Evidence map›Paper›PMID 25709132›Full record

ArticleGhana medical journal2014

Comparing performance of amoxicillin and intramuscular benzathine penicillin in relieving manifestations of streptococcal pharyngitis in children.

S T Eslami, A Nassirian, H Nassirian, E Hatami, E Sobhani, R Najibpour

Open access · hybridAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Ghana medical journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 3 pooled it
1.0field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 3 syntheses or guidelines pooled it, 10 citations in OpenAlex.

  1. Guideline
  2. Different antibiotic treatments for group A streptococcal pharyngitis.The Cochrane database of systematic reviews · 2023
    Pooled it
  3. Different antibiotic treatments for group A streptococcal pharyngitis.The Cochrane database of systematic reviews · 2021
    Pooled it
  4. Article
  5. Review
  6. Different antibiotic treatments for group A streptococcal pharyngitis.The Cochrane database of systematic reviews · 2016
    Review
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

S T EslamiDepartment of Pediatrics, Islamic Azad University, Tehran Medical Sciences Branch, Tehran, Iran.
A NassirianDepartment of Library, Mashhad Branch, Islamic Azad University, Mashhad, Iran.
H NassirianDepartment of Pediatrics, Islamic Azad University, Tehran Medical Sciences Branch, Tehran, Iran.
E HatamiDepartment of Pathology, Faculty of Medical Sciences, Mashhad University of Medical Sciences, Mashhad, Iran.
E SobhaniDepartment of Library, Mashhad Branch, Islamic Azad University, Mashhad, Iran.
R NajibpourStudents' Research Committee, Tehran Medical Branch, Islamic Azad University, Tehran, Iran.
Islamic Azad University Medical Branch of Tehran · IRIslamic Azad University, Mashhad · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo compare clinical and bacteriologic responses to intramuscular benzathine penicillin G (BPG) and single dose of amoxicillin in Group A streptococcal (GAS) pharyngitis.

designThis study included 571 children from 6 to 15 years old age, with pharyngitis, who were admitted to 45 elementary and guidance schools from 7 regions of Education Organization in North-East of Iran, Mashhad. They were screened for enrollment and if he/she presented pharyngitis with clinical criteria of sore throat, erythema, exudate and tender or enlarged anterior cervical lymph nodes. Exclusion criteria included reports of antibiotic use, negative throat culture for GAS and history of allergy to the drugs. Clinical and bacteriologic responses to BPG and once daily orally amoxicillin were considered and compared.

resultsIn the amoxicillin group, treatment failure was more than the penicillin group (18.9% vs. 6.4%, respectively) but the difference was not statistically significant (p < 0.05). Both drugs were significantly effective in reducing pharyngitis manifestations but penicillin was significantly more effective in reducing exudate than amoxicillin.

conclusionOur study was in line with studies comparing the two drugs. The results show that once-daily therapy with amoxicillin is as effective as intramuscular benzathine penicillin G for the treatment of GAS pharyngitis, but penicillin was significantly more effective in reducing exudate and concurrent signs vs. amoxicillin.

Indexed as

Administration, OralAmoxicillinAnti-Bacterial AgentsChildCoughFemaleHumansInjections, IntramuscularLymphatic DiseasesMalePenicillin G BenzathinePharyngitisStreptococcal InfectionsAmoxicillinAnti-Bacterial AgentsPenicillin G BenzathineAmoxicillinErythemaLymph nodesPenicillinStreptococcal Pharyngitis

Identifiers

PMID25709132
PMCPMC4335436
OpenAlexW2002557965

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.