University, Hamilton, ON, Canada.
Uswa ShahzadDepartment of Anesthesia, McMaster University, Hamilton, ON, Canada.
Ji ChengDepartment of Anesthesia, McMaster University, Hamilton, ON, Canada.
Justin DeBeerDepartment of Surgery, Division of Orthopaedics, McMaster University, Hamilton, ON, Canada.
Mitchell WinemakerDepartment of Surgery, Division of Orthopaedics, McMaster University, Hamilton, ON, Canada.
David WismerDepartment of Surgery, Division of Orthopaedics, McMaster University, Hamilton, ON, Canada.
Dinshaw PunthakeeDepartment of Surgery, Division of Orthopaedics, McMaster University, Hamilton, ON, Canada.
Victoria AvramDepartment of Surgery, Division of Orthopaedics, McMaster University, Hamilton, ON, Canada.
Lehana ThabaneDepartment of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada ; Department of Anesthesia, McMaster University, Hamilton, ON, Canada ; Biostatistics Unit/Centre for Evaluation of Medicines, St Joseph's Healthcare-Hamilton, Hamilton, ON, Canada ; Population Health Research Institute, Hamilton Health Science/McMaster University, Hamilton, ON, Canada.
McMaster University · CAPopulation Health Research Institute · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPostoperative pain management in total joint replacement surgery remains ineffective in up to 50% of patients and has an overwhelming impact in terms of patient well-being and health care burden. We present here an empirical analysis of two randomized controlled trials assessing whether addition of gabapentin to a multimodal perioperative analgesia regimen can reduce morphine consumption or improve analgesia for patients following total joint arthroplasty (the MOBILE trials).

methodsMorphine consumption, measured for four time periods in patients undergoing total hip or total knee arthroplasty, was analyzed using a linear mixed-effects model to provide a longitudinal estimate of the treatment effect. Repeated-measures analysis of variance and generalized estimating equations were used in a sensitivity analysis to compare the robustness of the methods.

resultsThere was no statistically significant difference in morphine consumption between the treatment group and a control group (mean effect size estimate 1.0, 95% confidence interval -4.7, 6.7, P=0.73). The results remained robust across different longitudinal methods.

conclusionThe results of the current reanalysis of morphine consumption align with those of the MOBILE trials. Gabapentin did not significantly reduce morphine consumption in patients undergoing major replacement surgeries. The results remain consistent across longitudinal methods. More work in the area of postoperative pain is required to provide adequate management for this patient population.

Indexed as

gabapentinpostoperative morphine consumptionrandomized controlled trialsreanalysis

Identifiers

PMID25709496
PMCPMC4332293
OpenAlexW2148451595

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.