ArticlePharmacognosy magazine
Gastroprotective effect of alpha-pinene and its correlation with antiulcerogenic activity of essential oils obtained from Hyptis species.
Article in Pharmacognosy magazine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 70 citations in OpenAlex.
- Himalayan medicinal plants for gastrointestinal disorders: ethnopharmacology and mechanistic insights.Inflammopharmacology · 2026Review
- Subacute Oral Toxicity Evaluation of Red Pine Oil in Sprague-Dawley Rats: Safety Profiling for Potential Therapeutic Use.Journal of toxicology · 2026Article
- Article
- Antiviral and cytotoxic activities and chemical profiles of two species ofTurkish journal of chemistry · 2024Article
- Efficacy and safety of alpha-pinene capsule in the management of functional dyspepsia and eradication of helicobacter pylori: a randomized clinical trial.Gastroenterology and hepatology from bed to bench · 2024Article
- The effects of alpha-pinene on the Nrf2-HO1 signaling pathway in gastric damage in rats.Molecular biology reports · 2023Article
- Review
- Volatile Compounds in Norway Spruce (Plants (Basel, Switzerland) · 2023Article
- The Essential Oil ofPlants (Basel, Switzerland) · 2022Article
- The pinene scaffold: its occurrence, chemistry, synthetic utility, and pharmacological importance.RSC advances · 2022Review
- Gastroprotective Effect of MicroencapsulatedMolecules (Basel, Switzerland) · 2022Article
- Ultra-Performance Liquid Chromatography-Mass Spectrometry-Based Untargeted Metabolomics Reveals the Key Potential Biomarkers for Castor Meal-Induced Enteritis in Juvenile Hybrid Grouper (Frontiers in nutrition · 2022Article
- FeClMaterials (Basel, Switzerland) · 2021Article
- Essential Oils of NewMolecules (Basel, Switzerland) · 2021Article
- Subtribe Hyptidinae (Lamiaceae): A promising source of bioactive metabolites.Journal of ethnopharmacology · 2021Review
- A Review of the Potential Use of Pinene and Linalool as Terpene-Based Medicines for Brain Health: Discovering Novel Therapeutics in the Flavours and Fragrances of Cannabis.Frontiers in psychiatry · 2021Review
- (-)-Carveol Prevents Gastric Ulcers via Cytoprotective, Antioxidant, Antisecretory and Immunoregulatory Mechanisms in Animal Models.Frontiers in pharmacology · 2021Article
- Recent studies on pinene and its biological and pharmacological activities.EXCLI journal · 2021Article
- The essential oil of Hyptis crenata Pohl ex Benth. presents an antiedematogenic effect in mice.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2021Article
- Identification of Polyphenols from Coniferous Shoots as Natural Antioxidants and Antimicrobial Compounds.Molecules (Basel, Switzerland) · 2020Article
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlpha-pinene (α-pinene) is a monoterpene commonly found in essential oils with gastroprotective activity obtained from diverse medicinal plants, including Hyptis species. The genus Hyptis (lamiaceae) consists of almost 400 species widespread in tropical and temperate regions of America. In the north and northeastern Brazil, some Hyptis species are used in traditional medicine to treat gastrointestinal disturbances.
objectiveThe present study has investigated the gastoprotective effect of purified α-pinene in experimental gastric ulcer induced by ethanol and indomethacin in mice. MATERIALS AND
methodsGastric ulcers were induced in male Swiss mice (20-30 g) by oral administration of absolute ethanol or indomethacin 45 min after oral pretreatment with vehicle, standard control drugs or α-pinene (10, 30, and 100 mg/kg). One hour after the ulcerative challenges, the stomach were removed, and gastric lesions areas measured. The effects of α-pinene on the gastric juice acidity were determined by pylorus ligation model. The gastrointestinal motility and mucus depletion were determined by measuring the gastric levels of phenol red and alcian blue, respectively. Hematoxylin and eosin stained sections of gastric mucosa of the experimental groups were used for histology analysis.
resultsα-pinene pretreatment inhibited ethanol-induced gastric lesions, reduced volume and acidity of the gastric juice and increased gastric wall mucus (P < 0.05). Furthermore, we showed an interesting correlation between concentration of α-pinene and gastroprotective effect of Hyptis species (P Pearson = 0.98).
conclusionOur data showed that the α-pinene exhibited significant antiulcerogenic activity and a great correlation between concentration of α-pinene and gastroprotective effect of Hyptis species was also observed.
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